1,047 research outputs found

    Light scattering from a rough metal surface: theory and experiment

    Get PDF
    There is still great interest in the determination of microtopographic properties of rough metallic surfaces from light scattering measurements. According to Beckmann–Kirchhoff theory a clear relationship is established between the in-plane angular scattered light intensity and the statistical properties of the surface. We discuss one way to invert this relationship, and we introduce a new iterative procedure to retrieve the height autocorrelation function even for a very rough metallic surface (rms surface roughness of the same order of the optical wavelength). The procedure is eventually applied to the experimental data of a known metallic surface for validation

    From autism to eating disorders and more: The role of oxytocin in neuropsychiatric disorders

    Get PDF
    Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally, through the neurohypophysis, oxy is secreted into the systemic circulation to act as a hormone, thereby influencing several body functions. Oxy plays a pivotal role in parturition, milk let-down and maternal behavior and has been demonstrated to be important in the formation of pair bonding between mother and infants as well as in mating pairs. Furthermore, oxy has been proven to play a key role in the regulation of several behaviors associated with neuropsychiatric disorders, including social interactions, social memory response to social stimuli, decision-making in the context of social interactions, feeding behavior, emotional reactivity, etc. An increasing body of evidence suggests that deregulations of the oxytocinergic system might be involved in the pathophysiology of certain neuropsychiatric disorders such as autism, eating disorders, schizophrenia, mood, and anxiety disorders. The potential use of oxy in these mental health disorders is attracting growing interest since numerous beneficial properties are ascribed to this neuropeptide. The present manuscript will review the existing findings on the role played by oxy in a variety of distinct physiological and behavioral functions (Figure 1) and on its role and impact in different psychiatric disorders. The aim of this review is to highlight the need of further investigations on this target that might contribute to the development of novel more efficacious therapies

    Aging Reveals a Role for Nigral Tyrosine Hydroxylase ser31 Phosphorylation in Locomotor Activity Generation

    Get PDF
    BACKGROUND:Tyrosine hydroxylase (TH) regulates dopamine (DA) bioavailability. Its product, L-DOPA, is an established treatment for Parkinson's disease (PD), suggesting that TH regulation influences locomotion. Site-specific phosphorylation of TH at ser31 and ser40 regulates activity. No direct evidence shows that ser40 phosphorylation is the dominating mechanism of regulating TH activity in vivo, and physiologically-relevant stimuli increase L-DOPA biosynthesis independent of ser40 phosphorylation. Significant loss of locomotor activity occurs in aging as in PD, despite less loss of striatal DA or TH in aging compared to the loss associated with symptomatic PD. However, in the substantia nigra (SN), there is equivalent loss of DA or TH in aging and at the onset of PD symptoms. Growth factors increase locomotor activity in both PD and aging models and increase DA bioavailability and ser31 TH phosphorylation in SN, suggesting that ser31 TH phosphorylation status in the SN, not striatum, regulates DA bioavailability necessary for locomotor activity. METHODOLOGY AND PRINCIPAL FINDINGS:We longitudinally characterized locomotor activity in young and older Brown-Norway Fischer 344 F(1) hybrid rats (18 months apart in age) at two time periods, eight months apart. The aged group served as an intact and pharmacologically-naïve source of deficient locomotor activity. Following locomotor testing, we analyzed DA tissue content, TH protein, and TH phosphorylation in striatum, SN, nucleus accumbens, and VTA. Levels of TH protein combined with ser31 phosphorylation alone reflected inherent differences in DA levels among the four regions. Measures strictly pertaining to locomotor activity initiation significantly correlated to DA content only in the SN. Nigral TH protein and ser31 phosphorylation together significantly correlated to test subject's maximum movement number, horizontal activity, and duration. CONCLUSIONS/SIGNIFICANCE:Together, these results show ser31 TH phosphorylation regulates DA bioavailability in intact neuropil, its status in the SN may regulate locomotor activity generation, and it may represent an accurate target for treating locomotor deficiency. They also show that neurotransmitter regulation in cell body regions can mediate behavioral outcomes and that ser31 TH phosphorylation plays a role in behaviors dependent upon catecholamines, such as dopamine

    Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats

    Get PDF
    Previous studies have suggested that administration of oxytocin (OT) can have modulatory effects on social and anxiety-like behavior in mammals that may endure beyond the time of acute OT administration. The current study examined whether repeated administration of OT to male Wistar rats (n = 48) during a key developmental epoch (early adolescence) altered their physiology and behavior in later-life. Group housed rats were given intraperitoneal injections of either 1 mg/kg OT or vehicle during early adolescence (post natal-days [PND] 33–42). OT treatment caused a transient inhibition of body weight gain that recovered quickly after the cessation of treatment. At PND 50, the rats pre-treated with OT displayed less anxiety-like behavior on the emergence test, while at PND 55 they showed greater levels of social interaction. A subgroup of OT pre-treated rats examined at PND 63 showed a strong trend towards increased plasma OT levels, and also displayed significantly increased OT receptor mRNA in the hypothalamus. Rats pre-treated with OT and their controls showed similar induction of beer intake in daily 70 min test sessions (PND 63 onwards) in which the alcohol concentration of beer was gradually increased across days from 0.44% to 4.44%. However, when given ad libitum access to beer in their home cages from PND 72 onwards (early adulthood), consumption of beer but not water was significantly less in the OT pre-treated rats. A “booster” shot of OT (1 mg/kg) given after 25 days of ad libitum access to beer had a strong acute inhibitory effect on beer intake without affecting water intake. Overall these results suggest that exogenous OT administered during adolescence can have subtle yet enduring effects on anxiety, sociability and the motivation to consume alcohol. Such effects may reflect the inherent neuroplasticity of brain OT systems and a feed-forward effect whereby exogenous OT upregulates endogenous OT systems

    Il paesaggio che cambia

    Get PDF
    Convegno: Paesaggio Rurale \u2013 Paesaggio Cultural

    Effects of water stress on spectral reflectance of bermudagrass

    Get PDF
    In the south-central Italy, during summer rainfall does not supply a sufficient amount of water. Therefore, irrigation management during dry periods is important for maintaining turf quality. The hybrid bermudagrass (Cynodon dactylon (L.) Pers. × Cynodon transvaalensis Burtt–Davy) is known to represent the dominant warm-season turfgrass in warm to temperate climatic regions and its drought tolerance make bermudagrass a competitive turfgrass. A greenhouse experiment was conducted using uniform cores of hybrid bermudagrass, which were secured in a polyvinyl chloride cylinders and watered by constant sub-irrigation. The objectives of the present research were to measure the spectral reflectance with a new generation handheld spectroradiometer on hybrid bermudagrass and to explore various vegetation indices to be used as future detecting tool to study water stress in bermudagrass. Moreover, the potential uses of multivariate processing techniques for discriminating different water stress conditions in turfgrass has been investigated. Besides spectral indices, multivariate methods, although performed on a data set limited in terms of sample size, have shown a great potential for water stress monitoring in turfgrass and surely deserve further investigations. There are different indices that use distinct water absorption features independent of chlorophyll concentration, such as water index (WI = R900/R970) that has been reported to be a robust index of canopy water content and is used as an active indicator of changes in Leaf Relative Water Content (LRWC). Also, the ratio of WI with NDVI (WI/NDVI = (R900/R970)/((R800 − R680)/(R800 + R680)]) was found to be an effective indicator of water stress. Another vegetation index to detect water features is normalized difference water index (NDWI), designed to maximize reflectance of water by using green wavelengths. In our trial in bermudagrass the relationships studied, suggest that WI (900/970) and WI/NDVI, among the indices studied, are the more effective indicators of water stress. In fact, lower values of WI indicate higher water stress, while higher values of WI/NDVI indicate higher water stress levels

    WCDRR and the CEOS activities on disaters

    Get PDF
    Agencies from CEOS (Committee on Earth Observation Satellites) have traditionally focused their efforts on the response phase. Rapid urbanization and increased severity of weather events has led to growing economic and human losses from disasters, requiring international organisations to act now in all disaster risk management (DRM) phases, especially through improved disaster risk reduction policies and programmes. As part of this effort, CEOS agencies have initiated a series of actions aimed at fostering the use of Earth observation (EO) data to support disaster risk reduction and at raising the awareness of policy and decision-makers and major stakeholders of the benefits of using satellite EO in all phases of DRM. CEOS is developing a long-term vision for sustainable application of satellite EO to all phases of DRM. CEOS is collaborating with regional representatives of the DRM user community, on a multi-hazard project involving three thematic pilots (floods, seismic hazards and volcanoes) and a Recovery Observatory that supports resilient recovery from one major disaster. These pilot activities are meant as trail blazers that demonstrate the potential offered by satellite EO for comprehensive DRM. In the framework of the 2015 3rd World Conference on Disaster Risk Reduction (WCDRR), the CEOS space agencies intend to partner with major stakeholders, including UN organizations, the Group on Earth Observations (GEO), international relief agencies, leading development banks, and leading regional DRM organisations, to define and implement a 15-year plan of actions (2015- 2030) that responds to high-level Post-2015 Framework for Disaster Risk Reduction priorities. This plan of action will take into account lessons learned from the CEOS pilot activities

    Experimental observation of non-ideal expanding flows of Siloxane MDM vapor for ORC applications

    Get PDF
    Abstract Extensive experimental results characterizing the supersonic expansion of an organic vapor in non-ideal conditions are reported in this paper for the first time. The collected data also allowed the assessment of the accuracy of Computational Fluid Dynamic (CFD) tools employed to predict the non-ideal behavior of such flows, including the consistency of thermodynamic models adopted. The investigation has been carried out on the converging-diverging nozzle test section of the Test Rig for Organic VApors (TROVA), at the Laboratory of Compressible fluid-dynamics for Renewable Energy Application (CREA) of Politecnico di Milano. Supersonic nozzle flow was chosen as the simplest one of significance for organic Rankine cycle (ORC) turbine channels. The working fluid under scrutiny is Siloxane MDM, a widely employed compound for high temperature ORCs. MDM vapor expands through the TROVA nozzle at moderate non-ideal conditions in the close proximity of the vapor saturation curve. This is the region where ORC expanders typically operate, thus proving the relevance of the investigation for the ORC community. Indeed, detailed experimental data representative of typical ORC expansions were lacking in the open literature up to date. Two different nozzle geometries, featuring exit Mach number of 2.0 and 1.5 respectively, were tested, exploring a wide range of thermodynamic inlet conditions and diverse levels of non-ideality, from moderate non-ideal state, indicated by a compressibility factor Z = Pv/RT ≃ 0.80, to dilute gas conditions, Z ≥ 0.97. Maximum operating total pressure and temperature are Pt ≃ 5 bar and T T ≃ 250 °C. The nozzle flow is characterized in terms of total pressure, total temperature, static pressure at discrete locations along the nozzle axis, and schlieren imaging. In contrast to the well known case of polytropic ideal gas, the vapor expansion through the nozzle is found to be dependent on the inlet conditions, thus proving the non-ideal character of the flow. This influence is found to be consistent with the one predicted by the quasi-1D theory coupled with simple non-ideal gas models. Experimental data at the nozzle centerline are compared with those resulting from a two-dimensional viscous CFD calculation carried out using the SU2 software suite and the improved Peng Robinson Stryjek Vera (iPRSV) thermodynamic model. A very good accordance is found, demonstrating the high accuracy of the applied tools

    St. Augustinegrass accessions planted in northern, central and southern Italy: Growth and morphological traits during establishment

    Get PDF
    The use of warm season turfgrasses is a consolidated trend in the climatic transition zone of Mediterranean countries, in particular St. Augustinegrass (Stenotaphrum secundatum (Walt.) Kuntze) begins to be widespread in warm coastal areas. However, little is known about the performance of the different cultivars of this species in southern Europe. In 2016-2017 a trial was carried out in three locations in Italy, Padova, Pisa. and Palermo, located in the north, center and south of the country respectively. Four cultivars (Floratine, Captiva, Sapphire, Pahnetto) and five ecotypes (CeRTES 201, CeRTES 202, CeRTES 203, CeRTES 204, CeRTES 205) were compared in terms of their growth characteristics and morphological traits during establishment. The results highlighted that stolon growth was significantly affected by the location, as well as green colour retention. Stolon growth rate, internode length and internode volume and turf quality were, however, significantly determined by the accession effect. The quality of the ecotypes was also in some cases comparable to that of the cultivars. In Padova, winterkill occurred in most of the accessions, while in Pisa and Palermo, all the entries survived. In conclusion. St. Augustinegrass is suitable for turf use in the central and southern coastal area of Italy
    corecore