Metamorphism of cordierite gneisses from Eastern Ghat Granulite Terrain, Andhra Pradesh, South India

Cordierite-bearing metapelites of the Eastern Ghat granulite terrain occur in close association of Khondalites, quartzites, calc-silicate rocks and charnockites. Rocks occurring between Bobbili in the north and Guntur in the south of Andhra Pradesh are studied. The association of the mineral and textural relationships suggest the following metamorphic reactions: Garnet + sillimanite + quartz = cordierite, hypersthene + sillimanite + quartz = cordierite, sillimanite + spinel = cordierite + corundum, and biotite + quartz + sillimanite = cordierite + K=feldspar. Generally the minerals are not chemically zoned except garnet-biotite showing zoning when they come in close contact with one another. The potential thermometers are provided by the Fe-Mg distribution of coexisting biotite-garnet and cordierite-garnet. Conflicting interpretation of the P/T dependence of these reactions involving cordierite are due to H2O in the cordierite. The presence of alkali feldspar-quartz assemblage which is common in these gneisses will be constrained from melting only if H2O activity is less than 0.5. The piezometric array inferred is convex towards the temperature array, indicating a rapid and isothermal crustal uplift probably aided by thrust tectonics

Cefixime and Ofloxacin fixed dose combination induced petechial rash: a case report

Petechial rash is a type of rash which is associated with many infectious and non-infectious conditions. We present a case of Petechial rash induced by administration of cefixime with ofloxacin tablet. A eighteen year old male patient reported to us with a presentation of rash with itching for three days on administration of the fixed dose combination of cefixime + ofloxacin along with paracetamol for the previous symptoms of fever with chills, headache and bodyache. Patient describes itching in the rash which is increasing. The duty doctor attended the patient and immediately stopped the further administration of the offending medication. The patient was prescribed tablet cetirizine orally along with calamine lotion for local application. The patient reported back in for follow-up and was without any residual rashes or other such complaints. He was advised to remember and cautious from the use of drugs in the offending category

Negative modulation of alkaline phosphatase and creatine kinase by homobrassinolide

Homobrassinolide is a plant hormone implicated in plant growth and development. Its effect on animal metabolism was less known to date. We have investigated its effect on the marker enzymes such as alkaline phosphatase and creatine kinase in selected rat tissues-brain, heart, liver, kidney, skeletal muscle and testis. Homobrassinolide was administered (66 and 330ng/ Kg body weight) intradermally in male albino wistar strain rats and changes in alkaline phosphatase and creatine kinase activities were measured. An overall reduction in both the enzyme activities occurred within 2hr of administration with few exceptions. The reaction rate constants for the enzyme activities were in the order 10-7 mM/min for alkaline phosphatase and 10-3 mM/min for creatine kinase. Time course studies indicated a decrease in enzyme activities as a function of time. Elevated hemoglobin content correlated with rise in erythrocyte number. Blood glucose level decreased by a percentage of 15.7 and 21.7 compared to control with the administration of 10μg and 50μg homobrassinolide respectively. Serum cholesterol content showed 15% decrease and 25% increase compared to control following 10μg and 50μg homobrassinolide administration. We conclude that homobrassinolide inhibited both the enzymes in the tissues and produced erythrocytosis, leukocytosis and hypoglycemia, while cellular phosphorylation status remained principally affected by this oxysterol in rat. Even though the physiological and pathological significance of these observations is not clear, it is suggested that 28-HB enriched diets may not be appropriate for higher energy related work activities.Keywords: Alkaline phosphatase; Creatine kinase; Homobrassinolide; Oxysterol; Phosphorylation; Rate constant

Optimal corrosive behaviour on the weldment of AA6063 aluminum alloy by tungsten inert gas (TIG) welding process with backing plates

Pertaining on the present work on improving the corrosion resistance of AA 6063 aluminum alloy is found to weld with many backing plate materials like stainless steel, copper, marble and brass in accordance to the welding process that inherits itself with TIG. Utilizing the Orthogonal array L16, experiments were carried out. The corrosion resistance was improved by optimizing the pulsed TIG welding process parameters like current (A), gas flow rate (B), backing material (C) and backing thickness (D) using Genetic Algorithm (GA). Results proved that the GA shows a better corrosion resistance rate that was obtained to about 0,0408 mm/year with the backing material as copper

Negative modulation of alkaline phosphatase and creatine kinase by homobrassinolide

Homobrassinolide is a plant hormone implicated in plant growth and development. Its effect on animal metabolism was less known to date. We have investigated its effect on the marker enzymes such as alkaline phosphatase and creatine kinase in selected rat tissues-brain, heart, liver, kidney, skeletal muscle and testis. Homobrassinolide was administered (66 and 330ng/ Kg body weight) intradermally in male albino wistar strain rats and changes in alkaline phosphatase and creatine kinase activities were measured. An overall reduction in both the enzyme activities occurred within 2hr of administration with few exceptions. The reaction rate constants for the enzyme activities were in the order 10-7 mM/min for alkaline phosphatase and 10-3 mM/min for creatine kinase. Time course studies indicated a decrease in enzyme activities as a function of time. Elevated hemoglobin content correlated with rise in erythrocyte number. Blood glucose level decreased by a percentage of 15.7 and 21.7 compared to control with the administration of 10μg and 50μg homobrassinolide respectively. Serum cholesterol content showed 15% decrease and 25% increase compared to control following 10μg and 50μg homobrassinolide administration. We conclude that homobrassinolide inhibited both the enzymes in the tissues and produced erythrocytosis, leukocytosis and hypoglycemia, while cellular phosphorylation status remained principally affected by this oxysterol in rat. Even though the physiological and pathological significance of these observations is not clear, it is suggested that 28-HB enriched diets may not be appropriate for higher energy related work activities.Keywords: Alkaline phosphatase; Creatine kinase; Homobrassinolide; Oxysterol; Phosphorylation; Rate constant