Clinical study of emergency peripartum hysterectomy for postpartum hemorrhage

Background: The objective of this study was to study indications and the outcome of emergency peripartum hysterectomy for PPH in a tertiary care centre and to study the maternal mortality and morbidity in these patients.Methods: This is an observational study conducted at Vanivilas hospital attached to Bangalore Medical College and Research Institute between January 2014 to December 2015 for 24 months. The women who fulfill the inclusion criteria are studied with respect to parity, gestational age at delivery, route of delivery (vaginal/cesarean), details of instrumental delivery, conservative methods used to control bleeding, ICU admissions and blood transfusions. An analysis of maternal mortality and morbidity was done with respect to development of hypovolemic shock, DIC, anemia, acute kidney injury, septicemia and maternal deaths.Results: The rate of peripartum hysterectomy is 10.1 per 1000 live births. Placental abnormalities (placenta previa and placenta accreta) are the leading indications (41.4%) for peripartum hysterectomy followed by uterine atony (34.5%). All 29 women received blood and blood product transfusions. 34.5% developed febrile morbidity, 27.6% developed DIC, 10.3% developed acute kidney injury and septicemia and 10.3% maternal deaths.Conclusions: PPH is unpredictable in onset, duration and etiology and it remains a major life threatening complication of any delivery. The most common causes of hemorrhage in these women are placental abnormalities and uterine atony. When conservative treatment is not feasible or has failed, prompt peripartum hysterectomy is performed failing which the delay would contribute to the maternal morbidity and mortality

Clinical study of maternal complications associated with eclampsia

Background: Eclampsia is still one of the leading causes of maternal mortality and morbidity in developing countries. Though the incidence in developed nations has drastically reduced, it has remained the same over years in India, mainly due to lack of awareness, poor socio-economic status and inadequate ante natal check-ups. The objective of this study was to determine the presentation, demographic features, risk factors, management, maternal mortality and morbidity, in women presenting with eclampsia.Methods: This study was conducted in Vanivilas hospital from January to December 2014 for 12 months. Total 230 women with eclampsia were studied with respect to their age, parity, socio economic status, gestational age, details of previous antenatal check-ups, clinical features at presentation, nature and number of convulsions, treatment received before admission, management in the institution and maternal morbidity and mortality.Results: The incidence of Eclampsia was 1.4%. 30% were below 20 years of age, 45% were primigravidas, 97% were referred cases with inadequate antenatal checkups. 68% had antepartum eclampsia, 22% had intrapartum eclampsia and 10% had postpartum eclampsia. 24% had instrumental delivery, 24% underwent caesarean delivery. There were 17.4% ICU admissions, 5.7% acute kidney injury cases and 13 maternal deaths.Conclusions: Eclampsia still remains a major cause of maternal morbidity and mortality in india. Information about danger signs of pre-eclampsia/ eclampsia should be made available to antenatal clients. Importance of timely referral to the tertiary center should be emphasised to the peripheral health workers

(2E)-3-(4-Chloro­phen­yl)-1-(4-hy­droxy­phen­yl)prop-2-en-1-one

In the title compound, C15H11ClO2, the dihedral angle between the mean planes of the chloro­benzene and hy­droxy­benzene rings is 6.5 (6)°. The mean plane of the prop-2-en-1-one group makes an angle of 18.0 (1)° with the hy­droxy­phenyl ring and 11.5 (1)° with the chloro­phenyl ring. The crystal packing is stabilized by inter­molecular O—H⋯O hydrogen bonds, weak C—H⋯O, C—H⋯π and π–π stacking inter­actions [centroid–centroid distances = 3.7771 (7) and 3.6917 (7) Å]

1-[5-(4-Chloro­phen­yl)-3-(4-hy­droxy­phen­yl)-4,5-dihydro-1H-pyrazol-1-yl]­ethanone

In the title compound, C17H15ClN2O2, the benzene rings form dihedral angles of 89.56 (5) and 5.87 (5)° with the mean plane of the pyrazoline ring (r.m.s. deviation = 0.084 Å). The dihedral angle between the two benzene rings is 87.57 (5)°. In the crystal, mol­ecules are linked by O—H⋯O and C—H⋯O hydrogen bonds into a helical chain along the c axis. Between the chains weak C—H⋯N and C—H⋯O inter­actions are present. The crystal studied was an inversion twin with a domain ratio of 0.72 (4):0.28 (4)

Early Detection of Parkinson Disease using Voice Data

Parkinson’s disease affects over 10 million people worldwide, with approximately 20 percent of patients not being diagnosed. Clinical diagnosis is expensive because there are no specific tests or bio-markers, and it can take days to diagnose because it is based on a comprehensive evaluation of the individual’s symptoms. Existing research either predicts a Unified Parkinson Disease Rating Scale rating, uses other key Parkinsonian features to diagnose an individual, such as tapping, gait, and tremor, or focuses on different audio features. In this paper, we are focusing on using the voice aspect for the early detection of the disease. We use the University of California Irvine (UCI) Parkinson data set. This data set contains various parameters regarding voice jitter. The data set first undergoes preprocessing. We have used a Feedforward Neural Network (FNN) model to acquire early on detection using the above data set. Our model has achieved an efficiency of 97.43 percent. This efficiency can be improved by using even a larger and diverse data set

Ethyl ({5-[5′-(2-eth­oxy-2-oxoeth­oxy)-4,4′′-difluoro-1,1′:3′,1′′-terphenyl-4′-yl]-1,3,4-oxadiazol-2-yl}sulfan­yl)acetate

In the title compound, C28H24F2N2O6S, the whole mol­ecule is disordered over two sites with refined occupancies of 0.778 (3) and 0.222 (3). The central benzene ring makes dihedral angles of 56.0 (4), 34.5 (4) and 70.9 (4)°, respectively, with the two terminal benzene rings and the 1,3,4-oxadiazole ring in the major component of the disordered mol­ecule. The corresponding angles in the minor component are 59.7 (16), 25.6 (13) and 75.5 (14)°. In the crystal, mol­ecules are linked via C—H⋯F, C—H⋯N, C—H⋯O and C—H⋯S hydrogen bonds into a three-dimensional network. In addition, C—H⋯π inter­actions are observed

1-(4,4′′-Difluoro-5′-meth­oxy-1,1′:3′,1′′-terphenyl-4′-yl)ethanone

In the title compound, C21H16F2O2, the central benzene ring is inclined at dihedral angles of 30.91 (8) and 46.88 (7)° to the two terminal fluoro-substituted rings. The dihedral angle between the two terminal fluoro-subsituted rings is 68.34 (8)°. An intra­molecular C—H⋯O hydrogen bond generates an S(6) ring motif. The crystal structure is stabilized by weak C—H⋯π inter­actions

(E)-1-(4,4′′-Difluoro-5′-meth­oxy-1,1′:3′,1′′-terphenyl-4′-yl)-3-(6-meth­oxy­naphthalen-2-yl)prop-2-en-1-one

In the title compound, C33H24F2O3, the central benzene ring makes dihedral angles of 44.71 (10), 47.80 (10) and 63.68 (9)° with the two fluoro-substituted benzene rings and the naphthalene ring system, respectively. In the crystal, mol­ecules are connected via inter­molecular C—H⋯F and C—H⋯O hydrogen bonds. Furthermore, the crystal structure is stabilized by weak C—H⋯π and π–π inter­actions [centroid–centroid distance = 3.6816 (13) Å]