Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

Non peer reviewe

Geostatistical Analysis of NDVI in rotational and continuous grazing pastures

Livestock rearing is an important economical activity in Brazil, and its production is affected by pasture management methods. In this context, the use of geostatistics to analyze the spatial variability of the pastures? vegetation indices is valuable for understanding how management methods influence livestock production. Geostatistics is a tool that considers spatial dependency to interpolate data with no tendency and with minimum variance, which enables the production of precise maps using interpolated values at places that were not sampled (Vieira, 2000). The spatialization of vegetation indices such as the Normalized Difference Vegetation Index (NDVI) helps to evaluate the quality of pastures and to identify areas which may undergo a degradation process. In this study we intended to spatially evaluate two pasture management methods, rotational grazing and continuous grazing, using geostatistics and the NDVI as an indicator obtained from Landsat images of an area located in Pirassununga, São Paulo, Brazil, taken in 2011

Bonn Potential and Shell-Model Calculations for 206,205,204Pb

The structure of the nuclei 206,205,204Pb is studied interms of shell model employing a realistic effective interaction derived from the Bonn A nucleon-nucleon potential. The energy spectra, binding energies and electromagnetic properties are calculated and compared with experiment. A very good overall agreement is obtained. This evidences the reliability of our realistic effective interaction and encourages use of modern realistic potentials in shell-model calculations for heavy-mass nuclei.Comment: 4 pages, 4 figures, submitted to Physical Review

Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons

The ability of CNS stimulants to block the discriminative effects of pentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently produced greater than 90% pentobarbital-appropriate responding. The concomitant administration of pentobarbital and increasing doses of bemegride or pentylenetetrazol resulted in a dose-related decrease in pentobarbital-appropriate responses. In contrast, picrotoxin, another CNS stimulant, had little or no effect on pentobarbital-appropriate responding produced by pentobarbital.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46426/1/213_2004_Article_BF00432447.pd

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation. We formulate a multi-dimensional model of T-PLL pathogenesis centered around a unique combination of TCL1 overexpression with damaging ATM aberrations as initiating core lesions. The effects imposed by TCL1 cooperate with compromised ATM toward a leukemogenic phenotype of impaired DNA damage processing. Dysfunctional ATM appears inefficient in alleviating elevated redox burdens and telomere attrition and in evoking a p53-dependent apoptotic response to genotoxic insults. As non-genotoxic strategies, synergistic combinations of p53 reactivators and deacetylase inhibitors reinstate such cell death execution.Peer reviewe

Ruminal methane emissions in grazing beef heifers.

Brazil is one of the largest beef exporter in the world, and this is due to the introduction of Nellore cattle which has been adapted to the edaphoclimatic conditions of the country. With more than 200 million head, distributed in different production managements, producing through mainly extensive grazing system, Brazil has the responsibility to increase its productivity. That means, to produce more in smaller areas using fewer animals. One option to achieve that goal is to make the rotational management, thus, it may provide a better control of food supply for animals. However, it is also necessary to be concerned about the environment, especially for the methane produced from enteric fermentation in rumen. The objective of this study was to measure the emission of enteric methane in beef heifers in rotational and continuous grazing systems

Cold Dark Matter in SUSY Theories. The Role of Nuclear Form Factors and the Folding with the LSP Velocity

The momentum transfer dependence of the total cross section for elastic scattering of cold dark matter candidates, i.e. lightest supersymmetric particle (LSP), with nuclei is examined. The presented calculations of the event rates refer to a number of representative nuclear targets throughout the periodic table and have been obtained in a relatively wide phenomenologically allowed SUSY parameter space. For the coherent cross sections it is shown that, since the momentum transfer can be quite big for large mass of the LSP and heavy nuclei even though the energy transfer is small ($\le 100 KeV$), the total cross section can in such instances be reduced by a factor of about five. For the spin induced cross section of odd-A nuclear targets, as is the case of $^{207}Pb$ studied in this work, we found that the reduction is less pronounced, since the high multipoles tend to enhance the cross section as the momentum transfer increases (for LSP $mass < 200 GeV$) and partially cancell the momentum retardation. The effect of the Earth's revolution around the sun on these event rates is also studied by folding with a Maxwellian LSP-velocity distribution which is consistent with its density in the halos. We thus found that the convoluted event rates do not appreciably change compared to those obtained with an average velocity. The event rates increase with A and, in the SUSY parameter space considered, they can reach values up to 140 $y^{-1}Kg^{-1}$ for Pb. The modulation effect, however, was found to be small (less than $\pm 5$).Comment: 23 LATEX pages, 4 Tables, 3 PostScript Figures included. Phys. Rev. D, to be publishe

Discriminative stimulus effects of etorphine in rhesus monkeys

Two rhesus monkeys were trained to discriminate the IM injection of etorphine (0.001 mg/kg) from saline in a task in which 20 consecutive responses on one of two levers resulted in food delivery. In both monkeys, etorphine (0.0001–0.0018), meperidine (0.1–1.0 mg/kg), morphine (0.1–3.2 mg/kg), and codeine (0.3–3.2) produced dose-related increases in the percentage of total session responses that occurred on the etorphine-appropriate lever. In contrast, ethylketazocine, SKF-10047, and pentazocine, at doses up to and including those that suppressed response rates, produced responses primarily on the saline-appropriate lever. Thus, etorphine-like narcotics, including morphine, have discriminative stimulus effects in rhesus monkeys which can be distinguished from those produced by narcotics with nonmorphine-like actions such as ethylketazocine, SKF-10047, and pentazocine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46422/1/213_2004_Article_BF00431828.pd