Finite Element Analysis of the Deformation of Functionally Graded Plates under Thermomechanical Loads

The first-order shear deformation plate model, accounting for the exact neutral plane position, is exploited to investigate the uncoupled thermomechanical behavior of functionally graded (FG) plates. Functionally graded materials are mainly constructed to operate in high temperature environments. Also, FG plates are used in many applications (such as mechanical, electrical, and magnetic), where an amount of heat may be generated into the FG plate whenever other forms of energy (electrical, magnetic, etc.) are converted into thermal energy. Several simulations are performed to study the behavior of FG plates, subjected to thermomechanical loadings, and focus the attention on the effect of the heat source intensity. Most of the previous studies have considered the midplane neutral one, while the actual position of neutral plane for functionally graded plates is shifted and should be firstly determined. A comparative study is performed to illustrate the effect of considering the neutral plane position. The volume fraction of the two constituent materials of the FG plate is varied smoothly and continuously, as a continuous power function of the material position, along the thickness of the plate

High-Power Wire Bonded GaN Rectifier for Wireless Power Transmission

A novel wire bonded GaN rectifier for high-power wireless power transfer (WPT) applications is proposed. The low breakdown voltage in silicon Schottky diodes limits the high-power operations of microwave rectifier. The proposed microwave rectifier consists of a high breakdown voltage GaN rectifying element for high-power operation and a novel low loss impedance matching technique for high efficiency performance. Wire bonding method is adopted to provide electrical connection between GaN chip and board which induces undesirable inductance. In order to realize high efficiency performance, an impedance matching network is proposed to exploit the unavoidable inductance along with a single shunt capacitor, resulting in a low loss matching circuit to achieve a compact high-power rectifier. The fabricated GaN rectifier exhibits a good performance in the high-power region and can withstand up to 39 dBm input power before reaching the breakdown limit at the operating frequency of 0.915 GHz and load resistance of 100 Ω. It has a compact size and exhibits high efficiency performance in high-power region (achieved a maximum efficiency of 61.2% at 39 dBm), making it suitable for high-power applications like future unmanned intelligent devices and WPT in space applications

Lightweight and low-loss 3-D printed millimeter-wave bandpass filter based on gap-waveguide

This paper presents a comprehensive study of a groove gap waveguide (also known as a waffle-iron) bandpass filter at Ka-band (26.5-40 GHz), fabricated using a high resolution polymer jetting (Polyjet) 3-D printing technology. The same filter was previously fabricated using brass CNC milling technology. The metalized Polyjet 3-D printed filter has lower loss, is lighter in weight and more cost-effective, when compared to the solid metal case. The filter operates at a center frequency of 35.65 GHz, has a 500 MHz bandwidth (1.4% fractional bandwidth), and has a transmission zero below and above the passband. Without any design iterations, the measured S-parameters for the Polyjet 3-D printed filter are presented and compared with simulated results, showing excellent agreement. A comparison is then made between the measured results and that of its brass machined counterpart. The new Polyjet 3-D printed filter is 85% lighter than the conventional machined version. All these features prove the important potential of 3-D printing technology for millimeter-wave applications, which includes aerospace

Age at diagnosis in women with non-metastatic breast cancer: Is it related to prognosis?

Objective: Primary objective was to verify whether breast cancer patients aged less than 40 years at diagnosis have poorer prognosis than older patients. Secondary to assess prognostic factors influencing disease free survival. Methods: 941 women were diagnosed with non-metastatic breast cancer at NCI, Cairo in 2003. Epidemiologic, clinico-pathological characteristics, treatment modalities and disease free survival were compared among the two age groups. Prognostic factors were evaluated for association with disease-free survival. Results: One hundred-eighty-one patients (19.2%) were younger than 40 years and 760 (80.8%) were older. Older women presented with higher rates of comorbidities and younger women presented with more hormone non-responsive tumors. Young women presented with larger tumors pT4 = 13.8% compared to 8.6% in older women, yet not significant. Young women were treated with more conservative surgery, more adjuvant chemotherapy and radiotherapy while older women with more radical mastectomies and more hormonal treatment. Recurrence rates were significantly higher among young women 44.2% compared to 34.5% in older women. Five year disease free survival in young women was 38.9% ± 4.6% compared to 48.6% ± 2.5% with adjusted hazard ratio of 1.22 95% CI (0.91–1.64), p = 0.19. Multivariate analyses identified positive axillary lymph nodes (pN2-pN3), larger tumor size (pT3-pT4), hypertension, lobular carcinoma type and lack of adjuvant systemic treatment as independent factors associated with poor DFS. Conclusion: Young women were not found to have poorer prognosis, yet they presented with more ER negative tumors. Most of women presented with advanced stage and young women had higher recurrence rates

Receptor-defined subtypes of breast cancer in indigenous populations in Africa: a systematic review and meta-analysis.

BACKGROUND: Breast cancer is the most common female cancer in Africa. Receptor-defined subtypes are a major determinant of treatment options and disease outcomes but there is considerable uncertainty regarding the frequency of poor prognosis estrogen receptor (ER) negative subtypes in Africa. We systematically reviewed publications reporting on the frequency of breast cancer receptor-defined subtypes in indigenous populations in Africa. METHODS AND FINDINGS: Medline, Embase, and Global Health were searched for studies published between 1st January 1980 and 15th April 2014. Reported proportions of ER positive (ER+), progesterone receptor positive (PR+), and human epidermal growth factor receptor-2 positive (HER2+) disease were extracted and 95% CI calculated. Random effects meta-analyses were used to pool estimates. Fifty-four studies from North Africa (n=12,284 women with breast cancer) and 26 from sub-Saharan Africa (n=4,737) were eligible. There was marked between-study heterogeneity in the ER+ estimates in both regions (I2>90%), with the majority reporting proportions between 0.40 and 0.80 in North Africa and between 0.20 and 0.70 in sub-Saharan Africa. Similarly, large between-study heterogeneity was observed for PR+ and HER2+ estimates (I2>80%, in all instances). Meta-regression analyses showed that the proportion of ER+ disease was 10% (4%-17%) lower for studies based on archived tumor blocks rather than prospectively collected specimens, and 9% (2%-17%) lower for those with ≥ 40% versus those with <40% grade 3 tumors. For prospectively collected samples, the pooled proportions for ER+ and triple negative tumors were 0.59 (0.56-0.62) and 0.21 (0.17-0.25), respectively, regardless of region. Limitations of the study include the lack of standardized procedures across the various studies; the low methodological quality of many studies in terms of the representativeness of their case series and the quality of the procedures for collection, fixation, and receptor testing; and the possibility that women with breast cancer may have contributed to more than one study. CONCLUSIONS: The published data from the more appropriate prospectively measured specimens are consistent with the majority of breast cancers in Africa being ER+. As no single subtype dominates in the continent availability of receptor testing should be a priority, especially for young women with early stage disease where appropriate receptor-specific treatment modalities offer the greatest potential for reducing years of life lost. Please see later in the article for the Editors' Summary