Efficiency and Patient-Reported Outcome Measures From Clinic to Home: The Human Empowerment Aging and Disability Program for Digital-Health Rehabilitation

Background: The recent exponential growth of Digital Health (DH) in the healthcare system provides a crucial transformation in healthcare, answering to alarming threats related to the increasing number of Chronic Neurological Diseases (CNDs). New long-term integrated DH-care approaches, including rehabilitation, are warranted to address these concerns. Methods: The Human Empowerment Aging and Disability (HEAD) rehabilitation program, a new long-term integrated care including DH-care system, was evaluated in terms of efficiency and patient-reported outcome measures (PROMs) in 107 CND patients (30 with Parkinson's Disease, PD; 32 with Multiple Sclerosis, MS; 45 with stroke in chronic stage). All participants followed 1-month of HEAD rehabilitation in clinic (ClinicHEAD: 12 sessions, 3/week), then 1:3 patient was consecutively allocated to 3-months telerehabilitation at home (HomeHEAD: 60 sessions, 5/week). Efficiency (i.e., adherence, usability, and acceptability) and PROMs (i.e., perceived functioning in real-world) were analyzed. Results: The rate of adherence to HEAD treatment in clinic (≥90%) and at home (77%) was high. Usability of HEAD system was judged as good (System Usability Scale, median 70.00) in clinic and even more at home (median 80.00). Similarly, administering the Technology Acceptance Model 3 questionnaire we found high scores both in clinic/at home (Usefulness, mean 5.39 ± 1.41 SD/mean 5.33 ± 1.29 SD; Ease of use, mean 5.55 ± 1.05 SD/ mean 5.45 ± 1.17 SD, External Control, mean 4.94 ± 1.17 SD/mean 5.07 ± 1.01 SD, Relevance, mean 5.68 ± 1.29 SD/mean 5.70 ± 1.13 SD and Enjoyment, mean 5.70 ± 1.40 SD/mean 6.01 ± 1.08 SD). After ClinicHEAD, participation and autonomy in daily routine was maintained or even ameliorated (PD and stroke > MS). Whereas, increased functionality and participation in the MS group was found only after HomeHEAD intervention. Discussion: Our results suggest that a tele-health-based approach is both feasible and efficient in providing rehabilitation care to CNDs from clinic to home. Increasing and maintaining participation as well as autonomy in daily routine are promising findings that open up scenarios for the continuity of care at home through DH-care for CNDs

Design and Analysis of the Cis-Lunar Navigation for the ArgoMoon CubeSat Mission

In the framework of the Artemis-1 mission, 10 CubeSats will be released, including the 6U CubeSat ArgoMoon, built by the Italian company Argotec and coordinated by the Italian Space Agency. The primary goal of ArgoMoon is to capture images of the Interim Cryogenic Propulsion Stage. Then, ArgoMoon will be placed into a highly elliptical orbit around the Earth with several encounters with the Moon. In this phase, the navigation process will require a precise Orbit Determination (OD) and a Flight Path Control (FPC) to satisfy the navigation requirements. The OD will estimate the spacecraft trajectory using ground-based radiometric observables. The FPC is based on an optimal control strategy designed to reduce the dispersion with respect to the reference trajectory and minimize the total ΔV. A linear approach was used to determine the optimal targets and the number and location of the orbital maneuvers. A covariance analysis was performed to assess the expected OD performance and its robustness. The analysis results show that the reference translunar trajectory can be successfully flown and the navigation performance is strongly dependent on the uncertainties of the ArgoMoon’s Propulsion Subsystem and of the orbit injection

The Hera Radio Science Experiment at Didymos

Hera represents the European Space Agency's inaugural planetary defence space mission, and plays a pivotal role in the Asteroid Impact and Deflection Assessment international collaboration with NASA DART mission that performed the first asteroid deflection experiment using the kinetic impactor techniques. With the primary objective of conducting a detailed post-impact survey of the Didymos binary asteroid following the DART impact on its small moon called Dimorphos, Hera aims to comprehensively assess and characterize the feasibility of the kinetic impactor technique in asteroid deflection while conducting in-depth investigation of the asteroid binary, including its physical and compositional properties as well as the effect of the impact on the surface and/or shape of Dimorphos. In this work we describe the Hera radio science experiment, which will allow us to precisely estimate key parameters, including the mass, which is required to determine the momentum enhancement resulting from the DART impact, mass distribution, rotational states, relative orbits, and dynamics of the asteroids Didymos and Dimorphos. Through a multi-arc covariance analysis we present the achievable accuracy for these parameters, which consider the full expected asteroid phase and are based on ground radiometric, Hera optical images, and Hera to CubeSats InterSatellite Link radiometric measurements. The expected formal uncertainties for Didymos and Dimorphos GM are better than 0.01% and 0.1%, respectively, while their J2 formal uncertainties are better than 0.1% and 10%, respectively. Regarding their rotational state, the absolute spin pole orientations of the bodies can be recovered to better than 1 degree, and Dimorphos spin rate to better than 10^-3%. Dimorphos reconstructed relative orbit can be estimated at the sub-m level [...

PARSIFAL: a toolkit for triple-GEM parametrized simulation

PARSIFAL (PARametrized SImulation) is a tool which reproduces a triple-GEM detector full response to the passage of a charged particle, taking into account most of the involved physical effects. A triple-GEM is a gaseous detector that amplifies the primary ionization, generated by the incoming radiation interacting with the gas, through three amplification stages, providing position measurement with a resolution around 100 micron, energy resolution better than 20% and time resolution below 10 ns. Despite well known and robust software such as GARFIELD++ can simulate the electron propagation in gas and the interaction with the electric field, considering the avalanche formation and signal creation, they are CPU-time consuming. The necessity to reduce the processing time while maintaining the precision of a full simulation is the main driver of this work. PARSIFAL takes into account the main processes involved in the signal formation, starting from ionization, spatial and temporal diffusion, the effect of the magnetic field, if any, and GEM amplification properties. The induction of the signal and the electronics response are also present. PARSIFAL parameters are evaluated by means of GARFIELD++ simulations; the results of the simulation are compared to experimental data from testbeam and tuning factors are applied to improve the matching.Comment: submitted to JINS

Track-based alignment for the BESIII CGEM detector in the cosmic-ray test

The Beijing Electron Spectrometer III (BESIII) is a multipurpose detector operating on the Beijing Electron Positron Collider II (BEPCII). After more than ten year's operation, the efficiency of the inner layers of the Main Drift Chamber (MDC) decreased significantly. To solve this issue, the BESIII collaboration is planning to replace the inner part of the MDC with three layers of Cylindrical triple-Gas Electron Multipliers (CGEM). The new features of the CGEM detector will improve the spatial resolution to 130 $\mu$m. To meet this goal, a careful calibration of the detector is necessary to fully exploit the potential of the CGEM detector. In all the calibrations, the detector alignment plays an important role to improve the detector precision. The track-based alignment for the CGEM detector with the Millepede algorithm is implemented to reduce the uncertainties of the hit position measurement. Using the cosmic-ray data taken in 2020 with the two layers setup, the displacement of the outer layer with respect to the inner layer is determined by a simultaneous fit applied to more than 160000 tracks. A good alignment precision has been achieved that guarantees the design request could be satisfied in the future. A further alignment will be performed using the combined information of tracks from cosmic-ray and collisions after the CGEM is installed into the BESIII detector

Observation of Ξ−\Xi^{-} Hyperon Transverse Polarization in ψ(3686)→Ξ−Ξˉ+\psi(3686)\rightarrow\Xi^{-}\bar\Xi^{+}

Using a sample of $(448.1~\pm~2.9)$ $\times 10^{6}$ $\psi(3686)$ decays collected with the BESIII detector at BEPCII, we report an observation of $\Xi^{-}$ transverse polarization with a significance of $7.3 \sigma$ in the decay $\psi(3686)\rightarrow\Xi^{-}\bar\Xi^{+}$ ($\Xi^{-}\rightarrow\pi^{-}\Lambda$, $\bar\Xi^{+}\rightarrow\pi^{+}\bar\Lambda$, $\Lambda\to p\pi^{-}$, $\bar\Lambda\to\bar{p}\pi^{+}$). The relative phase of the electric and magnetic form factors is determined to be $\Delta\Phi = (0.667 \pm 0.111 \pm 0.058)$ rad. This is the first measurement of the relative phase for a $\psi(3686)$ decay into a pair of $\Xi^{-}\bar\Xi^{+}$ hyperons. The $\Xi^{-}$ decay parameters ($\alpha_{\Xi^{-}}$, $\phi_{\Xi^-}$) and their conjugates ($\alpha_{\bar\Xi^{+}}$, $\phi_{\bar{\Xi}^{+}}$), the angular-distribution parameter $\alpha_{\psi}$, and the strong-phase difference $\delta_{p}-\delta_{s}$ for $\Lambda$-$\pi^-$ scattering are measured to be consistent with previous BESIII results.Comment: 8 pages, 3 figures, consistent with paper published in Phys. Rev. D (Letter) 106, L091101 (2022