Influence of critical hypotension on the development of postoperative hepatic failure

The article is devoted to the study of influence of critical hypotension on the development of postoperative hepatic failure. The results of treatment of 54 patients who had. anatomical and advanced anatomical resections of a liver were analyzed. Also the causes that lead to the postoperative hepatic failure such as volume of intraoperative blood loss, duration of intraoperative hypotension were analyzed. As the result of the analysis of obtained data on the influence of studied parameters (volume of blood loss, duration. of vascular isolation and presence of intraoperative hypotension) on the development of hepatic failure in postoperative period we supposed that the most unfavorable prognostic sign of its appearance is an episode of critical decrease of arterial pressure during the operation. Thus even at massive blood loss hepatic failure doesn't always appear, whereas critical intraoperative hypotension causes its development. Taking into consideration data on the state of central hemodynamics at the performing of anatomic resections of liver we determined main approaches to the infusion-transfusion therapy during excluding of liver from blood circulation for the prophylactics of its reperfusion injuries. It was established that prophylactics and timely correction of critical intraoperative hypotenstion that is the main factor of development of postoperative hepatic failure should be considered as the key moments of intraoperative protection of hepatocytes

Outpatient technologies in policlinic department of regional oncology center

Ап experience of our day hospital at the polyclinic GBUZ CHOKOD that allows to solve the problem to improve the organization of specialized medical care, an increase in work intensity outpatient care clinic, increasing the availability and quality of specialized medical care.Приведен наш опыт организации дневного стационара при поликлинике ГБУЗ ЧОКОД, позволяющий решить задачу по совершенствованию организации специализированной медицинской помощи, увеличению интенсивности работы амбулаторно-поликлинических звена диспансера, повышению доступности и качества специализированной медицинской помощи

DEVELOPMENT OF A METHODOLOGY FOR ASSESSING THE VIABILITY OF MICROORGANISMS BY THE TURBIDIMETRIC METHOD

Turbidimetry - quantitative analysis of the composition and properties of substances, based on measuring the amount of light absorbed by a suspension. In our study, an attempt was made to create a method for assessing the viability of microorganisms by the turbidimetric method

New Religious Movements as a Form of Religious Organization, Ways and Factors of their Appearance and Function

Рассматривая понятие «новые религиозные движения» как альтернативный термин тоталитарным сектам и деструктивным культам, описываются их сходные характеристики, а также теоретические подходы к трактовке путей возникновения иных форм организации религии. Анализируются основные факторы появления, развития и функционирования новых религиозных движений, обосновываются кризисное состояние общества и социальная нестабильность как наиболее значимые. The article deals with new religious movements. The author compares the new religious movements with traditional forms of organization of religion. The concept of “new religious movements” is used as an alternative term of totalitarian sects and destructive cults. The basic characteristics of new religious movements consider. The main characteristics of similar new religious movements are described. The theoretical approaches of description of the ways formation of new religious movements are considered. It analyzes the main factors affecting the appearance of development and operation of new religious movements. Thus, a number of social, political, and religious factors that influence the development of new religious movements highlighted. Also, the crisis state of society is viewed as one of the possible factors of the origin, development and functioning of the new religious movements

Возможности использования Интернет при обучении иностранному языку

The possibilities of using Internet in teaching foreign languages in technical institutes are represented. Each stage of educational project aimed to develop communicative competence is considered. The peculiarities of teaching process with using Internet are taken into account.Представлены возможности использования Интернет при обучении иностранному языку в неязыковом вузе. Поэтапно рассмотрен учебный проект, нацеленный на развитие коммуникативной компетенции. В статье учитываются особенности учебного процесса с применением Интернет

Blood eosinophilia in patients with severe bronchial asthma and chronic polypous rhinosinusitis treated with dupilumab: A review

Bronchial asthma and chronic polypous rhinosinusitis are diseases associated with a T2-inflammatory immune response. These nosologies can be combined, creating the preconditions for a more severe course of multimorbidity, requiring the use of genetic engineering biological therapy. Dupilumab is a monoclonal antibody that can specifically bind to the alpha subunit of the interleukin-4 receptor and block the action of interleukins 4 and 13, which play a key role in the development of T2 inflammation. Numerous studies have demonstrated the high effectiveness of this medicament. The use of dupilumab in some cases may be accompanied by an increase in eosinophils in the blood. This article presents scientific base and our own experience in treating patients with dupilumab-associated eosinophilia, in addition we describe an algorithm for examining this group of patients for the purpose of timely diagnosis of diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic pneumonia, etc. It should be noted that in the most cases eosinophilia during targeted therapy with dupilumab is temporary and does not cause clinical manifestations

Mechanical Analogy-based Iterative Method for Solving a System of Linear Equations

The paper reviews prerequisites to creating a variety of the iterative methods to solve a system of linear equations (SLE). It considers the splitting methods, variation-type methods, projection-type methods, and the methods of relaxation.A new iterative method based on mechanical analogy (the movement without resistance of a material point, that is connected by ideal elastically-linear constraints with unending guides defined by equations of solved SLE). The mechanical system has the unique position of stable equilibrium, the coordinates of which correspond to the solution of linear algebraic equation. The model of the mechanical system is a system of ordinary differential equations of the second order, integration of which allows you to define the point trajectory. In contrast to the classical methods of relaxation the proposed method does not ensure a trajectory passage through the equilibrium position. Thus the convergence of the method is achieved through the iterative stop of a material point at the moment it passes through the next (from the beginning of the given iteration) minimum of potential energy. After that the next iteration (with changed initial coordinates) starts.A resource-intensive process of numerical integration of differential equations in order to obtain a precise law of motion (at each iteration) is replaced by defining its approximation. The coefficients of the approximating polynomial of the fourth order are calculated from the initial conditions, including higher-order derivatives. The resulting approximation enables you to evaluate the kinetic energy of a material point to calculate approximately the moment of time to reach the maximum kinetic energy (and minimum of the potential one), i.e. the end of the iteration.The software implementation is done. The problems with symmetric positive definite matrix, generated as a result of using finite element method, allowed us to examine a convergence rate of the proposed method. The proposed method has shown the comparable results with the most commonly used method of conjugate gradients. There are prospects for development of the proposed method, in particular through the preconditioned use.</p