Development of a bedrest muscle stress apparatus

In attempting further to define the deleterious effects of spaceflight on the human body, measurement systems and techniques were devised to determine the loss of skeletal muscle strength and tone as a result of spaceflight exposure. In order to determine how the muscle degradation process progresses with time during nonuse, a system for measuring muscle stress during bedrest was developed. The Bedrest Muscle Stress Apparatus is configured to slip snugly over the foot board of a standard hospital bed. Data collected with this device correlated well with pre- and post-bedrest data collected with the original skeletal muscle stress apparatus

Pseudomoduli Dark Matter

We point out that pseudomoduli -- tree-level flat directions that often accompany dynamical supersymmetry breaking -- can be natural candidates for TeV-scale dark matter in models of gauge mediation. The idea is general and can be applied to different dark matter scenarios, including (but not limited to) those of potential relevance to recent cosmic ray anomalies. We describe the requirements for a viable model of pseudomoduli dark matter, and we analyze two example models to illustrate the general mechanism -- one where the pseudomoduli carry Higgsino-like quantum numbers, and another where they are SM singlets but are charged under a hidden-sector $U(1)'$ gauge group.Comment: 20 pages, refs adde

Attenuation of lung graft reperfusion injury by a nitric oxide donor

AbstractObjective: One of the primary features of ischemia-reperfusion injury is reduced production of protective autocoids, such as nitric oxide, by dysfunctional endothelium. Administration of a nitric oxide donor during reperfusion of lung grafts may therefore be beneficial through modulation of vascular tone and leukocyte and platelet function. Methods: Rat lung grafts were flushed with University of Wisconsin solution and reperfused for 1 hour in an ex vivo model incorporating a support animal. Group I grafts (n = 6) were reperfused immediately after explantation, group II (n = 6) and III (n = 5) grafts after 24 hours of storage at 4° C. In group III, glyceryl trinitrate, a nitric oxide donor, was administered during the first 10 minutes of reperfusion at a rate of 200 μg/min. In an additional group (n = 5), 200 μg/min hydralazine was administered instead, to assess the effect of vasodilation alone. Results: Graft function in group II deteriorated compared with that in group I, with significant reduction of graft effluent oxygen tension and blood flow and elevation of pulmonary artery pressure, peak airway pressure, and wet/dry weight ratio. In contrast, in group III, glyceryl trinitrate treatment improved graft function to baseline levels in all these parameters. Administration of hydralazine, meanwhile, produced mixed results with only two out of five grafts functioning at control levels. Conclusions: In this model, administration of glyceryl trinitrate to supplement the nitric oxide pathway in the early phase of reperfusion has a sustained beneficial effect on lung graft function after 24-hour hypothermic storage, probably through mechanisms beyond vasodilation alone. (J Thorac Cardiovasc Surg 1997;113:327-34

Kaluza-Klein Dark Matter, Electrons and Gamma Ray Telescopes

Kaluza-Klein dark matter particles can annihilate efficiently into electron-positron pairs, providing a discrete feature (a sharp edge) in the cosmic $e^+ e^-$ spectrum at an energy equal to the particle's mass (typically several hundred GeV to one TeV). Although this feature is probably beyond the reach of satellite or balloon-based cosmic ray experiments (those that distinguish the charge and mass of the primary particle), gamma ray telescopes may provide an alternative detection method. Designed to observe very high-energy gamma-rays, ACTs also observe the diffuse flux of electron-induced electromagnetic showers. The GLAST satellite, designed for gamma ray astronomy, will also observe any high energy showers (several hundred GeV and above) in its calorimeter. We show that high-significance detections of an electron-positron feature from Kaluza-Klein dark matter annihilations are possible with GLAST, and also with ACTs such as HESS, VERITAS or MAGIC.Comment: 10 pages, 2 figure

Spinless photon dark matter from two universal extra dimensions

We explore the properties of dark matter in theories with two universal extra dimensions, where the lightest Kaluza-Klein state is a spin-0 neutral particle, representing a six-dimensional photon polarized along the extra dimensions. Annihilation of this 'spinless photon' proceeds predominantly through Higgs boson exchange, and is largely independent of other Kaluza-Klein particles. The measured relic abundance sets an upper limit on the spinless photon mass of 500 GeV, which decreases to almost 200 GeV if the Higgs boson is light. The phenomenology of this dark matter candidate is strikingly different from Kaluza-Klein dark matter in theories with one universal extra dimension. Elastic scattering of the spinless photon with quarks is helicity suppressed, making its direct detection challenging, although possible at upcoming experiments. The prospects for indirect detection with gamma rays and antimatter are similar to those of neutralinos. The rates predicted at neutrino telescopes are below the sensitivity of next-generation experiments.Comment: 22 pages. Figure 7 corrected, leading to improved prospects for direct detection. Some clarifying remarks include

Reduced or modified dietary fat for preventing cardiovascular disease

BACKGROUND: Reduction or modification of dietary fat can improve total cholesterol levels, but may also have a variety of effects, both positive and negative, on other cardiovascular risk factors. OBJECTIVES: The aim of this systematic review was to assess the effect of reduction or modification of dietary fats on total and cardiovascular mortality and cardiovascular morbidity over at least 6 months, using all available randomized clinical trials. SEARCH STRATEGY: The Cochrane Library, MEDLINE, EMBASE, CAB Abstracts, CVRCT registry and related Cochrane Groups' trial registers were searched through spring 1998, SIGLE to January 1999. Trials known to experts in the field and biographies were included through May 1999. SELECTION CRITERIA: Trials fulfilled the following criteria: 1) randomized with appropriate control group, 2) intention to reduce or modify fat or cholesterol intake (excluding exclusively omega-3 fat interventions), 3) not multi factorial, 4) healthy adult humans, 5) intervention at least six months, 6) mortality or cardiovascular morbidity data available. Inclusion decisions were duplicated, disagreement resolved by discussion or a third party. DATA COLLECTION AND ANALYSIS: Rate data were extracted by two independent reviewers and meta-analysis performed using random effects methodology. Meta-regression and funnel plots were used. MAIN RESULTS: Twenty seven studies were included (40 intervention arms, 30,901 person-years). There was no significant effect on total mortality (rate ratio 0.98, 95% CI 0.86 to 1.12), a trend towards protection form cardiovascular mortality (rate ratio 0.91, 95% CI 0.77 to 1.07), and significant protection from cardiovascular events (rate ratio 0.84, 95% CI 0.72 to 0.99). The latter became non-significant on sensitivity analysis. Trials where participants were involved for more than 2 years showed significant reductions in the rate of cardiovascular events and a suggestion of protection from total mortality. The degree of protection from cardiovascular events appeared similar in high and low risk groups, but was statistically significant only in the former. REVIEWER'S CONCLUSIONS: The findings are suggestive of a small but potentially important reduction in cardiovascular risk in trials longer than two years. Lifestyle advice to all those at high risk of cardiovascular disease (especially where statins are unavailable or rationed), and to lower risk population groups, should continue to include permanent reduction of dietary saturated fat and partial replacement by unsaturates

Predictions for the Cosmogenic Neutrino Flux in Light of New Data from the Pierre Auger Observatory

The Pierre Auger Observatory (PAO) has measured the spectrum and composition of the ultrahigh energy cosmic rays with unprecedented precision. We use these measurements to constrain their spectrum and composition as injected from their sources and, in turn, use these results to estimate the spectrum of cosmogenic neutrinos generated in their propagation through intergalactic space. We find that the PAO measurements can be well fit if the injected cosmic rays consist entirely of nuclei with masses in the intermediate (C, N, O) to heavy (Fe, Si) range. A mixture of protons and heavier species is also acceptable but (on the basis of existing hadronic interaction models) injection of pure light nuclei (p, He) results in unacceptable fits to the new elongation rate data. The expected spectrum of cosmogenic neutrinos can vary considerably, depending on the precise spectrum and chemical composition injected from the cosmic ray sources. In the models where heavy nuclei dominate the cosmic ray spectrum and few dissociated protons exceed GZK energies, the cosmogenic neutrino flux can be suppressed by up to two orders of magnitude relative to the all-proton prediction, making its detection beyond the reach of current and planned neutrino telescopes. Other models consistent with the data, however, are proton-dominated with only a small (1-10%) admixture of heavy nuclei and predict an associated cosmogenic flux within the reach of upcoming experiments. Thus a detection or non-detection of cosmogenic neutrinos can assist in discriminating between these possibilities.Comment: 10 pages, 7 figure

Results from PAMELA, ATIC and FERMI : Pulsars or Dark Matter ?

It is well known that the dark matter dominates the dynamics of galaxies and clusters of galaxies. Its constituents remain a mystery despite an assiduous search for them over the past three decades. Recent results from the satellite-based PAMELA experiment detect an excess in the positron fraction at energies between 10-100 GeV in the secondary cosmic ray spectrum. Other experiments namely ATIC, HESS and FERMI show an excess in the total electron (\ps + \el) spectrum for energies greater 100 GeV. These excesses in the positron fraction as well as the electron spectrum could arise in local astrophysical processes like pulsars, or can be attributed to the annihilation of the dark matter particles. The second possibility gives clues to the possible candidates for the dark matter in galaxies and other astrophysical systems. In this article, we give a report of these exciting developments.Comment: 27 Pages, extensively revised and significantly extended, to appear in Pramana as topical revie

jClust: a clustering and visualization toolbox

jClust is a user-friendly application which provides access to a set of widely used clustering and clique finding algorithms. The toolbox allows a range of filtering procedures to be applied and is combined with an advanced implementation of the Medusa interactive visualization module. These implemented algorithms are k-Means, Affinity propagation, Bron–Kerbosch, MULIC, Restricted neighborhood search cluster algorithm, Markov clustering and Spectral clustering, while the supported filtering procedures are haircut, outside–inside, best neighbors and density control operations. The combination of a simple input file format, a set of clustering and filtering algorithms linked together with the visualization tool provides a powerful tool for data analysis and information extraction