In vitro studies of antistress and antiallergic effects of semecarpus anacardium fruit in asthma

Semicarpus anacardium Linn. (Anacardiaceae) is a deciduous moderate sized tree. The plant is commonly known as Ballataka (Sanskrit), Bhela (Hindi) and marking nut in English. Fruits are acrid and sweet and used traditionally in the treatment of asthma. Allergy and stress are important contributing factors in asthma; hence, our objective was to study the effect of plant extracts on milk-induced leucocytosis (antistress) and milk-induced eosinophilia (antiallergic) as no work is done in this direction and to check a possible antiasthmatic role of the plant. Extracts were given at the dose of 50 and 100 mg/kg, p.o., to mice. Ethyl acetate and ethanol extracts showed significant decrease in leukocytes and eosinophils count. These results confirm the use of S. anacardium fruits as antistress and antiallergic agents in the treatment asthma.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis and microbiological evaluation of 2-acetanilido-4-arylthiazole derivatives

1929-1932A series of compounds have been synthesized by reacting 2-amino 4-arylthiazole with different substituted acetanilides and chloroacetylation of 2-amino 4-arylthiazole or their substituted derivatives. Ten different substituted compounds synthesized out of the 2-acetanilido 4-arylthiazole derivatives and 2-pyrazine 4-arylthiazole have been evaluated for the antifungal and antibacterial activities. These compounds have showed moderate antibacterial and very good activity

Synthesis and evaluation of some new substituted phenylthiazole derivatives and their antitubercular activity

1033-1037A new series of substituted phenylthiazole derivatives have been synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All compounds have been screened for antitubercular activity by Middle brook 7H9 agar medium against H37Rv. strain. Most of these compounds have shown promising antitubercular activity

Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity

1453-1456A series of 1,3,4-oxadiazole and pyrazole derivatives have been synthesized and evaluated for antitubercular activity. All the structures of the newly synthesized compounds have been supported by IR, 1H NMR, MS and CHN analysis. All the compounds have shown promising antitubercular activity when compared with the standard drug Streptomycin

Development and validation of HPTLC method to detect Curcumin and Gallic acid in polyherbal formulation

Curcumin and Gallic acid are one of the phytoconstituents present in Curcuma longa and Emblica officinalis, respectively. Both these plants are used traditionally in the treatment of cancer and for the treatment of leukemia. In the present study, an attempt has been made to develop a HPTLC method for quantitative estimation of curcumin and gallic acid in different anticancer polyherbal formulations. The method employed TLC aluminum plates precoated with silica gel 60 F-254 as the stationary phase. The solvent system consisted of chloroform: ethyl acetate: formic acid (7.5 mL\6mL\0.5 mL). This system was found to give compact spots for curcumin (Rf value of 0.55 +/- 0.02) and for gallic acid ( Rf value of 0.26 +/- 0.03). Densitometric analysis of curcumin and gallic acid were carried out in the absorbance mode at 254 nm. This HPTLC method was found to be reproducible, accurate, and can detect curcumin and gallic acid at a nanogram level. The developed HPTLC method would be an important tool in the quality control method for polyherbal formulations

Current biological and synthetic profile of Triazoles: A review

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