Statistical Constraints on State Preparation for a Quantum Computer

Quantum computing algorithms require that the quantum register be initially present in a superposition state. To achieve this, we consider the practical problem of creating a coherent superposition state of several qubits. Owing to considerations of quantum statistics, this requires that the entropy of the system go down. This, in turn, has two practical implications: (i) the initial state cannot be controlled; (ii) the temperature of the system must be reduced. These factors, in addition to decoherence and sensitivity to errors, must be considered in the implementation of quantum computers.Comment: 7 pages; the final published versio

AMP-CAD: Automatic Assembly Motion Planning Using C AD Models of Parts

Assembly with robots involves two kinds of motions, those that are point-to-point and those that are force/torque guided, the former kind of motions being faster and more amenable to automatic planning and the latter kind being necessary for dealing with tight clearances. In this paper, we describe an assembly motion planning system that uses descriptions of assemblies and CAD models of parts to automatically figure out which motions should be point-to-point and which motions should be force/torque guided. Our planner uses graph search over a potential field representation of parts to calculate candidate assembly paths. Given the tolerances of the parts and other uncertainties, these paths are then analyzed for the likelihood of collisions. Those path segments that are prone to collisions are then marked for execution under force/torque control. The calculation of the various motions is facilitated by an object-oriented and feature-based assembly representation. A highlight of this representation is the manner in which tolerance information is taken into account: Representation of, say, a part contains a pointer to the boundary representation of the part in its most material condition form. As first defined by Requicha, the most material condition form of a geometric entity is obtained by expanding all the convexities and shrinking all the concavities by relevant tolerances. An integral part of the assembly motion planner is the execution unit. Residing in this unit is knowledge of the different types of automatic EDR (error detection and recovery) strategies. Therefore, during the execution of the force/torque guided motion, this unit invokes the EDR strategies appropriate to the geometric constraints relevant to the motion. This system, called AMP-CAD, has been experimentally verified using a Cincinnati Milacron T3-726 robot and a Puma 762 robot on a variety of assemblies

Can coarse-graining introduce long-range correlations in a symbolic sequence?

We present an exactly solvable mean-field-like theory of correlated ternary sequences which are actually systems with two independent parameters. Depending on the values of these parameters, the variance on the average number of any given symbol shows a linear or a superlinear dependence on the length of the sequence. We have shown that the available phase space of the system is made up a diffusive region surrounded by a superdiffusive region. Motivated by the fact that the diffusive portion of the phase space is larger than that for the binary, we have studied the mapping between these two. We have identified the region of the ternary phase space, particularly the diffusive part, that gets mapped into the superdiffusive regime of the binary. This exact mapping implies that long-range correlation found in a lower dimensional representative sequence may not, in general, correspond to the correlation properties of the original system.Comment: 10 pages including 1 figur

Diffraction microtomography with sample rotation: influence of a missing apple core in the recorded frequency space

Diffraction microtomography in coherent light is foreseen as a promising technique to image transparent living samples in three dimensions without staining. Contrary to conventional microscopy with incoherent light, which gives morphological information only, diffraction microtomography makes it possible to obtain the complex optical refractive index of the observed sample by mapping a three-dimensional support in the spatial frequency domain. The technique can be implemented in two configurations, namely, by varying the sample illumination with a fixed sample or by rotating the sample using a fixed illumination. In the literature, only the former method was described in detail. In this report, we precisely derive the three-dimensional frequency support that can be mapped by the sample rotation configuration. We found that, within the first-order Born approximation, the volume of the frequency domain that can be mapped exhibits a missing part, the shape of which resembles that of an apple core. The projection of the diffracted waves in the frequency space onto the set of sphere caps covered by the sample rotation does not allow for a complete mapping of the frequency along the axis of rotation due to the finite radius of the sphere caps. We present simulations of the effects of this missing information on the reconstruction of ideal objects.Comment: 7 pages, 11 figures, presented at Focus On Microscopy 200

Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography

Purpose: This study investigated the effect of drug-excipient miscibility on the heterogeneity and spatial distribution of phase separation in pharmaceutical solid dispersions at a micron-scale using two novel and complementary characterization techniques, thermal analysis by structural characterization (TASC) and X-ray micro-computed tomography (XCT) in conjunction with conventional characterization methods. Method: Complex dispersions containing felodipine, TPGS, PEG and PEO were prepared using hot melt extrusion-injection moulding. The phase separation behavior of the samples was characterized using TASC and XCT in conjunction with conventional thermal, microscopic and spectroscopic techniques. The in vitro drug release study was performed to demonstrate the impact of phase separation on dissolution of the dispersions. Results: The conventional characterization results indicated the phase separating nature of the carrier materials in the patches and the presence of crystalline drug in the patches with the highest drug loading (30% w/w). TASC and XCT where used to provide insight into the spatial configuration of the separate phases. TASC enabled assessment of the increased heterogeneity of the dispersions with increasing the drug loading. XCT allowed the visualization of the accumulation of phase separated (crystalline) drug clusters at the interface of air pockets in the patches with highest drug loading which led to poor dissolution performance. Semi-quantitative assessment of the phase separated drug clusters in the patches were attempted using XCT. Conclusion: TASC and XμCT can provide unique information regarding the phase separation behavior of solid dispersions which can be closely associated with important product quality indicators such as heterogeneity and microstructure

Adapting “MOVE” to accelerate VMMC coverage for HIV prevention in priority populations:Implementation experiences from Uganda’s military settings

This paper describes the WHO’s Model of Optimizing Volumes and Efficiencies (MOVE), adapted by the University Research Council (URC) - Department of Defense HIV/AIDS Prevention Program (DHAPP) to rapidly scale up Voluntary Medical Male Circumcision (VMMC) within Uganda’s military health facilities. First, we examine the MOVE model and then present the URC-DHAPP adapted intervention package comprising of: a) a Command-driven approach, b) Mobile theatres c) Quality assurance d) Data strengthening and reflection. To expand VMMC, URC-DHAPP worked with army commanders to create awareness, mobilize their troops and surgeons were assigned daily targets. The mobile theatre involved regular visits to hard-to-reach outposts and placing several mobile camps at health facilities close to deployment sites. All stakeholders were briefed on performance trends of previous medical camps and the program was monitored through VMMC camp reports. URC-DHAPP registered an exponential increase in VMMC coverage from 13% performance at Q2 to over 140% in Q4. The integrated approach led to circumcision of over 22,000 men (15-49 years) in a record four months. Our approach also contributed to health system strengthening and national HIV preventiontargets. We conclude that the MOVE is cost-effective and can be successfully scaled up in resource-limited settings with a high HIV burden when implemented with cognizance of contextual specificities

Microscopic Optical Projection Tomography In Vivo

We describe a versatile optical projection tomography system for rapid three-dimensional imaging of microscopic specimens in vivo. Our tomographic setup eliminates the in xy and z strongly asymmetric resolution, resulting from optical sectioning in conventional confocal microscopy. It allows for robust, high resolution fluorescence as well as absorption imaging of live transparent invertebrate animals such as C. elegans. This system offers considerable advantages over currently available methods when imaging dynamic developmental processes and animal ageing; it permits monitoring of spatio-temporal gene expression and anatomical alterations with single-cell resolution, it utilizes both fluorescence and absorption as a source of contrast, and is easily adaptable for a range of small model organisms

Atomic super-resolution tomography

We consider the problem of reconstructing a nanocrystal at atomic resolution from electron microscopy images taken at a few tilt angles. A popular reconstruction approach called discrete tomography confines the atom locations to a coarse spatial grid, which is inspired by the physical a priori knowledge that atoms in a crystalline solid tend to form regular lattices. Although this constraint has proven to be powerful for solving this very under-determined inverse problem in many cases, its key limitation is that, in practice, defects may occur that cause atoms to deviate from regular lattice positions. Here we propose a grid-free discrete tomography algorithm that allows for continuous deviations of the atom locations similar to super-resolution approaches for microscopy. The new formulation allows us to define atomic interaction potentials explicitly, which results in a both meaningful and powerful incorporation of the available physical a priori knowledge about the crystal's properties. In computational experiments, we compare the proposed grid-free method to established grid-based approaches and show that our approach can indeed recover the atom positions more accurately for common lattice defects

Application of X-ray micro-computed tomography on high-speed cavitating diesel fuel flows

The flow inside a purpose built enlarged single-orifice nozzle replica is quantified using time-averaged X-ray micro-computed tomography (micro-CT) and high-speed shadowgraphy. Results have been obtained at Reynolds and cavitation numbers similar to those of real-size injectors. Good agreement for the cavitation extent inside the orifice is found between the micro-CT and the corresponding temporal mean 2D cavitation image, as captured by the high-speed camera. However, the internal 3D structure of the developing cavitation cloud reveals a hollow vapour cloud ring formed at the hole entrance and extending only at the lower part of the hole due to the asymmetric flow entry. Moreover, the cavitation volume fraction exhibits a significant gradient along the orifice volume. The cavitation number and the needle valve lift seem to be the most influential operating parameters, while the Reynolds number seems to have only small effect for the range of values tested. Overall, the study demonstrates that use of micro-CT can be a reliable tool for cavitation in nozzle orifices operating under nominal steady-state conditions