2,201 research outputs found
Spatial Distribution of Competing Ions around DNA in Solution
The competition of monovalent and divalent cations for proximity to negatively charged DNA is of biological importance and can provide strong constraints for theoretical treatments of polyelectrolytes. Resonant x-ray scattering experiments have allowed us to monitor the number and distribution of each cation in a mixed ion cloud around DNA. These measurements provide experimental evidence to support a general theoretical prediction: the normalized distribution of each ion around polyelectrolytes remains constant when ions are mixed at different ratios. In addition, the amplitudes of the scattering signals throughout the competition provide a measurement of the surface concentration parameter that predicts the competition behavior of these cations. The data suggest that ion size needs to be taken into account in applying Poisson-Boltzmann treatments to polyelectrolytes such as DNA
Search For Trapped Antihydrogen
We present the results of an experiment to search for trapped antihydrogen
atoms with the ALPHA antihydrogen trap at the CERN Antiproton Decelerator.
Sensitive diagnostics of the temperatures, sizes, and densities of the trapped
antiproton and positron plasmas have been developed, which in turn permitted
development of techniques to precisely and reproducibly control the initial
experimental parameters. The use of a position-sensitive annihilation vertex
detector, together with the capability of controllably quenching the
superconducting magnetic minimum trap, enabled us to carry out a
high-sensitivity and low-background search for trapped synthesised antihydrogen
atoms. We aim to identify the annihilations of antihydrogen atoms held for at
least 130 ms in the trap before being released over ~30 ms. After a three-week
experimental run in 2009 involving mixing of 10^7 antiprotons with 1.3 10^9
positrons to produce 6 10^5 antihydrogen atoms, we have identified six
antiproton annihilation events that are consistent with the release of trapped
antihydrogen. The cosmic ray background, estimated to contribute 0.14 counts,
is incompatible with this observation at a significance of 5.6 sigma. Extensive
simulations predict that an alternative source of annihilations, the escape of
mirror-trapped antiprotons, is highly unlikely, though this possibility has not
yet been ruled out experimentally.Comment: 12 pages, 7 figure
Antihydrogen formation dynamics in a multipolar neutral anti-atom trap
Antihydrogen production in a neutral atom trap formed by an octupole-based
magnetic field minimum is demonstrated using field-ionization of weakly bound
anti-atoms. Using our unique annihilation imaging detector, we correlate
antihydrogen detection by imaging and by field-ionization for the first time.
We further establish how field-ionization causes radial redistribution of the
antiprotons during antihydrogen formation and use this effect for the first
simultaneous measurements of strongly and weakly bound antihydrogen atoms.
Distinguishing between these provides critical information needed in the
process of optimizing for trappable antihydrogen. These observations are of
crucial importance to the ultimate goal of performing CPT tests involving
antihydrogen, which likely depends upon trapping the anti-atom
Highly sensitive and broadband carbon nanotube radio-frequency single-electron transistor
We have investigated radio-frequency single-electron transistor (RF-SET)
operation of single-walled carbon nanotube quantum dots in the strong tunneling
regime. At 4.2 K and carrier frequency 754.2 MHz, we reach a charge sensitivity
of 2.3e-6 e/Hz^(1/2) over a bandwidth of 85 MHz. Our results indicate a
gain-bandwidth product of 3.7e13 Hz^(3/2)/e, which is by one order of magnitude
better than for typical RF-SETs.Comment: 4 pages, 3 figure
Highly sensitive and broadband carbon nanotube radio-frequency single-electron transistor
The Presampler for the Forward and Rear Calorimeter in the ZEUS Detector
The ZEUS detector at HERA has been supplemented with a presampler detector in
front of the forward and rear calorimeters. It consists of a segmented
scintillator array read out with wavelength-shifting fibers. We discuss its
desi gn, construction and performance. Test beam data obtained with a prototype
presampler and the ZEUS prototype calorimeter demonstrate the main function of
this detector, i.e. the correction for the energy lost by an electron
interacting in inactive material in front of the calorimeter.Comment: 20 pages including 16 figure
Production of antihydrogen at reduced magnetic field for anti-atom trapping
We have demonstrated production of antihydrogen in a 1T solenoidal
magnetic field. This field strength is significantly smaller than that used in
the first generation experiments ATHENA (3T) and ATRAP (5T). The
motivation for using a smaller magnetic field is to facilitate trapping of
antihydrogen atoms in a neutral atom trap surrounding the production region. We
report the results of measurements with the ALPHA (Antihydrogen Laser PHysics
Apparatus) device, which can capture and cool antiprotons at 3T, and then
mix the antiprotons with positrons at 1T. We infer antihydrogen production
from the time structure of antiproton annihilations during mixing, using mixing
with heated positrons as the null experiment, as demonstrated in ATHENA.
Implications for antihydrogen trapping are discussed
2-methylbutyryl-CoA dehydrogenase deficiency associated with autism and mental retardation: a case report
<p>Abstract</p> <p>Background</p> <p>2-methylbutyryl-CoA dehydrogenase deficiency or short/branched chain acyl-CoA dehydrogenase deficiency (SBCADD) is caused by a defect in the degradation pathway of the amino acid L-isoleucine.</p> <p>Methods</p> <p>We report a four-year-old mentally retarded Somali boy with autism and a history of seizures, who was found to excrete increased amounts of 2-methylbutyryl glycine in the urine. The SBCAD gene was examined with sequence analysis. His development was assessed with psychometric testing before and after a trial with low protein diet.</p> <p>Results</p> <p>We found homozygosity for A > G changing the +3 position of intron 3 (c.303+3A > G) in the SBCAD gene. Psychometric testing showed moderate mental retardation and behavioral scores within the autistic spectrum. No beneficial effect was detected after 5 months with a low protein diet.</p> <p>Conclusion</p> <p>This mutation was also found in two previously reported cases with SBCADD, both originating from Somalia and Eritrea, indicating that it is relatively prevalent in this population. Autism has not previously been described with mutations in this gene, thus expanding the clinical spectrum of SBCADD.</p
Influence of the 6^1S_0-6^3P_1 Resonance on Continuous Lyman-alpha Generation in Mercury
Continuous coherent radiation in the vacuum-ultraviolet at 122 nm
(Lyman-alpha) can be generated using sum-frequency mixing of three fundamental
laser beams in mercury vapour. One of the fundamental beams is at 254 nm
wavelength, which is close to the 6^1S_0-6^3P_1 resonance in mercury.
Experiments have been performed to investigate the effect of this one-photon
resonance on phasematching, absorption and the nonlinear yield. The efficiency
of continuous Lyman-alpha generation has been improved by a factor of 4.5.Comment: 8 pages, 7 figure
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