Cancer in women in Kerala - a transition from a less-developed state

An epidemiologic assessment of the problem of cancer in women in Kerala based on 3 Population Cancer Registry data and a Hospital Based data is presented. Kerala's Socio-economic and demography presents an intermediate development from a less developed to a better-developed state. As yet, the women follow a tradition-based life style. Cancer incidence rate in Kerala was only 80% of urban rates than seen in Urban Metropolis in India. The pattern of site distribution has shown that GI, Breast & Cervix cancers are the predominant cancers. Oral cavity cancers also show a high frequency. Thyroid cancer has a higher incidence rate in Kerala compared to other areas. Lung cancer among women has higher incidence rate in Karunagappally women. A high prevalence of tobacco use is reported among the men in the above area. Breast cancer incidence rate in the rural areas was only 60% of the rate seen in Urban Trivandrum. Unlike in other rural and urban areas of India Cervix cancer has a low incidence rate in Kerala women. This may be due to better education and also due to the changes in marital and other life style practices. Only 15% of cancer patients attend for medical assistance in localized stage of disease. The need for public education is highlighted and focusing on tobacco use control, self-examination and screening

Change in awareness levels of cervical cancer among rural women after intervention by health education: a community-based study

Background: Cervical cancer is the fourth most common cancer among women worldwide. The prevention and control of cervical cancer depends on awareness about the disease, screening procedures, and preventive measures. Objectives of this study was to assess the awareness levels on various aspects of cervical cancer among women aged 25-65 years, and to assess the impact of health education intervention among them.Methods: This community-based interventional study was conducted for a period of 15 months among 250 women aged 25-65 years by cluster sampling method in a rural population. Data on all aspects of awareness about cervical cancer, i.e., risk factors, signs and symptoms, diagnosis and treatment and prevention were collected using a pre-tested semi-structured proforma. This was followed by a post-test 2 months after health education.Results: Overall awareness for cervical cancer was found to be very poor among the study subjects in the pre-test. Awareness on risk factors, signs and symptoms, diagnosis and treatment, and prevention of cervical cancer was found to be 6%, 3.6%, 1.2%, and 1.6% respectively. A significant increase in the knowledge level was found after health education.Conclusions: As the awareness levels regarding the cervical cancer was poor among the study population, health education programme and campaigns, along with periodic screening is need of the hour to effectively prevent cervical cancer

Fracture studies on synthetic fiber reinforced cellular concrete using acoustic emission technique

Cellular lightweight concrete (CLC) is increasingly used for low strength non-structural and structural applications. The effects of synthetic fiber reinforcement on the fracture behavior of CLC is investigated. In particular, acoustic emission (AE) technique is employed to study the influence of macro (structural), micro polyolefin synthetic fibers and their combinations on the fracture behavior of CLC beams. Notched fiber reinforced CLC beams were tested to study the crack initiation and propagation characteristics using AE sensors. Different AE parameters are correlated with the crack growth and damage accumulation. An attempt has been made to correlate the crack mouth opening displacement (CMOD) with the number of AE hits. The variation of cumulative acoustic energy release of the cracks is studied with respect to applied load and CMOD. Three dimensional source location of cracks is carried out based on the AE events picked by the sensors bonded to the CLC specimens. The analysis of AE results indicates that the crack source location identification from AE is consistent with the actual crack development. Analysis of AE signals reveal that the CLC matrix cracking produces signals with less number of hits that lie in the notched plane in bending. Moreover, the signals from the post peak regime correspond to more number of hits which tend to be scattered around the plane of notch due to the fiber pull out

Can pixel value ratio be used in the assessment of ceramic bone substitute incorporation? : observations from a pilot study

Background: Assessment of bone graft substitute incorporation is critical in the clinical decision making process and requires special investigations. We examined if the pixel value ratio (PVR) obtained in routine follow-up digital radiographs could be used for such assessment. Material/Methods: Radiographic images were acquired using either computed radiography or flat panel digital radiography systems. The PVR from radiographs of thirty children with ceramic bone substitute grafting were analyzed using the software from the picture archival and communication system (PACS) workstation. Graft incorporation was also assessed using the van Hemert scale. Three independent observers (A, B, C) measured PVRs at two different time points during the first and the last follow-up visits. PVR was compared with the van Hemert scale scores and analyzed using Spearman's rank correlation. Results: The mean intra-observer reliability was 0.8996, and inter-observer reliabilities were 0.69 (A vs. C), 0.78 (A vs. B), and 0.85 (B vs. C) for the first follow-up visit and 0.74 (A vs. C), 0.82 (A vs. B), and 0.70 (B vs. C) for the last follow-up measurements. Spearman's correlation showed a strong negative association between PVR values and van Hemert scale scores, as the healing process advanced on serial measurements at each follow-up (r=-0.94, n=60, z=-7.24, p£0.0001). The reliability of the PVR measurements was assessed using an aluminum step wedge and ceramic graft. Conclusions: PVR is potentially a reliable indicator of bone graft incorporation and can aid in clinical decision making provided standard radiographic techniques are used

Co-ordinate Control for Fuel Cell And Photovoltaic Cell

The usual natural fuel energy resources such as petroleum, natural gas, and coal are getting shortage rapidly by fulfilling the high demand of the energy sector in the world. Also, affect the environment and leads to the greenhouse effect and serious pollution problem. Therefore renewable energy sources like solar, wind, tidal etc. are gaining more attention as an alternative energy. The hierarchical structure of the convention power system is experiencing a paradigm shift into a deregulated system. As a result many small generators are been connected to the system at the distribution level. In order to supply a reliable and sustainable power to select customers it becomes mandatory to connect renewable and dispatchable sources. This would result in a hybrid system which can operate in autonomous or non-autonomous mode. This project aims at analysing the performance of one such autonomous system for varying demand. PV and fuel cell sources are considered to form the hybrid system under concern. An overall coordinated controller has been analysed to ensure power sharing among the different sources used in the hybrid system also incorporating variations in the solar irradiations. Also a simulation for generation of pulses for appropriate switching of control between the different sources through MATLAB has been attempted in this work

FEKETE-SZEGO PROBLEM FOR CONCAVE UNIVALENT FUNCTIONS ASSOCIATED WITH FOX-WRIGHT'S GENERALIZED HYPERGEOMETRIC FUNCTIONS

We investigate the Fekete-Szego problem with real and complex parameter $\lambda$ for the class Co(\lambda) of concave univalent functions dened by Fox-Wright's generalisedhypergeometric function.Mathematics Subject Classication: Primary 30C45Keywords: Concave, Univalent, Starlike functions, Fox-Wright's generalised hypergeometricfunctio

Gene delivery to in situ veins: Differential effects of adenovirus and adeno-associated viral vectors

AbstractPurpose: Gene transfer offers the potential to modify vein graft biology at the time of surgical implantation. Efficiency of gene delivery, stability of expression, and host responses are critical parameters for candidate vectors. We compared the effects of intraluminal exposure with adenovirus (AD) and adeno-associated virus (AAV) vectors on transgene expression and monocyte adhesion (MA) in treated vein segments. Methods: Adult New Zealand white rabbits (N = 51) were anesthetized, and the jugular veins were cannulated bilaterally. Veins were gently distended with either vector (2·108 to 1·1010 infective particles/mL) or vehicle (control) for 30 minutes, after which venous flow was restored. AD and AAV vectors encoding for the marker genes β-galactosidase (LacZ) and green fluorescent protein (GFP) were used. Vessels were explanted 2 to 40 days postinfection for analysis of gene expression (X-gal staining, reverse transcriptase-polymerase chain reaction), MA, and immunohistochemistry. Ex vivo adhesion assays used 51Cr-labeled THP-1 cells. Statistical significance was tested by using analysis of variance with a P value less than.05. Results: All animals survived, and all treated veins were patent at sacrifice. Intraluminal exposure to AD at a titer of 1·109 resulted in near complete transduction of the endothelium at 2 days, with no detectable expression by day 14. At an equal titer of infectious particles, transgene expression was markedly less for AAV at 2 to 7 days, but improved at 2 weeks and persisted to 40 days. MA was significantly increased 2 days after AD exposure (2.7-fold vs control, *P <.002); AAV treatment had no discernible effect on MA. Conclusion: AD-mediated gene transfer to vein segments resulted in robust, transient gene expression that disappeared after 2 weeks. In comparison, AAV-mediated gene delivery was less efficient, but resulted in delayed onset, persistent expression beyond 30 days. AD exposure induced an early increase in MA to the vein surface that was not seen with AAV treatment. Current generations of both AD and AAV vectors have significant, albeit different, limitations for vascular gene therapy. (J Vasc Surg 2000;31:1149-59.

Assessing fracture risk in people with MS: a service development study comparing three fracture risk scoring systems

Objectives Suboptimal bone health is increasingly recognised as an important cause of morbidity. Multiple sclerosis (MS) has been consistently associated with an increased risk of osteoporosis and fracture. Various fracture risk screening tools have been developed, two of which are in routine use and a further one is MS-specific. We set out to compare the results obtained by these in the MS clinic population. Design This was a service development study. The 10-year risk estimates of any fracture and hip fracture generated by each of the algorithms were compared. Setting The MS clinic at the Royal London Hospital. Participants 88 patients with a confirmed diagnosis of MS. Outcome measures Mean 10-year overall fracture risk and hip fracture risk were calculated using each of the three fracture risk calculators. The number of interventions that would be required as a result of using each of these tools was also compared. Results Mean 10-year fracture risk was 4.7%, 2.3% and 7.6% using FRAX, QFracture and the MS-specific calculator, respectively (p<0.0001 for difference). The agreement between risk scoring tools was poor at all levels of fracture risk. Conclusions The agreement between these three fracture risk scoring tools is poor in the MS population. Further work is required to develop and validate an accurate fracture risk scoring system for use in MS. Trial registration This service development study was approved by the Clinical Effectiveness Department at Barts Health NHS Trust (project registration number 156/12).g RD is funded by an Association of British Neurologists/MS Society of Great Britain Clinical Research Fellowship. GG receives grant support from the MRC, National MS Society, MS Society of Great

Depth-Resolved Multispectral Sub-Surface Imaging Using Multifunctional Upconversion Phosphors with Paramagnetic Properties

Molecular imaging is very promising technique used for surgical guidance, which requires advancements related to properties of imaging agents and subsequent data retrieval methods from measured multispectral images. In this article, an upconversion material is introduced for subsurface near-infrared imaging and for the depth recovery of the material embedded below the biological tissue. The results confirm significant correlation between the analytical depth estimate of the material under the tissue and the measured ratio of emitted light from the material at two different wavelengths. Experiments with biological tissue samples demonstrate depth resolved imaging using the rare earth doped multifunctional phosphors. In vitro tests reveal no significant toxicity, whereas the magnetic measurements of the phosphors show that the particles are suitable as magnetic resonance imaging agents. The confocal imaging of fibroblast cells with these phosphors reveals their potential for in vivo imaging. The depth-resolved imaging technique with such phosphors has broad implications for real-time intraoperative surgical guidance