60 research outputs found
Some Directions of using the Forensic Odorology in the Field of the Fixing Evidences in the Pre-Trial Proceedings in Ukraine
All over the world, the issue of detecting crimes committed is the main task of the state and its law enforcement agencies. The detection of crimes and the prosecution of those who committed them are in most cases based on evidence gathered by law enforcement officers. The issue of evidence is also quite debatable, because the legislation of different countries perceives different aspects of evidence and the evidence itself. The article covers the issue of individual issues related to obtaining evidence with the help of specially trained dogs. These forms and methods were used by Ukrainian law enforcement officials during their stay in the international peacekeeping mission in Kosovo. Currently, some evidence-gathering issues can be used in the process of investigating and prosecuting criminals with trained dogs. However, this area is not widely used, as there are a number of both practical and regulatory, as well as legislative problems. This direction in the activities of the police and other law enforcement agencies is called forensic odorology. The issue of using dogs in the process of detecting and investigating crimes is quite controversial and they are used differently in different countries
STATUS OF THE INVERSE FREE ELECTRON LASER EXPERIMENT AT THE NEPTUNE LABORATORY
Abstract We report on the status of the Inverse Free Electron Laser accelerator experiment under construction at the UCLA Neptune Laboratory. This experiment will use a 400 GW CO 2 laser to accelerate through a tapered undulator an electron beam from 14.5 MeV up to 55 MeV. The scheme proposed is the diffraction dominated IFEL interaction where the Rayleigh range of the laser beam is 3.5 cm, much shorter than the interaction length (the undulator length is 50 cm). The undulator is strongly tapered in both field and period. The present status of the experiment is reported
Status of the Inverse Free Electron Laser Experiment at the Neptune Laboratory
Abstract We report on the status of the Inverse Free Electron Laser accelerator experiment under construction at the UCLA Neptune Laboratory. This experiment will use a 400 GW CO 2 laser to accelerate through a tapered undulator an electron beam from 14.5 MeV up to 55 MeV. The scheme proposed is the diffraction dominated IFEL interaction where the Rayleigh range of the laser beam is 3.5 cm, much shorter than the interaction length (the undulator length is 50 cm). The undulator is strongly tapered in both field and period. The present status of the experiment is reported
ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠΎΠΉ Π² ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΈΡΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
Molecular-genetic study of uveal melanoma (UM) is crucial in predicting the risk of metastasis of this tumor. Such analysis is also possible during organ-sparing treatment based on fine-needle aspiration biopsy (FNAB), however, not all patients may consider this study appropriate and/or accessible.The goal of this study was to analyze the needs of patients with UM for individual metastasis risk prognosis.This retrospective cohort study was conducted using a questionnaire in 94 patients with UM (mean age 60 Β± 13 years; 69 % women and 31 % men). Despite the rather high proportion of interested patients (77 %), only half (51 %) of them ultimately agreed to undergo a βprognosticβ FNAB, which was primarily due to the high cost of this study (it was the main reason for refusal in 76 % of cases). Patients were mainly motivated to know their risk by: a sense of control of the situation and the possibility of taking preventive measures (78 %), future planning for themselves and/or their loved ones (47 %), the possibility of participating in metastatic UM treatment programs (35 %), receiving the maximum amount of information about the disease (28 %). Patients without such intention cited a fear of revealing a high risk of metastases and an impossibility of psychological stabilization based on results of this test.Predicting the risk of metastasis is an important component of an integrated approach to the management of patients with uveal melanoma, including organ-sparing treatment. State funding of this study will increase the satisfaction of psychological needs in this category of cancer patients and improve understanding of the metastasis of uveal melanoma.ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ (Π£Π) ΠΈΠΌΠ΅Π΅Ρ ΡΠ΅ΡΠ°ΡΡΠ΅Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π² ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΈΡΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. Π’Π°ΠΊΠΎΠΉ Π°Π½Π°Π»ΠΈΠ· Π²ΠΎΠ·ΠΌΠΎΠΆΠ΅Π½ Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΡΠΎΡ
ΡΠ°Π½ΡΡΡΠ΅Π³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π½Π° ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΡΠΎΠ½ΠΊΠΎΠΈΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π°ΡΠΏΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΈ (Π’ΠΠΠ), ΠΎΠ΄Π½Π°ΠΊΠΎ Π½Π΅ Π²ΡΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ ΠΌΠΎΠ³ΡΡ ΡΡΠΈΡΠ°ΡΡ Π΄Π°Π½Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ ΠΈ/ΠΈΠ»ΠΈ Π΄ΠΎΡΡΡΠΏΠ½ΡΠΌ.Π¦Π΅Π»Ρ: ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π£Π Π² ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ².ΠΠ°Π½Π½ΠΎΠ΅ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ 94 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π£Π (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ 60 Β± 13 Π»Π΅Ρ; 69 % ΠΆΠ΅Π½ΡΠΈΠ½ ΠΈ 31 % ΠΌΡΠΆΡΠΈΠ½).ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π²ΡΡΠΎΠΊΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΆΠ΅Π»Π°ΡΡΠΈΡ
(77 %), ΡΠΎΠ»ΡΠΊΠΎ ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Π° (51 %) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠΌ ΡΡΠ΅ΡΠ΅ Π±ΡΠ»ΠΈ ΡΠΎΠ³Π»Π°ΡΠ½Ρ Π½Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Β«ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉΒ» Π’ΠΠΠ, ΡΡΠΎ Π² ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠΎΠΈΠΌΠΎΡΡΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ (Π² 76 % ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΠΎΡΠΊΠ°Π·Π°). Π‘ΡΠ΅Π΄ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΌΠΎΡΠΈΠ²ΠΎΠ² ΠΆΠ΅Π»Π°Π½ΠΈΡ Π·Π½Π°ΡΡ ΡΠΈΡΠΊ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅: ΠΎΡΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠΈΡΡΠ°ΡΠΈΠΈ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅Ρ (78 %), ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΉ ΠΆΠΈΠ·Π½ΠΈ Π΄Π»Ρ ΡΠ΅Π±Ρ ΠΈ/ΠΈΠ»ΠΈ Π±Π»ΠΈΠ·ΠΊΠΈΡ
(47 %), Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΡΠ°ΡΡΠΈΡ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ°Ρ
Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΌΡ Π£Π (35 %), ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈ (28 %). ΠΠΎΡΠΈΠ²Ρ Π΄Π»Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΡ ΡΠ°ΠΊΠΎΠ³ΠΎ Π½Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ²ΡΠ·Π°Π½Ρ ΡΠΎ ΡΡΡΠ°Ρ
ΠΎΠΌ ΠΏΠ΅ΡΠ΅Π΄ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² ΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ.ΠΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΡΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ΅ΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° Π² Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠΎΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΡΠΎΡ
ΡΠ°Π½ΡΡΡΠ΅Π³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π±ΡΠ΄ΠΆΠ΅ΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠ΅ΠΉ Ρ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈ ΡΠ»ΡΡΡΠΈΡΡ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ
ΠΡΠ΅Π½ΠΊΠ° ΡΠΈΡΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Β«ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉΒ» ΡΠΎΠ½ΠΊΠΎΠΈΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π°ΡΠΏΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΈ ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ
Despite the widespread u se of fine-needle aspiration biopsy (FNAB) of uveal melanoma (UM) for prognostic purposes, there are still doubts about the safety of this procedure. No analysis of such data can be found in domestic literature, and foreign authors have published only a few papers on this issue.The purpose of this study is to analyze the risk of metastasis in patients with UM during FNAB.Two groups of patients were formed: the main group, where FNAB was performed during brachytherapy (BT) (BT + FNAB) (n = 70), and the control group, where only BT was performed (n = 144).According to the obtained data, the probability of metastases during a 3βyear follow-up period did not significantly differ between the two groups (p = 0.22 by Fisher's exact test and p = 0.11 by log-rank test when assessing survival using the Kaplan β Meier method), the relative risk (RR) was 1.43 [95 % CI 0.79 to 2.24]. In addition, there was no significant difference in the main clinical outcomes of local treatment associated with worse prognosis: the degree of tumor regression (p = 0.46), extrascleral growth, the need for additional brachytherapy (p = 0.32) or secondary enucleation (p = 0.99).The absence of a significant difference in patient survival between the BT and BT + FNAB groups opens up prospects for a more extensive use of FNAB in patients with UM for prognostic purposes.ΠΠ½Π½ΠΎΡΠ°ΡΠΈΡ: ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠ½ΠΊΠΎΠΈΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π°ΡΠΏΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΈ (Π’ΠΠΠ) ΡΠ²Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ (Π£Π) Ρ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π»ΡΡ, Π΄ΠΎ ΡΠΈΡ
ΠΏΠΎΡ Π²ΡΡΠΊΠ°Π·ΡΠ²Π°ΡΡΡΡ ΡΠΎΠΌΠ½Π΅Π½ΠΈΡ Π² Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΡΡΠΎΠΉ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ. ΠΡΠΈ ΡΡΠΎΠΌ Π² ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ Π°Π½Π°Π»ΠΈΠ· ΡΠ°ΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
Π½Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ, Π° ΡΡΠ΅Π΄ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
Π°Π²ΡΠΎΡΠΎΠ² ΠΏΠΎ ΡΡΠΎΠΉ ΡΠ΅ΠΌΠ΅ Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ Π»ΠΈΡΡ Π΅Π΄ΠΈΠ½ΠΈΡΠ½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ.Π¦Π΅Π»Ρ: ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠΈΡΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π£Π ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π’ΠΠΠ.ΠΡΠ»ΠΈ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Ρ 2 Π³ΡΡΠΏΠΏΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²: ΠΎΡΠ½ΠΎΠ²Π½Π°Ρ, Π³Π΄Π΅ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π±ΡΠ°Ρ
ΠΈΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΠ’) ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ Π’ΠΠΠ (ΠΠ’ + Π’ΠΠΠ) (n = 70), ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ, Π³Π΄Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΡΠΎΠ»ΡΠΊΠΎ ΠΠ’ (n = 144).Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌ Π΄Π°Π½Π½ΡΠΌ, Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ² Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ 3βΠ»Π΅ΡΠ½Π΅Π³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
Π½Π΅ ΠΈΠΌΠ΅Π΅Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΡΠ°Π·Π½ΠΈΡΡ (p = 0,22 ΠΏΠΎ ΡΠΎΡΠ½ΠΎΠΌΡ ΠΊΡΠΈΡΠ΅ΡΠΈΡ Π€ΠΈΡΠ΅ΡΠ° ΠΈ p = 0,11 ΠΏΠΎ Π»ΠΎΠ³Π°ΡΠΈΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΠ°Π½Π³ΠΎΠ²ΠΎΠΌΡ ΠΊΡΠΈΡΠ΅ΡΠΈΡ ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ°ΠΏΠ»Π°Π½Π° β ΠΠ°ΠΉΠ΅ΡΠ°), ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠΈΡΠΊ (RR) ΡΠΎΡΡΠ°Π²ΠΈΠ» 1,43 (95 % Π΄ΠΎΠ²Π΅ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π» ΠΎΡ 0,79 Π΄ΠΎ 2,24). ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΡΠ°Π·Π½ΠΈΡΡ ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π°: ΡΡΠ΅ΠΏΠ΅Π½Ρ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ (p = 0,46), ΡΠΊΡΡΡΠ°ΡΠΊΠ»Π΅ΡΠ°Π»ΡΠ½ΡΠΉ ΡΠΎΡΡ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π±ΡΠ°Ρ
ΠΈΡΠ΅ΡΠ°ΠΏΠΈΠΈ (p = 0,32) ΠΈΠ»ΠΈ Π²ΡΠΎΡΠΈΡΠ½ΠΎΠΉ ΡΠ½ΡΠΊΠ»Π΅Π°ΡΠΈΠΈ (p = 0,99).ΠΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΡΠ°Π·Π½ΠΈΡΡ Π² Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² Π³ΡΡΠΏΠΏΠ°Ρ
ΠΠ’ ΠΈ ΠΠ’ + Π’ΠΠΠ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π΄Π»Ρ Π±ΠΎΠ»Π΅Π΅ ΠΌΠ°ΡΡΡΠ°Π±Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π’ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π£Π Ρ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π»ΡΡ
Storage of Factor VIII Variants with Impaired von Willebrand Factor Binding in Weibel-Palade Bodies in Endothelial Cells
BACKGROUND: Point mutations resulting in reduced factor VIII (FVIII) binding to von Willebrand factor (VWF) are an important cause of mild/moderate hemophilia A. Treatment includes desmopressin infusion, which concomitantly increases VWF and FVIII plasma levels, apparently from storage pools containing both proteins. The source of these VWF/FVIII co-storage pools and the mechanism of granule biogenesis are not fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We studied intracellular trafficking of FVIII variants implicated in mild/moderate hemophilia A together with VWF in HEK293 cells and primary endothelial cells. The role of VWF binding was addressed using FVIII variants displaying reduced VWF interaction. Binding studies using purified FVIII proteins revealed moderate (Arg2150His, Del2201, Pro2300Ser) to severe (Tyr1680Phe, Ser2119Tyr) VWF binding defects. Expression studies in HEK293 cells and primary endothelial cells revealed that all FVIII variants were present within VWF-containing organelles. Quantitative studies showed that the relative amount of FVIII storage was independent of various mutations. Substantial amounts of FVIII variants are co-stored in VWF-containing storage organelles, presumably by virtue of their ability to interact with VWF at low pH. CONCLUSIONS: Our data suggest that the potential of FVIII co-storage with VWF is not affected in mild/moderate hemophilia A caused by reduced FVIII/VWF interaction in the circulation. These data support the hypothesis that Weibel-Palade bodies comprise the desmopressin-releasable FVIII storage pool in vivo
MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF NONISCHEMIC (ARTERIAL) PRIAPISM
The article analyzes information on prevalence, etiology, peculiarities of differential diagnosis, as well as indications and methods of surgical treatment of non-ischemic (arterial) priapism. The literature data are supplemented by the results of our own observations.The disease is characterized by a rarity and significant differences in therapeutic tactics in comparison with ischemic (venous) priapism. Arterial priapism occurs about 50 times less often than venous and in most cases is secondary to trauma of the penis, perineum or congenital abnormalities of the vessels of the penis. Primary, that is, unclear etiology, arterial priapism is described as a casuistic rarity.Laboratory-confirmed arterial priapism is a planned situation, not requiring immediate measures to stop the pathological erection, while the outcome of venous priapism directly depends on the duration of the disease and the success of emergency urological care.The main method of differential diagnosis of hemodynamic forms of priapism is the gasometry of blood obtained by puncture of cavernous bodies. The absence of hypoxia is a pathognomonic symptom of arterial priapism and serves as a rationale for angiography, the task of which is the topical diagnosis of vascular disorders.The revealed pathological vascular joints undergo superselective embolization. The effectiveness of the technique in terms of stopping the pathological erection is close to 100%.Surgical tactics do not depend on the etiology of arterial priapism: posttraumatic and βnon-traumaticβ variants of the disease imply an absolutely identical approach.ExpectantΒ tacticsΒ regardingΒ arterialΒ priapismΒ areΒ theΒ subjectΒ ofΒ scientificΒ discussion.Β DespiteΒ theΒ possibilityΒ of an independent cessation of pathological erection with arterial priapism, due to the risk of developing cavernous fibrosis, expectant management is appropriate only in children with undisputed posttraumatic etiology of the disease. The observation period should not exceed 3β4 weeks.The prognosis of arterial priapism is much better than venous. Arterial priapism, as well as endovascular methods of its treatment are not accompanied by the risk of acute cavernitis. Erectile function, provided the timeliness of the intervention is preserved in virtually all patients
Dilabifilum β like alga (Chlorophyta) from the seabord solonchak soils
Considered Dilabitfilum - as algae (Chlorophyta) from solonchak soils
Repeated phosphorescence and parameters of the electron trapping centers in Eu2+ -activated alkali halide phosphors
First examples of chalcofluoride rhenium cluster complexes with cubane like anions [Re4Q4F12]4- (Q = S, Se)
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