63 research outputs found

    Two-dimensional multisolitons and azimuthons in Bose-Einstein condensates with attraction

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    We present spatially localized nonrotating and rotating (azimuthon) multisolitons in the two-dimensional (2D) ("pancake-shaped configuration") Bose-Einstein condensate (BEC) with attractive interaction. By means of a linear stability analysis, we investigate the stability of these structures and show that rotating dipole solitons are stable provided that the number of atoms is small enough. The results were confirmed by direct numerical simulations of the 2D Gross-Pitaevskii equation.Comment: 4 pages, 4 figure

    Polarons as stable solitary wave solutions to the Dirac-Coulomb system

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    We consider solitary wave solutions to the Dirac--Coulomb system both from physical and mathematical points of view. Fermions interacting with gravity in the Newtonian limit are described by the model of Dirac fermions with the Coulomb attraction. This model also appears in certain condensed matter systems with emergent Dirac fermions interacting via optical phonons. In this model, the classical soliton solutions of equations of motion describe the physical objects that may be called polarons, in analogy to the solutions of the Choquard equation. We develop analytical methods for the Dirac--Coulomb system, showing that the no-node gap solitons for sufficiently small values of charge are linearly (spectrally) stable.Comment: Latex, 26 page

    Markers of oxidative damage lipids and DNA in men with type 1 diabetes mellitus and different levels of albuminuria

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    BACKGROUND:Β Diabetic nephropathy is a specific kidney damage that affects up to 40% of type 1 diabetes mellitus patients. There is still insufficient knowledge about oxidative stress at the different levels of albuminuria.AIM:Β To assess the indicators of oxidative damage to lipids, DNA and antioxidant defense in men with type 1 diabetes mellitus and albuminuria different levels.MATERIALS AND METHODS:Β The study was conducted during 2018–2019. The main group included 56 men of reproductive age with type 1 diabetes mellitus (T1DM) divided into 2 groups: 24 patients with albuminuria level A1 (group A1) and 32Β patients with albuminuria level A2 (group A2). The control group consisted of 28 healthy men. The oxidative stress indicators content, as well as the activity of antioxidant defense system various links was evaluated. Spectrophotometric, fluorimetric and enzyme immunoassay methods were used.RESULTS:Β In patients of the A1 group there were higher values of the median of primary β€” conjugated dienes, secondaryΒ β€” ketodienes and conjugated trienes, final β€” Schiff bases products and 8-hydroxy-2’-deoxyguanosine in comparison with theΒ control. Similar changes in patients of the A2 group were found. Intergroup differences related to increased median values of TBARs and 8-hydroxy-2’-deoxyguanosine in patients of the A2 group compared with A1 group. The activity of theΒ antioxidant defense system in A1 group relative to the control by increased values of the glutathione peroxidase, reduced glutathione, oxidized glutathione median, and retinol was characterized. A2 group had higher values of glutathione peroxidase, reduced glutathione and oxidized glutathione medians in comparison with controls. Correlation analysis in A1 group showed theΒ relationships between the duration of the disease and the products of lipid peroxidation, glycated hemoglobin with 8-hydroxy-2’-deoxyguanosine. In A2 group, there was a relationship between the albumin/creatinine ratio and the duration of the disease, glomerular filtration rate and creatinine level.CONCLUSION:Β In men with T1DM, regardless of the albuminuria level, there are higher values of the oxidative damage lipids and DNA parameters, as well as the presence of close relationships between these parameters and the duration of theΒ disease, which can be used to develop potential strategies for the prevention and early therapy of diabetic nephropathy

    Efficiency of multidisciplinary rehabilitation of patients with breast cancer

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    The purpose of the study is evaluating the effectiveness of an interdisciplinary integrated approach in the rehabilitation of patients with breast cancer.ЦСль исслСдования – ΠΎΡ†Π΅Π½ΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ мСТдисциплинарного комплСксного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° Π² Ρ€Π΅Π°Π±ΠΈΠ»ΠΈΡ‚Π°Ρ†ΠΈΠΈ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹

    ΠœΠ°Ρ€ΠΊΠ΅Ρ€Ρ‹ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠ³ΠΎ поврСТдСния, Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ стрСсса Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с сахарным Π΄ΠΈΠ°Π±Π΅Ρ‚ΠΎΠΌ I Ρ‚ΠΈΠΏΠ° ΠΈ Ρ€Π°Π·Π½Ρ‹ΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½ΡƒΡ€ΠΈΠΈ

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    The aim of this work was to study the levels of podocalyxin and Ξ²-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods. 56 men of reproductive age with T1DM were divided into two groups: 24 patients with stage A1 albuminuria (group A1) and 32 patients with stage A2 albuminuria (group A2). The control group consisted of 28 healthy men. The levels of renal function markers, lipid metabolism parameters, and methylglyoxal were assessed using enzyme immunoassay and spectrophotometric and fluorometric methods.Results. Higher values for total cholesterol, triacylglycerol, and very-low-density lipoprotein medians in both groups A1 and A2 were found. In these groups, increased podocalyxin and methylglyoxal medians were revealed. Correlation analysis in the group A1 showed the presence of a relationship between the glomerular filtration rate (GFR) and creatinine. In the group A2, correlations between the generally accepted parameters of kidney injury (the albumin / creatinine ratio and GFR) and the duration of the disease and between GFR and the creatinine and methylglyoxal levels in the blood were identified. The podocalyxin level in this group correlated with the Ξ²2- microglobulin and methylglyoxal levels and lipid metabolism parameters. The level of Ξ²2-microglobulin correlated with the lipid metabolism parameters.Conclusion. Regardless of the level of albuminuria, men with T1DM had significantly increased levels of podocalyxin, lipid metabolism parameters, and methylglyoxal, as well as strong relationships between these parameters. The data of this study can be used for development of potential strategies for prevention and early treatment of diabetic nephropathy.ЦСль – ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ уровня подокаликсина, Ξ²-2-ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Π°, ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ стрСсса Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с сахарным Π΄ΠΈΠ°Π±Π΅Ρ‚ΠΎΠΌ (Π‘Π”) I Ρ‚ΠΈΠΏΠ° ΠΈ Ρ€Π°Π·Π½Ρ‹ΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½ΡƒΡ€ΠΈΠΈ.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ обслСдованиС 56 ΠΌΡƒΠΆΡ‡ΠΈΠ½ Ρ€Π΅ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ возраста с Π‘Π” I Ρ‚ΠΈΠΏΠ°, Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Π½Ρ‹Ρ… Π½Π° Π΄Π²Π΅ Π³Ρ€ΡƒΠΏΠΏΡ‹: 24 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° с Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½ΡƒΡ€ΠΈΠ΅ΠΉ стадии А1 (Π³Ρ€ΡƒΠΏΠΏΠ° А1) ΠΈ 32 – с Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½ΡƒΡ€ΠΈΠ΅ΠΉ стадии А2 (Π³Ρ€ΡƒΠΏΠΏΠ° А2). ΠšΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΡƒΡŽ Π³Ρ€ΡƒΠΏΠΏΡƒ составили 28 Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… ΠΌΡƒΠΆΡ‡ΠΈΠ½. ΠžΡ†Π΅Π½ΠΈΠ²Π°Π»ΡΡ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ ΠΏΠΎΡ‡Π΅Ρ‡Π½Ρ‹Ρ… ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ², ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠ² Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ мСтилглиоксаля (ΠœΠ“) с использованиСм ΠΈΠΌΠΌΡƒΠ½ΠΎΡ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π½Ρ‹Ρ…, спСктрофотомСтричСских ΠΈ Ρ„Π»ΡŽΠΎΡ€ΠΎΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ².Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. УстановлСны Π±ΠΎΠ»Π΅Π΅ высокиС значСния ΠΌΠ΅Π΄ΠΈΠ°Π½ ΠΎΠ±Ρ‰Π΅Π³ΠΎ холСстСрина, Ρ‚Ρ€ΠΈΠ°Ρ†ΠΈΠ»Π³Π»ΠΈΡ†Π΅Ρ€ΠΈΠ΄ΠΎΠ² ΠΈ Π»ΠΈΠΏΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ΄ΠΎΠ² ΠΎΡ‡Π΅Π½ΡŒ Π½ΠΈΠ·ΠΊΠΎΠΉ плотности Π² ΠΎΠ±Π΅ΠΈΡ… Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… с Π‘Π” I Ρ‚ΠΈΠΏΠ°. Π’ Π΄Π°Π½Π½Ρ‹Ρ… Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΈΡΡŒ Ρ‚Π°ΠΊΠΆΠ΅ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π½Ρ‹Π΅ значСния ΠΌΠ΅Π΄ΠΈΠ°Π½Ρ‹ подокаликсина ΠΈ основного показатСля ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ стрСсса – ΠœΠ“. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹ΠΉ коррСляционный Π°Π½Π°Π»ΠΈΠ· Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ А1 ΠΏΠΎΠΊΠ°Π·Π°Π» Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ зависимости уровня скорости ΠΊΠ»ΡƒΠ±ΠΎΡ‡ΠΊΠΎΠ²ΠΎΠΉ Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠΈ (БКЀ) ΠΈ ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π°. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ А2 ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΈΡΡŒ связи общСпринятых ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠ³ΠΎ поврСТдСния (ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½/ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½ ΠΈ БКЀ) с Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒΡŽ заболСвания, показатСля БКЀ с ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ ΠΊΡ€Π΅Π°Ρ‚ΠΈΠ½ΠΈΠ½Π° ΠΈ ΠœΠ“. Π£Ρ€ΠΎΠ²Π΅Π½ΡŒ подокаликсина Π² Π΄Π°Π½Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΊΠΎΡ€Ρ€Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π» с ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Ξ²2-ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Π°, ΠœΠ“, ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°; Ξ²2-ΠΌΠΈΠΊΡ€ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½ ΠΈΠΌΠ΅Π» взаимосвязи с ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Π°ΠΌΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π£ ΠΌΡƒΠΆΡ‡ΠΈΠ½ с Π‘Π” I Ρ‚ΠΈΠΏΠ° Π²Π½Π΅ зависимости ΠΎΡ‚ уровня Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½ΡƒΡ€ΠΈΠΈ ΠΎΡ‚ΠΌΠ΅Ρ‡Π°ΡŽΡ‚ΡΡ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ высокий ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ подокаликсина, ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½Π½Ρ‹Π΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ ΠœΠ“, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ тСсных взаимосвязСй ΠΌΠ΅ΠΆΠ΄Ρƒ этими ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Π°ΠΌΠΈ, Ρ‡Ρ‚ΠΎ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ использовано для Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… стратСгий ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ ΠΈ Ρ€Π°Π½Π½Π΅ΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ диабСтичСской Π½Π΅Ρ„Ρ€ΠΎΠΏΠ°Ρ‚ΠΈΠΈ

    Social spatial processes in the systems of settlement of the Belgorod region under the conditions of globalization = ΠŸΡ€ΠΎΡΡ‚Ρ€Π°Π½ΡΡ‚Π²Π΅Π½Π½Ρ‹Π΅ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ процСссы Π² систСмах рассСлСния БСлгородской области Π² условиях Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ

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    Π˜ΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ Ρ€Π°Π±ΠΎΡ‚ российских ΠΈ Π·Π°Ρ€ΡƒΠ±Π΅ΠΆΠ½Ρ‹Ρ… ΡƒΡ‡Π΅Π½Ρ‹Ρ…, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π°Π²Ρ‚ΠΎΡ€ΠΎΠ² ΡΡ‚Π°Ρ‚ΡŒΠΈ ΠΏΠΎ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΡŽ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-пространствСнной трансформации БСлгородской области, Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ экспСдиционных обслСдований Ρ€Π°ΠΉΠΎΠ½ΠΎΠ² области Π² 2012–2015 Π³Π³., ΠΎΡ„ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ статистичСскиС Π΄Π°Π½Π½Ρ‹Π΅ ΠΏΠΎ области ΠΈ Π΅Π΅ ΠΌΡƒΠ½ΠΈΡ†ΠΈΠΏΠ°Π»ΡŒΠ½Ρ‹ΠΌ образования

    Social spatial processes in the systems of settlement of the Belgorod region under the conditions of globalization = ΠŸΡ€ΠΎΡΡ‚Ρ€Π°Π½ΡΡ‚Π²Π΅Π½Π½Ρ‹Π΅ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ процСссы Π² систСмах рассСлСния БСлгородской области Π² условиях Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ

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    Π˜ΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ Ρ€Π°Π±ΠΎΡ‚ российских ΠΈ Π·Π°Ρ€ΡƒΠ±Π΅ΠΆΠ½Ρ‹Ρ… ΡƒΡ‡Π΅Π½Ρ‹Ρ…, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π°Π²Ρ‚ΠΎΡ€ΠΎΠ² ΡΡ‚Π°Ρ‚ΡŒΠΈ ΠΏΠΎ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΡŽ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-пространствСнной трансформации БСлгородской области, Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ экспСдиционных обслСдований Ρ€Π°ΠΉΠΎΠ½ΠΎΠ² области Π² 2012–2015 Π³Π³., ΠΎΡ„ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ статистичСскиС Π΄Π°Π½Π½Ρ‹Π΅ ΠΏΠΎ области ΠΈ Π΅Π΅ ΠΌΡƒΠ½ΠΈΡ†ΠΈΠΏΠ°Π»ΡŒΠ½Ρ‹ΠΌ образования
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