The amazing spectrum of light – LASER

“In right light at right time everything is extraordinary”- says Aaron Rose. This is very true with respect to lasers. Discovery of lasers from the spectrum of light has revolutionized the technology in many fields. The word “LASER” means Light Amplification by Stimulated Emission of Radiation. They offer many useful clinical applications for general dentists in the diagnosis and treatment of patients. There are many clinical, aesthetic, and psychological reasons to use lasers. Herein we present a brief overview of “THE AMAZING SPECTRUM OF LIGHT

Bilateral stroke: unpaired anterior cerebral artery infarct rare presentation

ACA territory is an uncommon site for occlusive vascular strokes. Small degree of asymmetry of anterior arteries is present in 80% of patients. Common variants of anterior cerebral arteries include aplasia or hypoplasia of A1 segment. Hypoplasia is found in 10% and aplasia in 1-2% of postmortem examinations.  Of all ischemic strokes ACA territory strokes constitutes only 0.6 to 3%. Bilateral ischemic stroke in unpaired ACA is rare entity. We report a case of unpaired ACA due to hypoplasia of right ACA, presenting as stuttering hemiplegia with bilateral focal neurological deficit

Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

Upon exposure to environmental stress, phosphorylation of the α subunit of eIF2 (eIF2α-P) represses global protein synthesis, coincident with preferential translation of gene transcripts that mitigate stress damage or alternatively trigger apoptosis. Because there are multiple mammalian eIF2 kinases, each responding to different stress arrangements, this translational control scheme is referred to as the integrated stress response (ISR). Included among the preferentially translated mRNAs induced by eIF2α-P is that encoding the transcription factor CHOP (DDIT3/GADD153). Enhanced levels of CHOP promote cell death when ISR signaling is insufficient to restore cell homeostasis. Preferential translation of CHOP mRNA occurs by a mechanism involving ribosome bypass of an inhibitory upstream ORF (uORF) situated in the 5'-leader of the CHOP mRNA. In this study, we used biochemical and genetic approaches to define the inhibitory features of the CHOP uORF and the biological consequences of loss of the CHOP uORF on CHOP expression during stress. We discovered that specific sequences within the CHOP uORF serve to stall elongating ribosomes and prevent ribosome reinitiation at the downstream CHOP coding sequence. As a consequence, deletion of the CHOP uORF substantially increases the levels and modifies the pattern of induction of CHOP expression in the ISR. Enhanced CHOP expression leads to increased expression of key CHOP target genes, culminating in increased cell death in response to stress

Stock price prognosticator using machine learning techniques.

Stock market price prediction is one of the favourite research topics under consideration for professionals from various fields like mathematics, statistics, history, finance, computer science engineering etc., as it requires a set of skills to predict variation of price of shares in a very volatile and challenging share market scenario. Share market trading is mostly dependent on sentiments of investors and other factors like economic policies, political changes, natural disasters etc., Many theories were forwarded, mathematical and statistical applications in conjunction with probability, to simplify the complex process. After the advent of computers, it got further simplified but still challenging due to various external influential factors ruling the volatility of the market prices. Thus, AI and ML algorithms were being developed, but for only for next day using Linear Regression procedures.Our project aims to predict the prices of shares more precisely and accurately using special algorithms using RNN by improvising the back propagation, feedback routines to overcome the short-term memory loss involved in RNN thus providing efficiency in LSTM applications.Our project emphasizes how the LSTM applications perform with datasets of extreme, larger and minimal fluctuating data

Efficient Design and Deployment of Aqua Monitoring Systems Using WSNs and Correlation Analysis

The roots of innovation are extending towards every field to provide ace solution. We cater an ace solution for aquaculture, where their yields (shrimp, fish, etc.) depends on the ponds water characteristics. The parameters depending on water must kept at certain optimal levels for better cultivation of Aqua. The parameters of water extremely project alterations during the day and also alter depending upon the environmental conditions i.e., it is necessary to monitor these parameters with high frequency. We adopt wireless sensor networks to monitor aqua forms. This system consists of two modules, they are transmitter and receiver station. We navigate data to database at receiver station through the GSM. The graphical user interface was designed in such a manner that the observations are forwarded to the farmer as message in their respective local languages to their mobile phones. That alerts them in unhygienic environmental conditions for adopting suitable measures

Limonene and BEZ 235 inhibits growth of COLO-320 and HCT-116 colon cancer cells

D-Limonene is a dietary monoterpene with significant anticancer activity against many cancer types in preclinical and clinical studies. The study is designed to investigate synergistic anticancer effects of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells were treated with both the drugs alone and in combination and the effects on cell viability; cell migration and clonogenic potential were examined. Results show that both drugs exhibited dose and time dependant cytotoxicity on the cell lines tested. CompuSyn analysis of the drug combination effects revealed the strong synergistic interaction of the combination. Our results also indicate that COLO-320 cells were more sensitive for anticancer effects of the drugs than HCT-116 cells. The presence of Ras and PI3K mutations in HCT-116 cells could possibly be one of the main reasons for the observed outcome as compared to the wild type expressions of them in COLO-320 cells

Anti diabetic effect of ethanolic extract of leaves of Ocimum sanctum in alloxan induced diabetes in rats

Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia resulting from defects of reduced insulin secretion, decreased glucose utilization and increase in glucose production. It is estimated that there are currently 285 million people worldwide and this number is set to increase to 438 million by the year 2030. India has the highest number of patients with known diabetes worldwide, with a prevalence of 11.6%. The aim of the study was to evaluate the anti diabetic activity of ethanolic extract of leaves of plant Ocimum sanctum in alloxan induced diabetes in rats.Methods: The study was conducted on 4 groups of 6 rats each to evaluate the hypoglycaemic effect of ethanolic extract of Ocimum sanctum. Glibenclamide was used as a standard drug and the results were compared in reference to it. Tween 80 was given for both normal and diabetic control groups. The fasting blood sugar levels were recorded on 1st, 3rd, 5th, 7th, 10th days by glucometer.Results: The results indicate that the test compound ethanolic extract of Ocimum sanctum has significant and sustained oral hypoglycaemic activity, comparable with the hypoglycaemic effect of glibenclamide, a sulfonylurea.Conclusion: The hypoglycaemic potential of the test compound is found to be comparable with that of the standard drug glibenclamide

Whole Genome Sequencing and Comparative Genomic Analysis Reveal Allelic Variations Unique to a Purple Colored Rice Landrace (Oryza sativa ssp. indica cv. Purpleputtu)

Purpleputtu (Oryza sativa ssp. indica cv. Purpleputtu) is a unique rice landrace from southern India that exhibits predominantly purple color. This study reports the underlying genetic complexity of the trait, associated domestication and de-domestication processes during its coevolution with present day cultivars. Along-with genome level allelic variations in the entire gene repertoire associated with the purple, red coloration of grain and other plant parts. Comparative genomic analysis using ‘a panel of 108 rice lines’ revealed a total of 3,200,951 variants including 67,774 unique variations in Purpleputtu (PP) genome. Multiple sequence alignment uncovered a 14 bp deletion in Rc (Red colored, a transcription factor of bHLH class) locus of PP, a key regulatory gene of anthocyanin biosynthetic pathway. Interestingly, this deletion in Rc gene is a characteristic feature of the present-day white pericarped rice cultivars. Phylogenetic analysis of Rc locus revealed a distinct clade showing proximity to the progenitor species Oryza rufipogon and O. nivara. In addition, PP genome exhibits a well conserved 4.5 Mbp region on chromosome 5 that harbors several loci associated with domestication of rice. Further, PP showed 1,387 unique when SNPs compared to 3,023 lines of rice (SNP-Seek database). The results indicate that PP genome is rich in allelic diversity and can serve as an excellent resource for rice breeding for a variety of agronomically important traits such as disease resistance, enhanced nutritional values, stress tolerance, and protection from harmful UV-B rays