Engaging Stakeholder Communities as Body Image Intervention Partners: The Body Project as a Case Example

Despite recent advances in developing evidence-based psychological interventions, substantial changes are needed in the current system of intervention delivery to impact mental health on a global scale (Kazdin & Blase, 2011). Prevention offers one avenue for reaching large populations because prevention interventions often are amenable to scaling-up strategies, such as task-shifting to lay providers, which further facilitate community stakeholder partnerships. This paper discusses the dissemination and implementation of the Body Project, an evidence-based body image prevention program, across 6 diverse stakeholder partnerships that span academic, non-profit and business sectors at national and international levels. The paper details key elements of the Body Project that facilitated partnership development, dissemination and implementation, including use of community-based participatory research methods and a blended train-the-trainer and task-shifting approach. We observed consistent themes across partnerships, including: sharing decision making with community partners, engaging of community leaders as gatekeepers, emphasizing strengths of community partners, working within the community\u27s structure, optimizing non-traditional and/or private financial resources, placing value on cost-effectiveness and sustainability, marketing the program, and supporting flexibility and creativity in developing strategies for evolution within the community and in research. Ideally, lessons learned with the Body Project can be generalized to implementation of other body image and eating disorder prevention programs

Is the Blade Element Momentum theory overestimating wind turbine loads? – An aeroelastic comparison between OpenFAST's AeroDyn and QBlade's Lifting-Line Free Vortex Wake method

Abstract. Load calculations play a key role in determining the design loads of different wind turbine components. To obtain the aerodynamic loads for these calculations, the industry relies heavily on the Blade Element Momentum (BEM) theory. BEM methods use several engineering correction models to capture the aerodynamic phenomena present in Design Load Cases (DLCs) with turbulent wind. Because of this, BEM methods can overestimate aerodynamic loads under challenging conditions when compared to higher-order aerodynamic methods – such as the Lifting-Line Free Vortex Wake (LLFVW) method – leading to unnecessarily high design loads and component costs. In this paper, we give a quantitative answer to the question of load overestimation of a particular BEM implementation by comparing the results of aeroelastic load calculations done with the BEM-based OpenFAST code and the QBlade code, which uses a particular implementation of the LLFVW method. We compare extreme and fatigue load predictions from both codes using sixty-six 10 min load simulations of the Danish Technical University (DTU) 10 MW Reference Wind Turbine according to the IEC 61400-1 power production DLC group. Results from both codes show differences in fatigue and extreme load estimations for the considered sensors of the turbine. LLFVW simulations predict 9 % lower lifetime damage equivalent loads (DELs) for the out-of-plane blade root and the tower base fore–aft bending moments compared to BEM simulations. The results also show that lifetime DELs for the yaw-bearing tilt and yaw moments are 3 % and 4 % lower when calculated with the LLFVW code. An ultimate state analysis shows that extreme loads of the blade root out-of-plane bending moment predicted by the LLFVW simulations are 3 % lower than the moments predicted by BEM simulations. For the maximum tower base fore–aft bending moment, the LLFVW simulations predict an increase of 2 %. Further analysis reveals that there are two main contributors to these load differences. The first is the different way both codes treat the effect of the nonuniform wind field on the local blade aerodynamics. The second is the higher average aerodynamic torque in the LLFVW simulations. It influences the transition between operating modes of the controller and changes the aeroelastic behavior of the turbine, thus affecting the loads

The 2.3 GHz continuum survey of the GEM project

We present a partial-sky survey of the radio continuum at 2.3 GHz within the scope of the Galactic Emission Mapping (GEM) project, an observational program conceived and developed to reveal the large-scale properties of Galactic synchrotron radiation through a set of self-consistent surveys of the radio continuum between 408 MHz and 10 GHz. The GEM experiment uses a portable and double-shielded 5.5-m radiotelescope in altazimuthal configuration to map 60-degree-wide declination bands from different observational sites by circularly scanning the sky at zenithal angles of 30 deg from a constantly rotating platform. The observations were accomplished with a total power receiver, whose front-end High Electron Mobility Transistor (HEMT) amplifier was matched directly to a cylindrical horn at the prime focus of the parabolic reflector. The Moon was used to calibrate the antenna temperature scale and the preparation of the map required direct subtraction and destriping algorithms to remove ground contamination as the most significant source of systematic error. We used 484 hours of total intensity observations from two locations in Colombia and Brazil to yield 66% sky coverage from DEC = -51.73 deg to DEC = +34.78 deg. The zero-level uncertainty of the combined survey is 103 mK with a temperature scale error of 5% after direct correlation with the Rhodes/HartRAO survey at 2326 MHz on a T-T plot. The sky brightness distribution into regions of low and high emission in the GEM survey is consistent with the appearance of a transition region as seen in the Haslam 408 MHz and WMAP K-band surveys. Preliminary results also show that the temperature spectral index between 408 MHz and the 2.3 GHz band of the GEM survey has a weak spatial correlation with these regions; but it steepens significantly from high to low emission regions with respect to the WMAP K-band survey.Comment: 20 pages, 21 figures, 6 tables. Extensively revised and enlarged version accepted for publication in Astronomy & Astrophysics. Smaller figure

Daily rice bran consumption for 6 months influences serum glucagon-like peptide 2 and metabolite profiles without differences in trace elements and heavy metals in weaning nicaraguan infants at 12 months of age

Background: Environmental enteric dysfunction (EED) is associated with chronic gut inflammation affecting nutrient absorption and development of children, primarily in low- and middle-income countries. Several studies have shown that rice bran (RB) supplementation provides nutrients and modulates gut inflammation, which may reduce risk for undernutrition. Objective: The aim was to evaluate the effect of daily RB dietary supplementation for 6 mo on serum biomarkers in weaning infants and associated changes in serum and stool metabolites. Methods: A 6-mo randomized-controlled dietary intervention was conducted in a cohort of weaning 6-mo-old infants in León, Nicaragua. Anthropometric indices were obtained at 6, 8, and 12 mo. Serum and stool ionomics and metabolomics were completed at the end of the 6-mo intervention using inductively coupled plasma MS and ultra-high performance LC-tandem MS. The α1-acid glycoprotein, C-reactive protein, and glucagon-like peptide 2 (GLP-2) serum EED biomarkers were measured by ELISA. Results: Twenty-four infants in the control group and 23 in the RB group successfully completed the 6-mo dietary intervention with 90% dietary compliance. RB participants had higher concentrations of GLP-2 as compared with control participants at 12 mo [median (IQR): 743.53 (380.54) pg/mL vs. 592.50 (223.59) pg/mL; P = 0.04]. Metabolite profiles showed significant fold differences of 39 serum metabolites and 44 stool metabolites from infants consuming RB compared with control, and with significant metabolic pathway enrichment scores of 4.7 for the tryptophan metabolic pathway, 5.7 for polyamine metabolism, and 5.7 for the fatty acid/acylcholine metabolic pathway in the RB group. No differences were detected in serum and stool trace elements or heavy metals following daily RB intake for 6 mo. Conclusions: RB consumption influences a suite of metabolites associated with growth promotion and development, while also supporting nutrient absorption as measured by changes in serum GLP-2 in Nicaraguan infants. This clinical trial was registered at https://clinicaltrials.gov as NCT02615886

Characterization of enterotoxigenic Escherichia coli strains isolated from Nicaraguan children in hospital, primary care and community settings

Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of diarrhoea among young children in developing countries. ETEC vaccines offer promise in reducing the burden of ETEC disease, but the development of these vaccines relies on the characterization of ETEC isolates from a variety of settings. To best reflect the full spectrum of ETEC disease in León, Nicaragua, the aim of this study was to characterize ETEC strains isolated from children with diarrhoea attending different settings (hospital, primary care clinics and in the community) and children from different age groups. We characterized ETEC isolates in terms of their colonization factors (CFs) and enterotoxins, and determined whether these factors varied with setting and age group. Diarrhoeal stool samples were obtained from children under the age of 60 months from: (1) the regional public hospital, (2) four public primary care clinics, and (3) a population-based cohort. In total, 58 ETEC-positive isolates were analysed by multiplex-PCR assays for the identification of CFs (CS1, CS2, CS3, CS4, CS5, CS6, CS7, CS8, CS12, CS13, CS14, CS15, CS17, CS18, CS19, CS20, CS21, CS22 and CFA/I), and enterotoxins [heat-labile toxin (LT) and heat-stable variants STh and STp]. The frequency of CFs and enterotoxins was compared among the three settings and for different age groups, using Fisher’s exact test or a χ2 test. At least one CF was detected among one-half of samples; CS19 was detected among all strains in which a CF was identified, either alone or in combination with another CF. Among all CFs detected, 91.7 % were identified as members of the class 5 fimbrial family. CFs were detected more commonly among samples from infants captured in the health facility setting compared with the community setting. Overall, LT was detected among 67.2 % of samples, STh was detected among 20.7 % and both enterotoxins were detected among 12.1 %. The enterotoxin STh was detected more commonly among cases in the community, whilst a combination of STh and LT was detected more commonly among cases treated in health facilities. Our results suggest that, to protect against diarrhoeal cases associated with this E. coli pathotype in León, Nicaragua, an ETEC vaccine that effectively targets the archeotype CFA/I of the class 5 fimbrial family would be the most effective in this setting

Few-anyon systems in a parabolic dot

The energy levels of two and three anyons in a two-dimensional parabolic quantum dot and a perpendicular magnetic field are computed as power series in 1/|J|, where J is the angular momentum. The particles interact repulsively through a coulombic (1/r) potential. In the two-anyon problem, the reached accuracy is better than one part in 10^5. For three anyons, we study the combined effects of anyon statistics and coulomb repulsion in the ``linear'' anyonic states.Comment: LaTeX, 6 pages, 4 postscript figure

Transiting Disintegrating Planetary Debris around WD 1145+017

More than a decade after astronomers realized that disrupted planetary material likely pollutes the surfaces of many white dwarf stars, the discovery of transiting debris orbiting the white dwarf WD 1145+017 has opened the door to new explorations of this process. We describe the observational evidence for transiting planetary material and the current theoretical understanding (and in some cases lack thereof) of the phenomenon.Comment: Invited review chapter. Accepted March 23, 2017 and published October 7, 2017 in the Handbook of Exoplanets. 15 pages, 10 figure

Lepton Masses from a TeV Scale in a 3-3-1 Model

In this work, using the fact that in 3-3-1 models the same leptonic bilinear contributes to the masses of both charged leptons and neutrinos, we develop an effective operator mechanism to generate mass for all leptons. The effective operators have dimension five for the case of charged leptons and dimension seven for neutrinos. By adding extra scalar multiplets and imposing the discrete symmetry $Z_9\otimes Z_2$ we are able to generate realistic textures for the leptonic mixing matrix. This mechanism requires new physics at the TeV scale.Comment: RevTex, 13 pages. Extended version to be published in Physical Review

African American patients with gout: efficacy and safety of febuxostat vs allopurinol

<p>Abstract</p> <p>Background</p> <p>African Americans are twice as likely as Caucasians to develop gout, but they are less likely to be treated with urate-lowering therapy (ULT). Furthermore, African Americans typically present with more comorbidities associated with gout, such as hypertension, obesity, and renal impairment. We determined the efficacy and safety of ULT with febuxostat or allopurinol in African American subjects with gout and associated comorbidities and in comparison to Caucasian gout subjects.</p> <p>Methods</p> <p>This is a secondary analysis of the 6-month Phase 3 CONFIRMS trial. Eligible gouty subjects with baseline serum urate (sUA) ≥ 8.0 mg/dL were randomized 1:1:1 to receive febuxostat 40 mg, febuxostat 80 mg, or allopurinol (300 mg or 200 mg depending on renal function) daily. All subjects received gout flare prophylaxis. Primary efficacy endpoint was the proportion of subjects in each treatment group with sUA < 6.0 mg/dL at the final visit. Additional endpoints included the proportion of subjects with mild or with moderate renal impairment who achieved a target sUA < 6.0 mg/dL at final visit. Adverse events (AEs) were recorded throughout the study.</p> <p>Results</p> <p>Of the 2,269 subjects enrolled, 10.0% were African American and 82.1% were Caucasian. African American subjects were mostly male (89.5%), obese (BMI ≥ 30 kg/m²; 67.1%), with mean baseline sUA of 9.8 mg/dL and mean duration of gout of 10.4 years. The proportions of African American subjects with a baseline history of diabetes, renal impairment, or cardiovascular disease were significantly higher compared to Caucasians (<it>p </it>< 0.001). ULT with febuxostat 80 mg was superior to both febuxostat 40 mg (<it>p </it>< 0.001) and allopurinol (<it>p </it>= 0.004). Febuxostat 40 mg was comparable in efficacy to allopurinol. Significantly more African American subjects with mild or moderate renal impairment achieved sUA < 6.0 mg/dL in the febuxostat 80 group than in either the febuxostat 40 mg or allopurinol group (<it>p </it>< 0.05). Efficacy rates in all treatment groups regardless of renal function were comparable between African American and Caucasian subjects, as were AE rates.</p> <p>Conclusions</p> <p>In African American subjects with significant comorbidities, febuxostat 80 mg is significantly more efficacious than either febuxostat 40 mg or allopurinol 200/300 mg. Febuxostat was well tolerated in this African American population.</p> <p>Please see related article: <url>http://www.biomedcentral.com/1741-7015/10/15</url></p

Association between gut microbiome composition and rotavirus vaccine response among Nicaraguan infants

Rotavirus is the leading cause of childhood deaths due to diarrhea. Although existing oral rotavirus vaccines are highly efficacious in high-income countries, these vaccines have been demonstrated to have decreased efficacy in low- and middle-income countries. A possible explanation for decreased efficacy is the impact of gut microbiota on the enteric immune system's response to vaccination. We analyzed the gut microbiome of 50 children enrolled in a prospective study evaluating response to oral pentavalent rotavirus vaccination (RV5) to assess associations between relative abundance of bacterial taxa and seroconversion following vaccination. Stool samples were taken before the first RV5 dose, and microbiome composition characterized using 16S rRNA amplicon sequencing and Quantitative Insights Into Microbial Ecology software. Relative abundance of bacterial taxa between seroconverters following the first RV5 dose, those with 3 4-fold increase in rotavirus-specific IgA titers, and nonseroconverters were compared using the Wilcoxon-Mann-Whitney test. We identified no significant differences in microbiome composition between infants who did and did not respond to vaccination. Infants who responded to vaccination tended to have higher abundance of Proteobacteria and Eggerthella, whereas those who did not respond had higher abundance of Fusobacteria and Enterobacteriaceae; however, these differences were not statistically significant following a multiple comparison correction. This study suggests a limited impact of gut microbial taxa on response to oral rotavirus vaccination among infants; however, additional research is needed to improve our understanding of the impact of gut microbiome on vaccine response, toward a goal of improving vaccine efficacy and rotavirus prevention