Equations of Transversal Vibration of a Two-Layer Viscoelastic Plate of Constant Thickness

This article discusses the analysis of the general equations of the transverse oscillation of a piecewise-homogeneous viscoelastic plate obtained in the "Oscillations of two-layer plates of constant thickness" article [1]. In this paper, on the basis of a mathematical method, an approximate theory of oscillation of piecewise homogeneous plates is developed, based on considering the plate as a three-dimensional body, on the exact formulation of the three-dimensional mathematical boundary value problem of oscillation under external forces causing transverse oscillations.The theoretical results obtained for solving dynamic problems of transverse vibrations of piecewise homogeneous two-layer plates of constant thickness, taking into account the viscous properties of their material, make it possible to more accurately calculate the stress-strain state of the plates under non-stationary external loads.In the present work on the basis of a mathematical method, the approached theory of fluctuation of the two-layer plates, based on plate consideration as three dimensional body, on exact statement of a three dimensional mathematical regional problem of fluctuation is stood at the external efforts causing cross-section fluctuations.The received theoretical results for the decision of dynamic problems of cross-section fluctuation of piecewise homogeneous two-layer plates of a constant thickness taking into account viscous properties of their material allow to count more precisely the is intense-deformed status of plates at non-stationary external loadings

The System of Mythological Characters in the Turkic Epic: The Karachay-Balkarian Nartiada and Yakut Olonkho

The article explores the parallels in the structure of character systems of the Karachay-Balkarian version of the Nartiada and Yakut heroic epos Olonkho. The main focus is on the typical attributes and plot functions of such groups of characters as celestial demiurges and protectors of epic heroes and their demonic antagonists. The research aims to assess the degree of typological proximity of the studied traditions based on the analysis of one of the levels of the system of epic characters. The article reveals the close connection of the plots of the Karachay-Balkarian Nartiada and the Yakut epic Olonkho with the ritual and mythological context. In both traditions, a similar circle of characters in structure and functions is revealed — the patrons of the hero, attributed as deities (тейри, айыы таҥара) and also represented in the real religious and mythological practice of the bearers of traditions. Noticeable coincidences in the plots of the Karachay-Balkarian and Yakut epics are also found in the field of demonological conceptions. They have such common features as the chthonic kind and monstrous appearance of the antagonists of the hero, the presence in the plots of an expressive image of the mother of epic demons. These features stem from the general typological properties of the archaic heroic epic. At the same time, such features as the serpentomorphism of the chthonic demoness and the ‘landscape’ semantics of tropes applied to antagonists can be considered as genetically related elements, possibly dating back to the proto-Turkic mythological worldview

Effect of hydrogen on the structure of quenched orthorhombic titanium aluminide-based alloy and phase transformations during subsequent heating

The effect of hydrogen on structure formation and changes in the volume fractions of phases in an alloy based on orthorhombic titanium aluminide (O phase) alloy upon its quenching is studied. X-ray diffraction analysis is used to determine the lattice parameters of phases. It has been shown that hydrogen is dissolved mainly in the β0 phase. Differential thermal analysis is used to determine stages and temperature ranges of phase transformations during heating; it was found that introduced hydrogen shifts the β0 → O and reverse O → β0 transformations into the low-temperature range; the enthalpies of transformation are calculated. © 2013 Pleiades Publishing, Ltd

Biomarkers of Air-Blood Barrier Damage In COVID-19

The search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important for a successful treatment.The aim of the study was to examine the association of molecular biomarkers of air-blood barrier damage, surfactant proteins SP-A and SP-D and Club cell protein CC16, with the outcome of patients with COVID-19.Materials and methods. A cohort of 109 patients diagnosed with COVID-19 was retrospectively divided into two groups. Group 1 comprised survivor patients discharged from the ICU (w=90). Group 2 included the patients who did not survive (w=19). Association of disease outcome and SP-A, SP-D, and CC16 levels in blood serum, clinical, and laboratory data were examined taking into account the day of illness at the time of biomaterial collection.Results. The non-survivors had higher SP-A (from days 1 to 10 of symptoms onset) and lower CC16 (from days 11 to 20 of symptoms onset) levels vs survivors discharged from ICU. No significant differences in SP-D levels between the groups were found.Conclusion. According to the study results, the surfactant protein SP-A and Club cell protein CC16 are associated with increased COVID-19 mortality

The nature and fate of natural resins in the geosphere. XII. Investigation of C-ring aromatic diterpenoids in Raritan amber by pyrolysis-GC-matrix isolation FTIR-MS

Upper Cretaceous amber from the Raritan Formation (Sayerville, New Jersey) has been investigated by Pyrolysis-GC-MS and Pyrolysis-GC-matrix isolation FTIR-MS. Results establish the existence of two distinct forms of amber in this deposit. Both forms are Class Ib ambers, but they are unambiguously differentiated on the basis of their (intact) diterpenoid composition. The presence of callitrisate in both forms, and cupraene in samples designated form 1, strongly suggest that both derive from related-but-distinct species within the Cupressaceae. In addition to callitrisate, dehydroabietate and analogous 17-nor-, 16,17-dinor- and 15,16,17-trinor- analogues of these compounds are also observed. The distributions of these products in multiple samples suggest that they are the result of biological emplacement, rather than diagenetic modification of the parent compounds. This indicates that the distributions of diterpenes observed in these samples are representative of the original bioterpenoids and, hence, are useful for chemotaxonomic analyses

Rare Variants in Primary Immunodeficiency Genes and Their Functional Partners in Severe COVID-19

The development of severe COVID-19, which is a complex multisystem disease, is thought to be associated with many genes whose action is modulated by numerous environmental and genetic factors. In this study, we focused on the ideas of the omnigenic model of heritability of complex traits, which assumes that a small number of core genes and a large pool of peripheral genes expressed in disease-relevant tissues contribute to the genetics of complex traits through interconnected networks. We hypothesized that primary immunodeficiency disease (PID) genes may be considered as core genes in severe COVID-19, and their functional partners (FPs) from protein–protein interaction networks may be considered as peripheral near-core genes. We used whole-exome sequencing data from patients aged ≤ 45 years with severe (n = 9) and non-severe COVID-19 (n = 11), and assessed the cumulative contribution of rare high-impact variants to disease severity. In patients with severe COVID-19, an excess of rare high-impact variants was observed at the whole-exome level, but maximal association signals were detected for PID + FP gene subsets among the genes intolerant to LoF variants, haploinsufficient and essential. Our exploratory study may serve as a model for new directions in the research of host genetics in severe COVID-19

Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations

Pelvic organ prolapse (POP) is a common highly disabling disorder with a large hereditary component. It is characterized by a loss of pelvic floor support that leads to the herniation of the uterus in or outside the vagina. Genome-wide linkage studies have shown an evidence of POP association with the region 9q21 and six other loci in European pedigrees. The aim of our study was to test the above associations in a case-control study in Russian population. Twelve SNPs including SNPs cited in the above studies and those selected using the RegulomeDB annotations for the region 9q21 were genotyped in 210 patients with POP (stages III-IV) and 292 controls with no even minimal POP. Genotyping was performed using the polymerase chain reaction with confronting two-pair primers (PCR–CTPP). Association analyses were conducted for individual SNPs, 9q21 haplotypes, and SNP-SNP interactions. SNP rs12237222 with the highest RegulomeDB score 1a appeared to be the key SNP in haplotypes associated with POP. Other RegulomeDB Category 1 SNPs, rs12551710 and rs2236479 (scores 1d and 1f, resp.), exhibited epistatic effects. In this study, we verified the region 9q21 association with POP in Russians, using RegulomeDB annotations