Parametrised modified gravity and the CMB Bispectrum

We forecast the constraints on modified theories of gravity from the cosmic microwave background (CMB) anisotropies bispectrum that arises from correlations between lensing and the Integrated Sachs-Wolfe effect. In models of modified gravity the evolution of the metric potentials is generally altered and the contribution to the CMB bispectrum signal can differ significantly from the one expected in the standard cosmological model.We adopt a parametrised approach and focus on three different classes of models: Linder's growth index, Chameleon-type models and f(R) theories. We show that the constraints on the parameters of the models will significantly improve with future CMB bispectrum measurements.Comment: 7 pages, 6 figure

Complete analysis of measurement-induced entanglement localization on a three-photon system

We discuss both theoretically and experimentally elementary two-photon polarization entanglement localization after break of entanglement caused by linear coupling of environmental photon with one of the system photons. The localization of entanglement is based on simple polarization measurement of the surrounding photon after the coupling. We demonstrate that non-zero entanglement can be localized back irrespectively to the distinguishability of coupled photons. Further, it can be increased by local single-copy polarization filters up to an amount violating Bell inequalities. The present technique allows to restore entanglement in that cases, when the entanglement distillation does not produce any entanglement out of the coupling.Comment: 14 pages, 14 figures, submitted to Phys. Rev.

Overview of the JET results in support to ITER

The 2014–2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its installation in 2011. New multi-machine scaling of the type I-ELM divertor energy flux density to ITER is supported by first principle modelling. ITER relevant disruption experiments and first principle modelling are reported with a set of three disruption mitigation valves mimicking the ITER setup. Insights of the L–H power threshold in Deuterium and Hydrogen are given, stressing the importance of the magnetic configurations and the recent measurements of fine-scale structures in the edge radial electric. Dimensionless scans of the core and pedestal confinement provide new information to elucidate the importance of the first wall material on the fusion performance. H-mode plasmas at ITER triangularity (H = 1 at βN ~ 1.8 and n/nGW ~ 0.6) have been sustained at 2 MA during 5 s. The ITER neutronics codes have been validated on high performance experiments. Prospects for the coming D–T campaign and 14 MeV neutron calibration strategy are reviewed.European Commission (EUROfusion 633053

Yorick's Whiskers: the poetics of T. Tolstaya's small prose and its translations into English

The objective of the study is to educe the particular features of T. Tolstaya's small prose. Her texts are characterized by a high density of literary meanings and great complexity of literary structure. The article explores the correlations between these two phenomena by analyzing the short story “Yorick” and its translation into English. We uncover the literary meanings of the text, which are formed by means of a number of global cultural contexts (biographical, historical, literary, and mythopoetical). We also study the form that they take in Tolstaya's literary discourse and provide a comparative analysis of the discoursive literary techniques used by the author and their rendering by the translator. Both the analysis technique and the materials presented in the article can be used in teaching literary translation to students of Russian or English

Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity

Background and aim: Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk. SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. We aimed to assess the relationship of EF thickness (EFT) with circulating SIRT1 in patients with obesity. Methods and results: Sixty-two patients affected by obesity and 23 lean controls were studied. Plasma SIRT1 concentration was determined by enzyme-linked immunosorbent assay (ELISA). EFT was measured by echocardiography. Body mass index (BMI), waist circumference, heart rate (HR), blood pressure, and laboratory findings (fasting glucose, insulin, HbA1c, cholesterol, and triglycerides) were assessed. SIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls. SIRT1 showed a negative correlation with EFT and HR in the obesity group (rho = -0.350, P = 0.005; rho = -0.303, P = 0.008, respectively). After adjustment for obesity-correlated variables, multiple linear regression analysis showed that EFT remained the best correlate of SIRT1 (beta = -0.352, P = 0.016). Conclusions: Circulating SIRT1 correlates with the visceral fat content of the heart. Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved

The relationship of adverse childhood experiences, hair cortisol, C-reactive protein, and polygenic susceptibility with older adults’ psychological distress during the COVID-19 pandemic

Adverse childhood experiences (ACEs) are linked to poorer mental health outcomes, and growing evidence implicates biological and genetic pathways from early adversity to psychopathology. However, little is known about the relationship of ACEs and their underlying biological and genetic mechanisms with older people’s mental health responses to the COVID-19 pandemic. We tested the associations of ACEs, hair cortisol, C-reactive protein (CRP), and polygenic scores (PGS) with depression, anxiety, and loneliness among older adults during the COVID-19 pandemic, accounting for the potential interplay of ACEs with biological and genetic risk markers. Data were drawn from the English Longitudinal Study of Ageing, a prospective cohort study of older adults living in England. Retrospective information on ACEs were collected in 2006/7, while CRP and hair cortisol were measured at wave 6 (2012/13). Psychological distress was assessed before the pandemic (2018–19) and at two COVID-19 assessments in 2020 (June-July and November-December). Associations were tested on 2050 participants using linear/logistic regression models adjusted for pre-pandemic outcome measures and mixed-effect models to assess changes before and during the pandemic. The results showed that ACEs were associated with higher levels of depression (OR = 2.55[95%CI:1.81,3.59]) anxiety (OR = 1.84[95%CI:1.13,3.01]), and loneliness (b = 0.28[95%CI:0.14,0.42]) during the pandemic. Hair cortisol was related to an increased risk of depression (OR = 1.15[95%CI:1.04,1.26]), and CRP was associated with greater loneliness scores (b = 0.16[95%CI:0.03,0.30]). The relationship between cortisol and psychological distress was larger among participants with ACEs (e.g., ORdepression = 1.07[95%CI:1.00,1.14]). Further, individuals with high CRP experienced greater increases in feelings of loneliness from before to during the pandemic, compared to those with lower CRP levels (interaction effect=0.23; 95%CI:0.1–0.37). Individuals with 2+ ACEs experienced greater increases in depressive symptoms compared to those with none (interaction effect=2.09; 95%CI:1.1–3.98). Higher levels of hair cortisol were also related to worse changes in depressive symptoms across timepoints (interaction effect=1.84;95%CI:1.41–2.41). These results highlight the lasting impact of biosocial vulnerabilities on older adults’ mental health responses to new environmental stressors. They also implicate biological mechanisms in the pathophysiology of later-life psychological distress

Ultrafast Spectroscopy with Photocurrent Detection: Watching Excitonic Optoelectronic Systems at Work.

While ultrafast spectroscopy with photocurrent detection was almost unknown before 2012, in the last 3 years, a number of research groups from different fields have independently developed ultrafast electric probe approaches and reported promising pilot studies. Here, we discuss these recent advances and provide our perspective on how photocurrent detection successfully overcomes many limitations of all-optical methods, which makes it a technique of choice when device photophysics is concerned. We also highlight compelling existing problems and research questions and suggest ways for further development, outlining the potential breakthroughs to be expected in the near future using photocurrent ultrafast optical probes.A.A.B. is currently a Royal Society University Research Fellow. A.A.B. also acknowledges a VENI grant from the NWO. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 639750). C.S. acknowledges funding from the Natural Science and Engineering Research Council of Canada, the Fonds de recherche du Québec–nature et technologies, the Canada Research Chair in Organic Semiconductor Materials, and the Université de Montréal Research Chair. C.S. and E.V. acknowledge collaboration with Sachetan Tuladhar, Michelle Vezie, Sheridan Few, Jenny Nelson, Hao Li, and Eric Bittner. Finally, C.S. and E.V. acknowledge essential discussions with Andy Marcus and Julia Widom for the implementation of the two-dimensional spectroscopy apparatus.This is the author accepted manuscript. The final version is available from the American Chemical Society via http://dx.doi.org/10.1021/acs.jpclett.5b0195

Soil salinization in marshes : study case: Samborombón Bay wetland, Argentina

En el sector sur de la Bahía de Samborombón (Buenos Aires, Argentina) se desarrolla una extensa marisma que forma un humedal intermareal. En ella se realizaron distintas obras de ingeniería con el fin de evitar el ingreso del flujo mareal y lograr una mayor extensión del área de pastoreo. El objetivo del trabajo es evaluar si la regulación de los flujos mareales ocasiona una modificación en el contenido de cloruros en los sedimentos superficiales, afectando la salinidad de los suelos del humedal. Se realizaron interpretaciones de imágenes satelitales, relevamientos de campo, muestreos de sedimentos y mediciones de niveles y conductividad eléctrica del agua superficial y subterránea. Los resultados obtenidos permitieron reconocer cómo las obras de ingeniería (terraplenes de contención y caminos internos) alteran el comportamiento hidrológico natural y en consecuencia el contenido de cloruros en el sedimento. Problemas de salinización de suelos se reconocen en sectores donde el agua mareal se acumula y luego se evapora formando precipitados de halita. Las futuras obras deberán planificarse de forma tal de minimizar la alteración de los flujos de agua con el fin de lograr un manejo sustentable de los recursos naturales en el humedal.The southern sector of the Samborombón Bay (Buenos Aires, Argentina) is an extensive marsh that is associated with an intertidal wetland environment. Different engineering works were built to avoid tidal inflow and to increase the livestock grazing areas. The objective of this work is to assess if the regulation of tidal inflow causes a chloride content change in the surface sediments, affecting the soil salinity of the wetland. Interpretation of satellite images, field surveys, sampling of sediments, and electrical conductivity and levels measurements of surface and groundwater were carried out. The results allowed us to recognize how engineering works (embankments and internal roads) alter the natural hydrological behavior, and, therefore the chloride content in the sediment. Soil salinization problems are recognized in areas where the tidal water accumulates and then evaporates forming halite precipitates. Future engineering works should be planned so as to minimize the alteration of the water flow in order to achieve a sustainable management of natural resources in the wetland.Fil: Carol, Eleonora S.. Universidad Nacional de La PlataFil: Kruse, Eduardo E.. Universidad Nacional de La PlataFil: Cellone, Francisco A.. Universidad Nacional de La Plat

Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow biopsies

<p>Abstract</p> <p>Background</p> <p>Bovine neonatal pancytopenia (BNP) is a syndrome characterised by thrombocytopenia associated with marked bone marrow destruction in calves, widely reported since 2007 in several European countries and since 2011 in New Zealand. The disease is epidemiologically associated with the use of an inactivated bovine virus diarrhoea (BVD) vaccine and is currently considered to be caused by absorption of colostral antibody produced by some vaccinated cows (“BNP dams”). Alloantibodies capable of binding to the leukocyte surface have been detected in BNP dams and antibodies recognising bovine MHC class I and β-2-microglobulin have been detected in vaccinated cattle. In this study, calves were challenged with pooled colostrum collected from BNP dams or from non-BNP dams and their bone marrow hematopoietic progenitor cells (HPC) cultured <it>in vitro</it> from sternal biopsies taken at 24 hours and 6 days post-challenge.</p> <p>Results</p> <p>Clonogenic assay demonstrated that CFU-GEMM (colony forming unit-granulocyte/erythroid/macrophage/megakaryocyte; pluripotential progenitor cell) colony development was compromised from HPCs harvested as early as 24 hour post-challenge. By 6 days post challenge, HPCs harvested from challenged calves failed to develop CFU-E (erythroid) colonies and the development of both CFU-GEMM and CFU-GM (granulocyte/macrophage) was markedly reduced.</p> <p>Conclusion</p> <p>This study suggests that the bone marrow pathology and clinical signs associated with BNP are related to an insult which compromises the pluripotential progenitor cell within the first 24 hours of life but that this does not initially include all cell types.</p