Best practice in police social media adaptation

Summary: Best Practice in Police Social Media Adaptation. This document describes best practice of European police forces in adapting social media. The description of these practices stems from a workshop series and other events where police ICT experts met with academics and industry experts; and from a study of the Twitter usage of British police forces during the 2011 riots. Grouped in nine categories, we describe different uses and implementation strategies of social media by police forces. Based on these examples, we show that there have been numerous ways in which police forces benefitted from adopting social media, ranging from improved information for investigations and an improved relationship with the public to a more efficient use of resources

Transfer of Parahydrogen Induced Polarization in Scalar Coupled Systems at Variable Magnetic Field

Para-Hydrogen Induced Polarization (PHIP) experiments were performed in coupled multispin systems at variable magnetic fields. We studied the magnetic field dependence of PHIP in styrene, which is the product of hydrogenation of phenylacetylene. At low magnetic fields where the spins are coupled strongly by scalar interaction efficient polarization transfer among the interacting protons takes place. The experimentally observed spectra are in good agreement with the simulation, which takes into account eight coupled spins. We also demonstrate effects of nuclear spin level anti-crossings on the PHIP pattern. It is shown that rapid passage through the level anti-crossing enables highly efficient polarization transfer between specific spin orders. In addition, we studied PHIP transfer to 13C and 19F hetero-nuclei. It is shown that hetero- nuclei can be efficiently polarized in a wide field range; in particular, for polarizing them it is not necessary to go to ultra-low fields, which provide their strong coupling to protons. The resulting polarization is of the multiplet type and gives strong enhancements of the individual NMR lines. In general, variation of the magnetic field gives the opportunity for manipulating PHIP patterns and transferring polarization to target spins of choice

Linking burst-only X-ray binary sources to faint X-ray transients

Burst-only sources are X-ray sources showing up only during short bursts but with no persistent emission (at least with the monitoring instrument which led to their discovery). These bursts have spectral characteristics consistent with thermonuclear (type I) burst from the neutron star surface, linking burst-only sources to neutron star X-ray binary transients. We have carried out a series of snapshot observations of the entire sample of burst-only sources with the Swift satellite. We found a few sources in outburst and detect faint candidates likely representing their quiescent counterparts. In addition, we observed three quasi-persistent faint X-ray binary transients. Finally we discuss burst-only sources and quasi-persistent sources in the framework of neutron star transients.Comment: 9 pages, 8 figures. Accepted for publication on Ap

General practitioners' prescribing behaviour as a determinant of poor persistence with inhaled corticosteroids in children with respiratory symptoms:Mixed methods study

OBJECTIVES: To evaluate general practitioners’ (GPs’) prescribing behaviour as a determinant of persistence with and adherence to inhaled corticosteroids (ICS) in children. DESIGN: Prospective observational study of persistence with and adherence to ICS followed by a focus group study of the GPs prescribing this treatment. SETTING: 7 primary care practices in the area of Zwolle, the Netherlands. PARTICIPANTS: 134 children aged 2–12 years had been prescribed ICS in the year before the study started by their 19 GPs. MAIN OUTCOME MEASURES: Patterns and motives of GPs’ prescribing behaviour and the relationship with persistence with and adherence to ICS. RESULTS: GPs’ prescribing behaviour was characterised by prescribing short courses of ICS to children with various respiratory symptoms without follow-up for making a diagnosis of asthma. This was driven by the GPs’ pragmatic approach to deal with the large number of children with respiratory symptoms, and by beliefs about ICS which differed from currently available evidence. This prescribing behaviour was the main reason why 68 (51%) children did not persist with the use of ICS. In children with persistent use of ICS and a GP's advice to use ICS on a daily basis, the median (IQR) adherence was 70% (41–84%), and was similar for patients with persistent asthma and children lacking a diagnosis or symptoms of asthma. CONCLUSIONS: Inappropriate prescription of ICS to children by GPs is common and drives the lack of persistence with ICS therapy in primary care. This finding should be taken into account when interpreting data from large prescription database studies. Improving primary healthcare providers’ knowledge and competence in diagnosing and managing asthma in children is needed

Sedimentation and Type I X-ray Bursts at Low Accretion Rates

Neutron stars, with their strong surface gravity, have interestingly short timescales for the sedimentation of heavy elements. Motivated by observations of Type I X-ray bursts from sources with extremely low persistent accretion luminosities, L_X < 10^{36}\usp\ergspersecond (\simeq 0.01\ensuremath{L_{\mathrm{Edd}}}), we study how sedimentation affects the distribution of isotopes and the ignition of H and He in the envelope of an accreting neutron star. For local mass accretion rates \mdot \lesssim 10^{-2}\medd (for which the ignition of H is unstable), where \medd = 8.8\times 10^{4}\nsp\gpscps, the helium and CNO elements sediment out of the accreted fuel before reaching a temperature where H would ignite. Using one-zone calculations of the thermonuclear burning, we find a range of accretion rates for which the unstable H ignition does not trigger unstable He burning. This range depends on the emergent flux from reactions in the deep neutron star crust; for F = 0.1\nsp\MeV(\dot{m}/\mb), the range is 3\times 10^{-3}\medd\lesssim\mdot\lesssim 10^{-2}\medd. We speculate that sources accreting in this range will build up a massive He layer that later produces an energetic and long X-ray burst. At mass accretion rates lower than this range, we find that the H flash leads to a strong mixed H/He flash. Surprisingly, even at accretion rates \mdot \gtrsim 0.1\medd, although the H and He do not completely segregate, the H abundance at the base of the accumulated layer is still reduced. While following the evolution of the X-ray burst is beyond the scope of this introductory paper, we note that the reduced proton-to-seed ratio favors the production of \iso{12}{C}--an important ingredient for subsequent superbursts.Comment: 15 pages, 14 figures, submitted to ApJ, revised versio

Expression of chicken hepatic type I and type III iodothyronine deiodinases during embryonic development

In embryonic chicken liver (ECL) two types of iodothyronine deiodinases are expressed: D1 and D3. D1 catalyzes the activation as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. D3 only catalyzes inner ring deiodination. D1 and D3 have been cloned from mammals and amphibians and shown to contain a selenocysteine (Sec) residue. We characterized chicken D1 and D3 complementary DNAs (cDNAs) and studied the expression of hepatic D1 and D3 messenger RNAs (mRNAs) during embryonic development. Oligonucleotides based on two amino acid sequences strongly conserved in the different deiodinases (NFGSCTSecP and YIEEAH) were used for reverse transcription-PCR of poly(A+) RNA isolated from embryonic day 17 (E17) chicken liver, resulting in the amplification of two 117-bp DNA fragments. Screening of an E17 chicken liver cDNA library with these probes led to the isolation of two cDNA clones, ECL1711 and ECL1715. The ECL1711 clone was 1360 bp long and lacked a translation start site. Sequence alignment showed that it shared highest sequence identity with D1s from other vertebrates and that the coding sequence probably lacked the first five nucleotides. An ATG start codon was engineered by site-directed mutagenesis, generating a mutant (ECL1711M) with four additional codons (coding for MGTR). The open reading frame of ECL1711M coded for a 249-amino acid protein showing 58-62% identity with mammalian D1s. An in-frame TGA codon was located at position 127, which is translated as Sec in the presence ofa Sec insertion sequence (SECIS) identified in the 3'-untranslated region. Enzyme activity expressed in COS-1 cells by transfection with ECL1711M showed the same catalytic, substrate, and inhibitor specificities as native chicken D1. The ECL1715 clone was 1366 bp long and also lacked a translation start site. Sequence alignment showed that it was most homologous with D3 from other species and that the coding sequence lacked approximately the first 46 nucleotides. The deduced amino acid sequence showed 62-72% identity with the D3 sequences from other species, including a putative Sec residue at a corresponding position. The 3'-untranslated region of ECL1715 also contained a SECIS element. These results indicate that ECL1711 and ECL1715 are near-full-length cDNA clones for chicken D1 and D3 selenoproteins, respectively. The ontogeny of D1 and D3 expression in chicken liver was studied between E14 and 1 day after hatching (C1). D1 activity showed a gradual increase from E14 until C1, whereas D1 mRNA level remained relatively constant. D3 activity and mRNA level were highly significantly correlated, showing an increase from E14 to E17 and a strong decrease thereafter. These results suggest that the regulation of chicken hepatic D3 expression during embryonic development occurs predominantly at the pretranslational level

Actual persuasiveness : Impact of personality, age and gender on message type susceptibility

The authors would like to acknowledge and thank all the volunteers who participated in the experiment and provided helpful comments. The first author is funded by an EPSRC doctoral training grant.Postprin