New South Wales Vegetation classification and Assessment: Part 3, plant communities of the NSW Brigalow Belt South, Nandewar and west New England Bioregions and update of NSW Western Plains and South-western Slopes plant communities, Version 3 of the NSWVCA database

This fourth paper in the NSW Vegetation Classification and Assessment series covers the Brigalow Belt South-/1(BBS) and Nandewar (NAN) Bioregions and the western half of the New England Bioregion (NET), an area of 9.3 million hectares being 11.6% of NSW. It completes the NSWVCA coverage for the Border Rivers-Gwydir and Namoi CMA areas and records plant communities in the Central West and Hunter–Central Rivers CMA areas. In total, 585 plant communities are now classified in the NSWVCA covering 11.5 of the 18 Bioregions in NSW (78% of the State). Of these 226 communities are in the NSW Western Plains and 416 are in the NSW Western Slopes. 315 plant communities are classified in the BBS, NAN and west-NET Bioregions including 267 new descriptions since Version 2 was published in 2008. Descriptions of the 315 communities are provided in a 919 page report on the DVD accompanying this paper along with updated reports on other inland NSW bioregions and nine Catchment Management Authority areas fully or partly classified in the NSWVCA to date. A read-only version of Version 3 of the NSWVCA database is on the DVD for use on personal computers. A feature of the BBS and NAN Bioregions is the array of ironbark and bloodwood Eucalyptusdominated shrubby woodlands on sandstone and acid volcanic substrates extending from Dubbo to Queensland. This includes iconic natural areas such as Warrumbungle and Mount Kaputar National Parks and the 500,000 ha Pilliga Scrub forests. Large expanses of basalt-derived soils support grassy box woodland and native grasslands including those on the Liverpool Plains; near Moree; and around Inverell, most of which are cleared and threatened. Wetlands occur on sodic soils near Yetman and in large clay gilgais in the Pilliga region. Sedgelands are rare but occupy impeded creeks. Aeolian lunettes occur at Narran Lake and near Gilgandra. Areas of deep sand contain Allocasuarina, eucalypt mallee and Melaleuca uncinata heath. Tall grassy or ferny open forests occur on mountain ranges above 1000m elevation in the New England Bioregion and on the Liverpool Range while grassy box woodlands occupy lower elevations with lower rainfall and higher temperatures. The vegetation classification and assessment is based on over 100 published and unpublished vegetation surveys and map unit descriptions, expert advice, extra plot sampling and data analysis and over 25 000 km of road traverse with field checking at 805 sites. Key sources of data included floristic analyses produced in western regional forest assessments in the BBS and NAN Bioregions, floristic analyses in over 60 surveys of conservation reserves and analysis of plot data in the western NET Bioregion and covering parts of the Namoi and Border Rivers- Gwydir CMA areas. Approximately 60% of the woody native vegetation in the study area has been cleared resulting in large areas of “derived” native grasslands. As of June 2010, 7% of the area was in 136 protected areas and 127 of the 315 plant communities were assessed to be adequately protected in reserves. Using the NSWVCA database threat criteria, 15 plant communities were assessed as being Critically Endangered, 59 Endangered, 60 Vulnerable, 99 Near Threatened and 82 Least Concern. 61 of these communities are assessed as part of NSW or Commonwealth-listed Threatened Ecological Communities. Current threats include expanding dryland and irrigated cropping on alluvial plains, floodplains and gently undulating topography at lower elevations; over-grazing of steep hills; altered water tables and flooding regimes; localized mining; and the spread of exotic species, notably Coolatai Grass (Hyparrhenia hirta)

Generating Focussed Molecule Libraries for Drug Discovery with Recurrent Neural Networks

In de novo drug design, computational strategies are used to generate novel molecules with good affinity to the desired biological target. In this work, we show that recurrent neural networks can be trained as generative models for molecular structures, similar to statistical language models in natural language processing. We demonstrate that the properties of the generated molecules correlate very well with the properties of the molecules used to train the model. In order to enrich libraries with molecules active towards a given biological target, we propose to fine-tune the model with small sets of molecules, which are known to be active against that target. Against Staphylococcus aureus, the model reproduced 14% of 6051 hold-out test molecules that medicinal chemists designed, whereas against Plasmodium falciparum (Malaria) it reproduced 28% of 1240 test molecules. When coupled with a scoring function, our model can perform the complete de novo drug design cycle to generate large sets of novel molecules for drug discovery.Comment: 17 pages, 17 figure

Designing a more inclusive world

This paper summarises the what, why and how of inclusive design, and presents key contributions of the 2006–2010 i~design research consortium, the third successive research consortium funded by the Engineering and Physical Sciences Research Council as part of the Extending Quality of Life initiative. Throughout 10 years of i~design research, the overarching goals have been to provide industrial decision makers with mechanisms for understanding the significance of age- and capability-related factors, and to provide the design community with the techniques and guidance required to deliver better products and services for people of all ages and abilities. In this latest period of research, the specific emphasis has been on quantifying design exclusion and enabling designers to work with users

Multiple and complex links between babyWASH and stunting: An evidence synthesis

Studies have shown linkages between water, sanitation and hygiene (WASH) and stunting in children under 2 years in sub-Saharan Africa. WASH interventions have been shown to reduce stunting rates; however, the biological mechanisms and socio-economic influences responsible for this trend remain poorly understood. This paper reviews the literature regarding these links, and the efficacy of both general WASH interventions and those targeted at children in their first 1,000 days, known as babyWASH, for stunting reduction. Fifty-nine papers published between 2008 and 2019 were reviewed, retrieved from Science Direct, Scopus and Web of Science databases, comprising field trials and data analysis, and literature and systematic reviews. Key findings showed that stunting is directly attributed to diarrhoea, environmental enteric dysfunction and undernutrition although a more comprehensive understanding of these biological mechanisms is necessary. Interventions to interrupt the faecal transmission cycle proved to effectively reduce stunting rates, particularly improved sanitation facilities to reduce open defaecation, increased proximity to water and widespread behavioural change. Methodologies should move away from randomised controlled trials towards selected contexts, mixed data collection methods and inclusion of broader social, cultural and environmental conditions. Improved cross-sectoral collaboration is encouraged, particularly to ensure the complexity of social and contextual factors is fully considered

Thermodynamic and dynamic anomalies for a three dimensional isotropic core-softened potential

Using molecular dynamics simulations and integral equations (Rogers-Young, Percus-Yevick and hypernetted chain closures) we investigate the thermodynamic of particles interacting with continuous core-softened intermolecular potential. Dynamic properties are also analyzed by the simulations. We show that, for a chosen shape of the potential, the density, at constant pressure, has a maximum for a certain temperature. The line of temperatures of maximum density (TMD) was determined in the pressure-temperature phase diagram. Similarly the diffusion constant at a constant temperature, $D$, has a maximum at a density $\rho_{max}$ and a minimum at a density $\rho_{min}<\rho_{max}$. In the pressure-temperature phase-diagram the line of extrema in diffusivity is outside of TMD line. Although in this interparticle potential lacks directionality, this is the same behavior observed in SPC/E water.Comment: 16 page

“Free Will and Affirmation: Assessing Honderich’s Third Way”

In the third and final part of his A Theory of Determinism (TD) Ted Honderich addresses the fundamental question concerning “the consequences of determinism.” The critical question he aims to answer is what follows if determinism is true? This question is, of course, intimately bound up with the problem of free will and, in particular, with the question of whether or not the truth of determinism is compatible or incompatible with the sort of freedom required for moral responsibility. It is Honderich’s aim to provide a solution to “the problem of the consequences of determinism” and a key element of this is his articulation and defence of an alternative response to the implications of determinism that collapses the familiar Compatibilist/Incompatibilist dichotomy. Honderich offers us a third way – the response of “Affirmation” (HFY 125-6). Although his account of Affirmation has application and relevance to issues and features beyond freedom and responsibility, my primary concern in this essay will be to examine Honderich’s theory of “Affirmation” as it concerns the free will problem

EquiFACS: the Equine Facial Action Coding System

Although previous studies of horses have investigated their facial expressions in specific contexts, e.g. pain, until now there has been no methodology available that documents all the possible facial movements of the horse and provides a way to record all potential facial configurations. This is essential for an objective description of horse facial expressions across a range of contexts that reflect different emotional states. Facial Action Coding Systems (FACS) provide a systematic methodology of identifying and coding facial expressions on the basis of underlying facial musculature and muscle movement. FACS are anatomically based and document all possible facial movements rather than a configuration of movements associated with a particular situation. Consequently, FACS can be applied as a tool for a wide range of research questions. We developed FACS for the domestic horse (Equus caballus) through anatomical investigation of the underlying musculature and subsequent analysis of naturally occurring behaviour captured on high quality video. Discrete facial movements were identified and described in terms of the underlying muscle contractions, in correspondence with previous FACS systems. The reliability of others to be able to learn this system (EquiFACS) and consistently code behavioural sequences was high—and this included people with no previous experience of horses. A wide range of facial movements were identified, including many that are also seen in primates and other domestic animals (dogs and cats). EquiFACS provides a method that can now be used to document the facial movements associated with different social contexts and thus to address questions relevant to understanding social cognition and comparative psychology, as well as informing current veterinary and animal welfare practices

Public awareness of cancer in Britain: a population-based survey of adults

*_Objective:_* To assess public awareness of cancer warning signs, anticipated delay, and perceived barriers to seeking medical advice in the British population. &#xd;&#xa;Methods: We carried out a population-based survey using face-to-face, computer-assisted interviews to administer the Cancer Awareness Measure (CAM), a newly-developed, validated measure of cancer awareness. The sample included 2216 adults (970 male and 1246 female) recruited as part of the Office for National Statistics Opinions Survey using stratified probability sampling.&#xd;&#xa;&#xd;&#xa;*_Results:_* Awareness of cancer warning signs was low when open-ended (recall) questions were used and higher with closed (recognition) questions; but on either measure, awareness was lower in those who were male, younger, and from lower socioeconomic status (SES) groups or ethnic minorities. The most commonly endorsed barriers to help-seeking were difficulty making an appointment, worry about wasting the doctor&#x2019;s time and worry about what would be found. Emotional barriers were more prominent in lower SES groups and practical barriers (e.g. too busy) more prominent in higher SES groups. Anticipated delay was lower in ethnic minority and lower SES groups. In multivariate analysis, higher symptom awareness was associated with lower anticipated delay, and more barriers with greater anticipated delay.&#xd;&#xa;&#xd;&#xa;*_Conclusions:_* A combination of public education about symptoms and empowerment to seek medical advice, as well as support at primary care level, could enhance early presentation and improve cancer outcomes

Diagnosing observation error correlations for Doppler radar radial winds in the Met Office UKV model using observation-minus-background and observation-minus-analysis statistics

With the development of convection-permitting numerical weather prediction the efficient use of high-resolution observations in data assimilation is becoming increasingly important. The operational assimilation of these observations, such as Doppler radar radial winds (DRWs), is now common, though to avoid violating the assumption of uncorrelated observation errors the observation density is severely reduced. To improve the quantity of observations used and the impact that they have on the forecast requires the introduction of the full, potentially correlated, error statistics. In this work, observation error statistics are calculated for the DRWs that are assimilated into the Met Office high-resolution UK model using a diagnostic that makes use of statistical averages of observation-minus-background and observation-minus-analysis residuals. This is the first in-depth study using the diagnostic to estimate both horizontal and along-beam observation error statistics. The new results obtained show that the DRW error standard deviations are similar to those used operationally and increase as the observation height increases. Surprisingly the estimated observation error correlation length-scales are longer than the operational thinning distance. They are dependent both on the height of the observation and on the distance of the observation away from the radar. Further tests show that the long correlations cannot be attributed to the background error covariance matrix used in the assimilation, although they are, in part, a result of using superobservations and a simplified observation operator. The inclusion of correlated error statistics in the assimilation allows less thinning of the data and hence better use of the high-resolution observations