Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.

This is the final version. Available from Nature Research via the DOI in this record. Data availability: All data that support the findings of this study are available upon reasonable request from the corresponding author.Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.Wellcome TrustWellcome TrustCroatian Science Foundatio