Near-Field Scanning Microwave Microscopy in the Single Photon Regime

The microwave properties of nano-scale structures are important in a wide variety of applications in quantum technology. Here we describe a low-power cryogenic near-field scanning microwave microscope (NSMM) which maintains nano-scale dielectric contrast down to the single microwave photon regime, up to $10^{9}$ times lower power than in typical NSMMs. We discuss the remaining challenges towards developing nano-scale NSMM for quantum coherent interaction with two-level systems as an enabling tool for the development of quantum technologies in the microwave regime

Effects of quasiparticle tunneling in a circuit-QED realization of a strongly driven two-level system

We experimentally and theoretically study the frequency shift of a driven cavity coupled to a superconducting charge qubit. In addition to previous studies, we here also consider drive strengths large enough to energetically allow for quasiparticle creation. Quasiparticle tunneling leads to the inclusion of more than two charge states in the dynamics. To explain the observed effects, we develop a master equation for the microwave dressed charge states, including quasiparticle tunneling. A bimodal behavior of the frequency shift as a function of gate voltage can be used for sensitive charge detection. However, at weak drives the charge sensitivity is significantly reduced by non-equilibrium quasiparticles, which induce transitions to a non-sensitive state. Unexpectedly, at high enough drives, quasiparticle tunneling enables a very fast relaxation channel to the sensitive state. In this regime, the charge sensitivity is thus robust against externally injected quasiparticles and the desired dynamics prevail over a broad range of temperatures. We find very good agreement between theory and experiment over a wide range of drive strengths and temperatures.Comment: 25 pages, 7 figure

Dynamic parity recovery in a strongly driven Cooper-pair box

We study a superconducting charge qubit coupled to an intensive electromagnetic field and probe changes in the resonance frequency of the formed dressed states. At large driving strengths, exceeding the qubit energy-level splitting, this reveals the well known Landau-Zener-Stuckelberg (LZS) interference structure of a longitudinally driven two-level system. For even stronger drives we observe a significant change in the LZS pattern and contrast. We attribute this to photon-assisted quasiparticle tunneling in the qubit. This results in the recovery of the qubit parity, eliminating effects of quasiparticle poisoning and leads to an enhanced interferometric response. The interference pattern becomes robust to quasiparticle poisoning and has a good potential for accurate charge sensing.Comment: 5 pages, 4 figure

Coupling of a locally implanted rare-earth ion ensemble to a superconducting micro-resonator

We demonstrate the coupling of rare-earth ions locally implanted in a substrate (Gd$^{3+}$ in Al$_{2}$O$_{3}$) to a superconducting NbN lumped-element micro-resonator. The hybrid device is fabricated by a controlled ion implantation of rare-earth ions in well-defined micron-sized areas, aligned to lithographically defined micro-resonators. The technique does not degrade the internal quality factor of the resonators which remain above $10^{5}$. Using microwave absorption spectroscopy we observe electron-spin resonances in good agreement with numerical modelling and extract corresponding coupling rates of the order of $1$ MHz and spin linewidths of $50 - 65$ MHz.Comment: 4 pages, 2 Figure

An effective method to compute closure ordering for nilpotent orbits of θ\theta-representations

We develop an algorithm for computing the closure of a given nilpotent $G_0$-orbit in \g_1, where \g_1 and $G_0$ are coming from a $\Z$ or a $\Z/m\Z$-grading \g= \bigoplus \g_i of a simple complex Lie algebra \g

Fast tunable high Q-factor superconducting microwave resonators

We present fast tunable superconducting microwave resonators fabricated from planar NbN on a sapphire substrate. The $3\lambda/4$ wavelength resonators are tuning fork shaped and tuned by passing a dc current which controls the kinetic inductance of the tuning fork prongs. The $\lambda/4$ section from the open end operates as an integrated impedance converter which creates a nearly perfect short for microwave currents at the dc terminal coupling points, thus preventing microwave energy leakage through the dc lines. We measure an internal quality factor $Q_{\rm int}>10{^{5}}$ over the entire tuning range. We demonstrate a tuning range of $> 3\%$ and tuning response times as short as 20 ns for the maximum achievable detuning. Due to the quasi-fractal design, the resonators are resilient to magnetic fields of up to 0.5 T

Impact of ambient odors on food intake, saliva production and appetite ratings

The aim of this study was to investigate the effect of ambient odor exposure on appetite, salivation and food intake. 32 normal-weight young women (age: 21.4\ua0\ub1\ua05.3\ua0year; BMI: 21.7\ua0\ub1\ua01.9\ua0kg/m2) attended five test sessions in a non-satiated state. Each participant was exposed to ambient odors (chocolate, beef, melon and cucumber), in a detectable but mild concentration, and to a control condition (no-odor exposure). During each condition, at different time points, participants rated appetite for 15 food products, and saliva was collected. After approximately 30\ua0min, ad libitum intake was measured providing a food (chocolate rice, high-energy dense product) that was congruent with one of the odors they were exposed to. A significant odor effect on food intake (p\ua0=\ua00.034) and salivation (p\ua0=\ua00.017) was found. Exposure to odors signaling high-energy dense products increased food intake (243.97\ua0\ub1\ua022.84\ua0g) compared to control condition (206.94\ua0\ub1\ua024.93\ua0g; p\ua0=\ua00.03). Consistently, salivation was increased significantly during chocolate and beef exposure (mean: 0.494\ua0\ub1\ua00.050\ua0g) compared to control condition (0.417\ua0\ub1\ua00.05\ua0g; p\ua0=\ua00.006). Even though odor exposure did not induce specific appetite for congruent products (p\ua0=\ua00.634), appetite scores were significantly higher during odor exposure (p\ua0<\ua00.0001) compared to the no-odor control condition and increased significantly over time (p\ua0=\ua00.010). Exposure to food odors seems to drive behavioral and physiological responses involved in eating behavior, specifically for odors and foods that are high in energy density. This could have implications for steering food intake and ultimately influencing the nutritional status of people

Superfluid vortex front at T -> 0: Decoupling from the reference frame

Steady-state turbulent motion is created in superfluid 3He-B at low temperatures in the form of a turbulent vortex front, which moves axially along a rotating cylindrical container of 3He-B and replaces vortex-free flow with vortex lines at constant density. We present the first measurements on the thermal signal from dissipation as a function of time, recorded at 0.2 Tc during the front motion, which is monitored using NMR techniques. Both the measurements and the numerical calculations of the vortex dynamics show that at low temperatures the density of the propagating vortices falls well below the equilibrium value, i.e. the superfluid rotates at a smaller angular velocity than the container. This is the first evidence for the decoupling of the superfluid from the container reference frame in the zero-temperature limit.Comment: 4 pages, 4 figure

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function

Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration. Here, we exploited a Rho GTPase-activating bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1), to interfere with glioma cell growth in vitro and vivo. We also investigated whether this toxin spares neuron structure and function in peritumoral areas. Methods. We performed a microarray transcriptomic and in-depth proteomic analysis to characterize the molecular changes triggered by CNF1 in glioma cells. We also examined tumor cell senescence and growth in vehicle-and CNF1-treated glioma-bearing mice. Electrophysiological and morphological techniques were used to investigate neuronal alterations in peritumoral cortical areas. Results. Administration of CNF1 triggered molecular and morphological hallmarks of senescence in mouse and human glioma cells in vitro. CNF1 treatment in vivo induced glioma cell senescence and potently reduced tumor volumes. In peritumoral areas of glioma-bearing mice, neurons showed a shrunken dendritic arbor and severe functional alterations such as increased spontaneous activity and reduced visual responsiveness. CNF1 treatment enhanced dendritic length and improved several physiological properties of pyramidal neurons, demonstrating functional preservation of the cortical network. Conclusions. Our findings demonstrate that CNF1 reduces glioma volume while at the same time maintaining the physiological and structural properties of peritumoral neurons. These data indicate a promising strategy for the development of more effective antiglioma therapies