Deductive Reasoning and Social Anxiety:Evidence for a Fear-confirming Belief Bias

This study investigated the relationship between belief bias and fear of negative evaluation. Belief bias refers to a bias in deductive reasoning that acts to confirm rather than falsify prior beliefs. Participants (N = 52) with varying levels of fear of negative evaluation completed a belief bias task by means of linear syllogisms, with stimuli covering both social anxiety convictions and factual neutral statements. A linear relationship was found between fear of negative evaluation and belief bias for the social anxiety conviction category. No differences in reasoning were found for the neutral syllogisms. These results support the view that highly socially anxious individuals do not have a reasoning abnormality, but do have difficulty judging anxiogenic information as false and reassuring convictions-contradicting information as true. Such belief bias logically prevents dysfunctional cognitions from being corrected, thereby sustaining phobic fear

Transport Theoretical Approach to the Nucleon Spectral Function in Nuclear Matter

The nucleon spectral function in infinite nuclear matter is calculated in a quantum transport theoretical approach. Exploiting the known relation between collision rates and correlation functions the spectral function is derived self-consistently. By re-inserting the spectral functions into the collision integrals the description of hard processes from the high-momentum components of wave functions and interactions is improved iteratively until convergence is achieved. The momentum and energy distributions and the nuclear matter occupation probabilities are in very good agreement with the results obtained from many-body theory.Comment: minor changes in the text, additional curves in fig.

Star Clusters in the Nearby Late-Type Galaxy NGC 1311

Ultraviolet, optical and near infrared images of the nearby (D ~ 5.5 Mpc) SBm galaxy NGC 1311, obtained with the Hubble Space Telescope, reveal a small population of 13 candidate star clusters. We identify candidate star clusters based on a combination of their luminosity, extent and spectral energy distribution. The masses of the cluster candidates range from ~1000 up to ~100000 Solar masses, and show a strong positive trend of larger mass with increasing with cluster age. Such a trend follows from the fading and dissolution of old, low-mass clusters, and the lack of any young super star clusters of the sort often formed in strong starbursts. The cluster age distribution is consistent with a bursting mode of cluster formation, with active episodes of age ~10 Myr, ~100 Myr and ~1 Gyr. The ranges of age and mass we probe are consistent with those of the star clusters found in quiescent Local Group dwarf galaxies.Comment: 21 pages, 11 figures, accepted by A

Repeatability of two semi-automatic artificial intelligence approaches for tumor segmentation in PET

Background: Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metastasis) and/or total lesion glycolysis derived from PET images have been identified as prognostic factor or for the evaluation of treatment efficacy in cancer patients. To this end, a segmentation approach with high precision and repeatability is important. However, the implementation of a repeatable and accurate segmentation algorithm remains an ongoing challenge. Methods: In this study, we compare two semi-automatic artificial intelligence (AI)-based segmentation methods with conventional semi-automatic segmentation approaches in terms of repeatability. One segmentation approach is based on a textural feature (TF) segmentation approach designed for accurate and repeatable segmentation of primary tumors and metastasis. Moreover, a convolutional neural network (CNN) is trained. The algorithms are trained, validated and tested using a lung cancer PET dataset. The segmentation accuracy of both segmentation approaches is compared using the Jaccard coefficient (JC). Additionally, the approaches are externally tested on a fully independent test–retest dataset. The repeatability of the methods is compared with those of two majority vote (MV2, MV3) approaches, 41%SUVMAX, and a SUV > 4 segmentation (SUV4). Repeatability is assessed with test–retest coefficients (TRT%) and intraclass correlation coefficient (ICC). An ICC > 0.9 was regarded as representing excellent repeatability. Results: The accuracy of the segmentations with the reference segmentation was good (JC median TF: 0.7, CNN: 0.73). Both segmentation approaches outperformed most other conventional segmentation methods in terms of test–retest coefficient (TRT% mean: TF: 13.0%, CNN: 13.9%, MV2: 14.1%, MV3: 28.1%, 41%SUVMAX: 28.1%, SUV4: 18.1%) and ICC (TF: 0.98, MV2: 0.97, CNN: 0.99, MV3: 0.73, SUV4: 0.81, and 41%SUVMAX: 0.68). Conclusion: The semi-automatic AI-based segmentation approaches used in this study provided better repeatability than conventional segmentation approaches. Moreover, both algorithms lead to accurate segmentations for both primary tumors as well as metastasis and are therefore good candidates for PET tumor segmentation

When Is a Bulge Not a Bulge? Inner Disks Masquerading as Bulges in NGC 2787 and NGC 3945

We present a detailed morphological, photometric, and kinematic analysis of two barred S0 galaxies with large, luminous inner disks inside their bars. We show that these structures, in addition to being geometrically disk-like, have exponential profiles (scale lengths $\sim$ 300--500 pc) distinct from the central, non-exponential bulges. We also find them to be kinematically disk-like. The inner disk in NGC 2787 has a luminosity roughly twice that of the bulge; but in NGC 3945, the inner disk is almost ten times more luminous than the bulge, which itself is extremely small (half-light radius $\approx$ 100 pc, in a galaxy with an outer ring of radius $\approx$ 14 kpc) and only $\sim$ 5% of the total luminosity -- a bulge/total ratio much more typical of an Sc galaxy. We estimate that at least 20% of (barred) S0 galaxies may have similar structures, which means that their bulge/disk ratios may be significantly overestimated. These inner disks dominate the central light of their galaxies; they are at least an order of magnitude larger than typical ``nuclear disks'' found in ellipticals and early-type spirals. Consequently, they must affect the dynamics of the bars in which they reside.Comment: LaTeX, 37 pages, 14 EPS figures. To appear in The Astrophysical Journal (November 10, 2003 issue). Version with full-resolution figures available at http://www.iac.es/galeria/erwin/research

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation and differentiation to restore biliary epithelial integrity. However, formal evidence for this concept in human livers is lacking. We, therefore, developed a novel ex vivo model using precision-cut slices of extrahepatic human bile ducts obtained from discarded donor livers, providing an intact anatomical organization of cell structures, to study spatiotemporal differentiation and migration of PBG cells after severe biliary injury. Post-ischemic bile duct slices were incubated in oxygenated culture medium for up to a week. At baseline, severe tissue injury was evident with loss of luminal epithelial lining and mural stroma necrosis. In contrast, PBG remained relatively well preserved and different reactions of PBG were noted, including PBG dilatation, cell proliferation and maturation. Proliferation of PBG cells increased after 24 h of oxygenated incubation, reaching a peak after 72 h. Proliferation of PBG cells was paralleled by a reduction in PBG apoptosis and differentiation from a primitive and pluripotent (Nanog+/Sox9+) to a mature (CFTR+/secretin receptor+) and activated phenotype (increased expression of HIF-1α, Glut-1, and VEGF-A). Migration of proliferating PBG cells in our ex vivo model was unorganized, but resulted in generation of epithelial monolayers at stromal surfaces. CONCLUSION: Human PBG contain biliary progenitor cells and are able to respond to bile duct epithelial loss with proliferation, differentiation, and maturation to restore epithelial integrity. The ex vivo spatiotemporal behaviour of human PBG cells provides evidence for a pivotal role of PBG in biliary regeneration after severe injury. This article is protected by copyright. All rights reserved

Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses

Herpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises (Phocoena phocoena), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus (Phocoena phocoena herpesvirus type 1, PPHV-1) - a gammaherpesvirus - and two novel herpesviruses (PPHV-2 and PPHV-3) - both alphaherpesviruses - in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor

Особенности трансформации символа креста на территории средневековой Таврики

BACKGROUND: Cow's milk-derived whey hydrolysates are nutritional substitutes for allergic infants. Safety or residual allergenicity assessment of these whey hydrolysates is crucial. Currently, rat basophilic leukemia RBL-2H3 cells expressing the human IgE receptor α-chain (huFcεRIα-RBL-2H3), sensitized with serum IgE from cow's milk allergic children, are being employed to assess in vitro residual allergenicity of these whey hydrolysates. However, limited availability and inter-lot variation of these allergic sera impede standardization of whey hydrolysate safety testing in degranulation assays. OBJECTIVE: An oligoclonal pool of chimeric human (chu)IgE antibodies against bovine β-lactoglobulin (a major allergen in whey) was generated to increase sensitivity, specificity, and reproducibility of existing degranulation assays. METHODS: Mice were immunized with bovine β-lactoglobulin, and subsequently the variable domains of dissimilar anti-β-lactoglobulin mouse IgG antibodies were cloned and sequenced. Six chimeric antibodies were generated comprising mouse variable domains and human constant IgE/κ domains. RESULTS: After sensitization with this pool of anti-β-lactoglobulin chuIgEs, huFcεRIα-expressing RBL-2H3 cells demonstrated degranulation upon cross-linking with whey, native 18 kDa β-lactoglobulin, and 5-10 kDa whey hydrolysates, whereas a 3 kDa whey hydrolysate and cow's milk powder (mainly casein) showed no degranulation. In parallel, allergic serum IgEs were less sensitive. In addition, our pool anti-β-lactoglobulin chuIgEs recognized multiple allergenic immunodominant regions on β-lactoglobulin, which were also recognized by serum IgEs from cow's milk allergic children. CONCLUSION: Usage of our 'unlimited' source and well-defined pool of β-lactoglobulin-specific recombinant chuIgEs to sensitize huFcεRIα on RBL-2H3 cells showed to be a relevant and sensitive alternative for serum IgEs from cow's milk allergic patients to assess safety of whey-based non-allergic hydrolyzed formula

A Highly Redundant BAC Library of Atlantic salmon (Salmo salar): An Important Tool for Salmon Projects

Background: As farming of Atlantic salmon is growing as an aquaculture enterprise, the need to identify thegenomic mechanisms for specific traits is becoming more important in breeding and management of the animal.Traits of importance might be related to growth, disease resistance, food conversion efficiency, color or taste.To identify genomic regions responsible for specific traits, genomic large insert libraries have previously provento be of crucial importance. These large insert libraries can be screened using gene or genetic markers in orderto identify and map regions of interest. Furthermore, large-scale mapping can utilize highly redundant libraries ingenome projects, and hence provide valuable data on the genome structure.Results: Here we report the construction and characterization of a highly redundant bacterial artificialchromosome (BAC) library constructed from a Norwegian aquaculture strain male of Atlantic salmon (Salmosalar). The library consists of a total number of 305 557 clones, in which approximately 299 000 are recombinants.The average insert size of the library is 188 kbp, representing 18-fold genome coverage. High-density filters eachconsisting of 18 432 clones spotted in duplicates have been produced for hybridization screening, and are publiclyavailable [1]. To characterize the library, 15 expressed sequence tags (ESTs) derived overgos and 12 oligosequences derived from microsatellite markers were used in hybridization screening of the complete BAC library.Secondary hybridizations with individual probes were performed for the clones detected. The BACs positive forthe EST probes were fingerprinted and mapped into contigs, yielding an average of 3 contigs for each probe.Clones identified using genomic probes were PCR verified using microsatellite specific primers.Conclusion: Identification of genes and genomic regions of interest is greatly aided by the availability of theCHORI-214 Atlantic salmon BAC library. We have demonstrated the library\u27s ability to identify specific genes andgenetic markers using hybridization, PCR and fingerprinting experiments. In addition, multiple fingerprintingcontigs indicated a pseudo-tetraploidity of the Atlantic salmon genome. The highly redundant CHORI-214 BAClibrary is expected to be an important resource for mapping and sequencing of the Atlantic salmon genome