MicroRNAs in B cell development and malignancy

MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and is also critical at the level of specific miRNAs. In this review, we discuss miRNAs that are involved in normal B cell development in the bone marrow and during B cell activation and terminal differentiation in the periphery. Next, we turn to miRNAs that are dysregulated during diseases of B cells, including malignant diseases and autoimmunity. Further study of miRNAs and their targets will lead to a better understanding of B cell development, and should also lead to the development of novel therapeutic strategies against B cell diseases

Detection of a Series of X-ray Dips Associated with a Radio Flare in GRS 1915+105

We report the detection of a series of X-ray dips in the Galactic black hole candidate GRS 1915+105 during 1999 June 6-17 from observations carried out with the Pointed Proportional Counters of the Indian X-ray Astronomy Experiment on board the Indian satellite IRS-P3. The observations were made after the source made a transition from a steady low-hard state to a chaotic state which occuered within a few hours. Dips of about 20-160 seconds duration are observed on most of the days. The X-ray emission outside the dips shows a QPO at ~ 4 Hz which has characteristics similar to the ubiquitous 0.5 - 10 Hz QPO seen during the low-hard state of the source. During the onset of dips this QPO is absent and also the energy spectrum is soft and the variability is low compared to the non-dip periods. These features gradually re-appear as the dip recovers. The onset of the occurrence of a large number of such dips followed the start of a huge radio flare of strength 0.48 Jy (at 2.25 GHz). We interpret these dips as the cause for mass ejection due to the evacuation of matter from an accretion disk around the black hole. We propose that a super-position of a large number of such dip events produces a huge radio jet in GRS 1915+105.Comment: 18 pages, 7 figures, Accepted for publication in Ap

Information geometry of density matrices and state estimation

Given a pure state vector |x> and a density matrix rho, the function p(x|rho)= defines a probability density on the space of pure states parameterised by density matrices. The associated Fisher-Rao information measure is used to define a unitary invariant Riemannian metric on the space of density matrices. An alternative derivation of the metric, based on square-root density matrices and trace norms, is provided. This is applied to the problem of quantum-state estimation. In the simplest case of unitary parameter estimation, new higher-order corrections to the uncertainty relations, applicable to general mixed states, are derived.Comment: published versio

On the origin of the various types of radio emission in GRS 1915+105

We investigate the association between the radio ``plateau'' states and the large superluminal flares in GRS 1915+105 and propose a qualitative scenario to explain this association. We identify several candidate superluminal flare events from available monitoring data on this source and analyze the contemporaneous RXTE pointed observations. We detect a strong correlation between the average X-ray flux during the ``plateau'' state and the total energy emitted in radio during the subsequent radio flare. We find that the sequence of events is similar for all large radio flares with a fast rise and exponential decay morphology. Based on these results, we propose a qualitative scenario in which the separating ejecta during the superluminal flares are observed due to the interaction of the matter blob ejected during the X-ray soft dips, with the steady jet already established during the ``plateau'' state. This picture can explain all types of radio emission observed from this source in terms of its X-ray emission characteristics.Comment: Corrected typo in the author names, contents unchanged, accepted in Ap

Field Theories of Frustrated Heisenberg Antiferromagnets

We study the Heisenberg antiferromagnetic chain with both dimerization and frustration. The classical ground state has three phases: a Neel phase, a spiral phase and a colinear phase. In each phase, we discuss a non-linear sigma model field theory governing the low energy excitations. We study the theory in the spiral phase in detail using the renormalization group. The field theory, based on an $SO(3)$ matrix-valued field, becomes $SO(3) \times SO(3)$ and Lorentz invariant at long distances where the elementary excitation is analytically known to be a massive spin-$1/2$ doublet. The field theory supports $Z_2 ~$ solitons which lead to a double degeneracy in the spectrum for half-integer spins (when there is no dimerization).Comment: Latex, 12 pages, 2 figures (gzipped and uuencoded

Different types of X-ray bursts from GRS 1915+105 and their origin

We report the X-ray observations of the Galactic X-ray transient source GRS 1915+105 with the PPCs of the Indian X-ray Astronomy Experiment(IXAE) onboard the Indian satellite IRS-P3 during 1997 June - August, which have revealed the presence of four types of intense X-ray bursts. All the observed bursts have a slow exponential rise, a sharp linear decay, and they can broadly be put in two classes: irregular and quasi-regular bursts in one class, and regular bursts in another class. The regular bursts are found to have two distinct time scales and they persist over extended durations. There is a strong correlation between the preceding quiescent time and the burst duration for the quasi-regular and irregular bursts. No such correlation is found for the regular bursts. The ratio of average flux during the burst time to the average flux during the quiescent phase is high and variable for the quasi- regular and irregular bursts while it is low and constant for the regular bursts. We suggest that the peculiar bursts that we have seen are charact- eristic of the change of state of the source. The source can switch back and forth between the low-hard state and the high-soft state near critical accretion rates in a very short time scale. A test of the model is presented using the publicly available 13-60 keV RXTE/PCA data for irregular and regular bursts concurrent with our observations.Comment: 13 pages, 12 figures, Accepted in APJ, emulateapj style use

Connection between accretion disk and superluminal radio jets and the role of radio plateau state in GRS 1915+105

We investigate the association between the accretion disk during radio plateau state and the following superluminal relativistic radio jets with peak intensity varies from 200 mJy to 1000 mJy observed over a period of five years and present the evidences of direct accretion disc-jet connection in microquasar GRS 1915+105. We have analysed RXTE PCA/HEXTE X-ray data and have found that the accretion rate, $\dot{m}_{accr}$, as inferred from the X-ray flux, is very high during the radio plateaux. We suggest that the accretion disk during the radio plateaux always associated with radiation-driven wind which is manifested in the form of enhanced absorption column density for X-ray and the depleted IR emission. We find that the wind density increases with the accretion disk luminosity during the radio plateaux. The wind density is similar to the density of the warm absorber proposed in extragalactic AGNs and Quasars. We suggest a simple model for the origin of superluminal relativistic jets. Finally, We discuss the implications of this work for galactic microquasars and the extragalactic AGNs and Quasars.Comment: 9 pages, 6 Figures, Accepted for publication in Ap

Fast Transition between High-soft and Low-soft States in GRS 1915+105: Evidence for a Critically Viscous Accretion Flow

We present the results of a detailed analysis of RXTE observations of class $\omega$ which show an unusual state transition between high-soft and low-soft states in the microquasar GRS 1915+105. Out of about 600 pointed RXTE observations, the source was found to exhibit such state transition only on 16 occasions. An examination of the RXTE/ASM data in conjunction with the pointed observations reveals that these events appeared as a series of quasi-regular dips in two stretches of long duration (about 20 days during each occasions) when hard X-ray and radio flux were very low. The X-ray light curve and color-color diagram of the source during these observations are found to be different from any reported so far. The duration of these dips is found to be of the order of a few tens of seconds with a repetition time of a few hundred seconds. The transition between these dips and non-dips which differ in intensity by a factor of ~ 3.5, is observed to be very fast (~ a few seconds). It is observed that the low-frequency narrow QPOs are absent in the power density spectrum (PDS) of the dip and non-dip regions of class $\omega$ and the PDS is a power law in 0.1 - 10 Hz frequency range. There is a remarkable similarity in the spectral and timing properties of the source during the dip and non-dip regions in these set of observations. These properties of the source are distinctly different from those seen in the observations of other classes. This indicates that the basic accretion disk structure during both dip and non-dip regions of class $\omega$ is similar, but differ only in intensity. To explain these observations, we invoke a model in which the viscosity is very close to critical viscosity and the shock wave is weak or absent.Comment: Replaced with correct figures, Jour. of Astrophysics and Astronomy (accepted

A dynamics-driven approach to precision machines design for micro-manufacturing and its implementation perspectives

Precision machines are essential elements in fabricating high quality micro products or micro features and directly affect the machining accuracy, repeatability and efficiency. There are a number of literatures on the design of industrial machine elements and a couple of precision machines commercially available. However, few researchers have systematically addressed the design of precision machines from the dynamics point of view. In this paper, the design issues of precision machines are presented with particular emphasis on the dynamics aspects as the major factors affecting the performance of the precision machines and machining processes. This paper begins with a brief review of the design principles of precision machines with emphasis on machining dynamics. Then design processes of precision machines are discussed, and followed by a practical modelling and simulation approaches. Two case studies are provided including the design and analysis of a fast tool servo system and a 5-axis bench-top micro-milling machine respectively. The design and analysis used in the two case studies are formulated based on the design methodology and guidelines