Generalized Mittag-Leffler Distributions and Processes for Applications in Astrophysics and Time Series Modeling

Geometric generalized Mittag-Leffler distributions having the Laplace transform $\frac{1}{1+\beta\log(1+t^\alpha)},00$ is introduced and its properties are discussed. Autoregressive processes with Mittag-Leffler and geometric generalized Mittag-Leffler marginal distributions are developed. Haubold and Mathai (2000) derived a closed form representation of the fractional kinetic equation and thermonuclear function in terms of Mittag-Leffler function. Saxena et al (2002, 2004a,b) extended the result and derived the solutions of a number of fractional kinetic equations in terms of generalized Mittag-Leffler functions. These results are useful in explaining various fundamental laws of physics. Here we develop first-order autoregressive time series models and the properties are explored. The results have applications in various areas like astrophysics, space sciences, meteorology, financial modeling and reliability modeling.Comment: 12 pages, LaTe

The risk of telling : a dyadic perspective on romantic partners' responses to child sexual abuse disclosure and their associations with sexual and relationship satisfaction

Essai présenté à la Faculté des arts et des sciences en vue de l'obtention du grade de Doctorat en psychologie clinique (D. Psy.)Les survivants d’agression sexuelle à l’enfance (ASE) doivent souvent composer avec les conséquences à long terme de ce trauma. Toutefois, il existe une grande variabilité quant aux impacts individuels de l’ASE. Certains auteurs croient que la réponse obtenue lors du dévoilement de l’ASE aux proches du survivant, pourrait être l’un des déterminants de cette variabilité. Cependant, le dévoilement à l’âge adulte, notamment au partenaire amoureux, a été peu étudié. La présente étude examine les associations entre les réponses des partenaires amoureux au dévoilement, tels que perçues par les survivants, ainsi que la satisfaction sexuelle et conjugale des deux membres du couple, auprès d’un échantillon de 70 couples de la communauté ayant rapporté une ASE et l’ayant dévoilée à leur partenaire. Les participants ont complété des questionnaires auto-rapportés en ligne. Les résultats d’analyses de trajectoire au sein d’un modèle « Actor-Partner Interdependence Model » (APIM) indiquent que les réponses de « soutien émotionnel » de la part des partenaires durant le dévoilement, telles que perçues par les survivants, étaient positivement associées à leur propre satisfaction sexuelle ainsi qu’à celle de leur partenaire. Les réponses de « stigmatisation/se sentir traité différemment » de la part des partenaires, telles que perçues par les survivants, étaient associées à une moins bonne satisfaction conjugale, à la fois pour les survivants et leurs partenaires. Les résultats suggèrent que les réponses des partenaires au dévoilement d’une ASE, tels que perçues par les survivants, peuvent avoir un impact positif autant que négatif sur la satisfaction conjugale et sexuelle des deux partenaires.Survivors of childhood sexual abuse (CSA) often experience adverse trauma-related long term consequences, which vary widely among survivors. Some authors argued that this variability might be explained in part by the response of others to survivors’ disclosure of the CSA. However, disclosure during adulthood has received little empirical attention, in particular, disclosure to a romantic partner. Among 70 community couples who reported CSA and disclosure to their partner, this study examined associations between survivors’ perception of partner responses to their disclosure, and both partners’ sexual and relationship satisfaction. Participants completed self-report questionnaires online. Results of path analyses within an actor-partner interdependence model indicated that survivors’ perceived partner responses of emotional support to disclosure were associated with their own and their partners' higher sexual satisfaction. Survivors’ perceived responses of being stigmatized/treated differently by the partner were associated with their own and their partners’ poorer relationship satisfaction. Findings suggest that survivor-perceived partner responses to the disclosure of CSA can have both a positive and a negative impact on the sexual and relationship satisfaction of both partners

Two randomised phase II trials of subcutaneous interleukin-2 and histamine dihydrochloride in patients with metastatic renal cell carcinoma

Histamine inhibits formation and release of phagocyte-derived reactive oxygen species, and thereby protects natural killer and T cells against oxidative damage. Thus, the addition of histamine may potentially improve the efficacy of interleukin-2 (IL-2). Two randomised phase II trials of IL-2 with or without histamine dihydrochloride (HDC) in patients with metastatic renal cell carcinoma (mRCC) were run in parallel. A total of 41 patients were included in Manchester, UK and 63 in Aarhus, Denmark. The self-administered, outpatient regimen included IL-2 as a fixed dose, 18 MIU s.c. once daily, 5 days per week for 3 weeks followed by 2 weeks rest. Histamine dihydrochloride was added twice daily, 1.0 mg s.c., concomitantly with IL-2. A maximum of four cycles were given. The Danish study showed a statistically significant 1-year survival benefit (76 vs 47%, P=0.03), a trend towards benefit in both median survival (18.3 vs 11.4 months, P=0.07), time to PD (4.5 vs 2.2 months, P=0.13) and clinical benefit (CR+PR+SD) (58 vs 37%, P=0.10) in favour of IL-2/HDC, whereas the UK study was negative for all end points. Only three patients had grade 4 toxicity; however, two were fatal. A randomised phase III trial is warranted to clarify the potential role of adding histamine to IL-2 in mRCC

The effectiveness of public health interventions to reduce the health impact of climate change:a systematic review of systematic reviews

Climate change is likely to be one of the most important threats to public health in the coming years. Yet despite the large number of papers considering the health impact of climate change, few have considered what public health interventions may be of most value in reducing the disease burden. We aimed to evaluate the effectiveness of public health interventions to reduce the disease burden of high priority climate sensitive diseases

Thermodynamic analysis of the Quantum Critical behavior of Ce-lattice compounds

A systematic analysis of low temperature magnetic phase diagrams of Ce compounds is performed in order to recognize the thermodynamic conditions to be fulfilled by those systems to reach a quantum critical regime and, alternatively, to identify other kinds of low temperature behaviors. Based on specific heat ($C_m$) and entropy ($S_m$) results, three different types of phase diagrams are recognized: i) with the entropy involved into the ordered phase ($S_{MO}$) decreasing proportionally to the ordering temperature ($T_{MO}$), ii) those showing a transference of degrees of freedom from the ordered phase to a non-magnetic component, with their $C_m(T_{MO})$ jump ($\Delta C_m$) vanishing at finite temperature, and iii) those ending in a critical point at finite temperature because their $\Delta C_m$ do not decrease with $T_{MO}$ producing an entropy accumulation at low temperature. Only those systems belonging to the first case, i.e. with $S_{MO}\to 0$ as $T_{MO}\to 0$, can be regarded as candidates for quantum critical behavior. Their magnetic phase boundaries deviate from the classical negative curvature below $T\approx 2.5$\,K, denouncing frequent misleading extrapolations down to T=0. Different characteristic concentrations are recognized and analyzed for Ce-ligand alloyed systems. Particularly, a pre-critical region is identified, where the nature of the magnetic transition undergoes significant modifications, with its $\partial C_m/\partial T$ discontinuity strongly affected by magnetic field and showing an increasing remnant entropy at $T\to 0$. Physical constraints arising from the third law at $T\to 0$ are discussed and recognized from experimental results

Nutritional, Health, and Technological Functionality of Lupin Flour Addition to Bread and Other Baked Products: Benefits and Challenges

Lupin is an undervalued legume despite its high protein and dietary fiber content and potential health benefits. This review focuses on the nutritional value, health benefits, and technological effects of incorporating lupin flour into wheat-based bread. Results of clinical studies suggest that consuming lupin compared to wheat bread and other baked products reduce chronic disease risk markers; possibly due to increased protein and dietary fiber and bioactive compounds. However, lupin protein allergy has also been recorded. Bread quality has been improved when 10% lupin flour is substituted for refined wheat flour; possibly due to lupin-wheat protein cross-linking assisting bread volume and the high water-binding capacity (WBC) of lupin fiber delaying staling. Above 10% substitution appears to reduce bread quality due to lupin proteins low elasticity and the high WBC of its dietary fiber interrupting gluten network development. Gaps in understanding of the role of lupin flour in bread quality include the optimal formulation and processing conditions to maximize lupin incorporation, role of protein cross-linking, antistaling functionality, and bioactivity of its γ-conglutin protein

Obesity and the Rate of Time Preference: Is there a Connection?

We hypothesize that recent trends in U.S. and worldwide obesity are, in part, related to an increase in the marginal rate of time preference, where time preference refers to the rate at which people are willing to trade current benefit for future benefit. The higher the rate of time preference, the larger is the factor by which individuals discount the future health risks associated with current consumption. Data from the United States, as well as international evidence, suggests that a relationship between these two variables is plausible. We encourage researchers to explore the possible link between obesity and time preference, as important insights are likely to result