Synthesis of molybdenum oxide nanoparticles by nanosecond laser ablation

Phothermal therapy (PTT) is one of the most promising techniques to treat cancer. Finding the ideal PTT agent nanomaterial has remained a challenge and has brought the interest of several researchers. In this work, we report the synthesis of molybdenum oxide (MoOx) nanoparticles (NPs), which exhibit absorption in the biological optical window ~840 nm, by using the laser ablation of solids in liquids (LASL) technique with nanosecond (ns) pulses. A Nd:YAG laser was used to synthesize the NPs in deionized (DI) water, free of surfactants or additives, which were optically characterized by absorption spectroscopy and TEM-EDX microscopy. Semi spherical NPs with a suitable average size and shape for potential use as PTT agents were obtained by laser ablation and ablation + fragmentation. The calculated band gap is 3.1 eV, which corresponds to MoO3. Micro-Raman spectroscopy studies determined that these NPs are composed of amorphous molybdenum oxide hydrates (MoO3 · xH2O)

Mediators of mechanotransduction between bone cells

Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and by decreasing its size in response to decreases in mechanical load associated with microgravity or prolonged bed rest. Changes in bone size and shape are produced by a cooperative action of two main types of the bone cells - osteoclasts that destroy bone and osteoblasts that build bone. These cell types come from different developmental origins, and vary greatly in their characteristics, such as size, shape, and expression of receptor subtypes, which potentially may affect their responses to mechanical stimuli. The objective of this study is to compare the responses of osteoclasts and osteoblasts to mechanical stimulation. This study has allowed us to conclude the following: 1. A mediator is released from a single source cell. 2. The response to the mediator changes with distance. 3. The value of the apparent diffusion coeficient increases with distance. 4. A plausible proposed mechanism is that ATP is released and degrades to ADP. 5. Future experiments are required to confim that ATP is the mediator as suggested

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study

Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors for poorer prognosis will decrease the rate of disease progression. The aim was to provide pilot data to evaluate preliminary effects and sample size calculation for a definitive clinical trial

How large is the spreading width of a superdeformed band?

Recent models of the decay out of superdeformed bands can broadly be divided into two categories. One approach is based on the similarity between the tunneling process involved in the decay and that involved in the fusion of heavy ions, and builds on the formalism of nuclear reaction theory. The other arises from an analogy between the superdeformed decay and transport between coupled quantum dots. These models suggest conflicting values for the spreading width of the decaying superdeformed states. In this paper, the decay of superdeformed bands in the five even-even nuclei in which the SD excitation energies have been determined experimentally is considered in the framework of both approaches, and the significance of the difference in the resulting spreading widths is considered. The results of the two models are also compared to tunneling widths estimated from previous barrier height predictions and a parabolic approximation to the barrier shape

Continuous-wave phase-sensitive parametric image amplification

We study experimentally parametric amplification in the continuous regime using a transverse-degenerate type-II Optical Parametric Oscillator operated below threshold. We demonstrate that this device is able to amplify either in the phase insensitive or phase sensitive way first a single mode beam, then a multimode image. Furthermore the total intensities of the amplified image projected on the signal and idler polarizations are shown to be correlated at the quantum level.Comment: 14 pages, 7 figures, submitted to Journal of Modern Optics, Special Issue on Quantum Imagin

Hydra tropomyosin TROP1 is expressed in head-specific epithelial cells and is a major component of the cytoskeletal structure that anchors nematocytes

A cDNA clone encoding a 253 amino acid tropomyosin was isolated from Hydra in a differential screen for headspecific genes. The Hydra tropomyosin gene, designated trop1, is a single copy gene, lacks introns and is strongly expressed in tentacle-specific epithelial cells. Analysis of protein synthesis in head and gastric tissue indicated a high rate of tropomyosin synthesis in head tissue. Immunolocalization of tropomyosin in tentacle tissue revealed a cushion-like tropomyosin-containing structure within battery cells at the base of nematocytes. The structure appears to form part of the cytoskeletal anchor for nematocytes. Tropomyosin cushions were also observed in epithelial cells along the body column, which contain mounted stenotele nematocytes