О РАЗВИТИИ ЭКСПОРТНОГО ПОТЕНЦИАЛА РЕСПУБЛИКИ БЕЛАРУСЬ*

The paper deals with the export potential of the Republic of Belarus and the main directions of its development. Construction principles and the essence of the export potential, the role and value of which increases with the openness of national economies to the outside world are presented. Analyzed are the trends in the foreign trade of Belarus as well as the place of Belarus in the world market in respect of the production of basic goods, export and import of major agricultural raw materials and food, influencing factors of export development, measures and mechanisms of the export support including the government support. Proposals for improving the basic directions of the development of export potential of Belarus have been worked out to promote goods to foreign markets.В научной статье рассматривается экспортный потенциал Республики Беларусь, основные направления его развития. Показаны сущность экспортного потенциала, роль и значение которого возрастает по мере открытости национальных экономик государств внешнему миру, принципы построения. Проанализированы тенденции во внешней торговле товарами в Республике Беларусь; место Беларуси по выпуску основных товаров на мировом рынке; экспорт и импорт важнейших видов сельскохозяйственного сырья и продовольствия; сдерживающие факторы развития экспорта; меры и механизмы поддержки экспорта, в том числе механизм государственной поддержки. Разработаны предложения по совершенствованию направлений развития экспортного потенциала Республики Беларусь для активизации продвижения товаров на внешние рынки

Properties of elastomeric compositions with fluorinated additive

The effect of the product of pyrolytic synthesis Forum on the properties of the elastomer compositions based on EPDM rubber is investigated. It is established that introduction of modifying agent promotes viscosity reduction, cuts time attainment of optimum cure and improves the technical properties of vulcanizates

Technical properties of elastomer compositions on the basis of butadiyen-nitril of rubber modified by politetraftoretilen

The effect of PTFE F4 and the product of thermal gas-dynamic synthesis “Forum” on the technical properties of the elastomer compositions based on butadiene-nitrile rubber NBR-18 are investigated. The addition of modifying agents improves following characteristics: the heat-ageing resistance of vulcanized rubber, swelling resistance in hydrocarbon liquids and abrasion resistance of elastomeric compositions

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells

P2X7 receptors are ligand-gated ion channels activated by ATP and play a significant role in cellular immunity. These receptors are considered as a potential therapeutic target for the treatment of multiple inflammatory diseases. In the present work, using spectrofluorimetry, spectrophotometry, Western blotting and ELISA approaches, the ability of 1,4-naphthoquinone thioglucoside derivatives, compounds U-286 and U-548, to inhibit inflammation induced by ATP/LPS in RAW 264.7 cells via P2X7 receptors was demonstrated. It has been established that the selected compounds were able to inhibit ATP-induced calcium influx and the production of reactive oxygen species, and they also exhibited pronounced antioxidant activity in mouse brain homogenate. In addition, compounds U-286 and U-548 decreased the LPS-induced activity of the COX-2 enzyme, the release of pro-inflammatory cytokines TNF-α and IL-1β in RAW 264.7 cells, and significantly protected macrophage cells against the toxic effects of ATP and LPS. This study highlights the use of 1,4-naphthoquinones as promising purinergic P2X7 receptor antagonists with anti-inflammatory activity. Based on the data obtained, studied synthetic 1,4-NQs can be considered as potential scaffolds for the development of new anti-inflammatory and analgesic drugs