Nazi Medical Experimentation: Should the Data Obtained be Used?

Many researchers question whether or not the data obtained from Nazi medical experiments should be used. This paper examines which experiments were conducted, the data that was found, and the ethical questions related to using this data. Beyond the ethical questions, this paper also determines if the data can be used due to the way the experiments were conducted

The Study of the Pioneer Anomaly: New Data and Objectives for New Investigation

Radiometric tracking data from Pioneer 10 and 11 spacecraft has consistently indicated the presence of a small, anomalous, Doppler frequency drift, uniformly changing with a rate of ~6 x 10^{-9} Hz/s; the drift can be interpreted as a constant sunward acceleration of each particular spacecraft of a_P = (8.74 \pm 1.33) x 10^{-10} m/s^2. This signal is known as the Pioneer anomaly; the nature of this anomaly remains unexplained. We discuss the efforts to retrieve the entire data sets of the Pioneer 10/11 radiometric Doppler data. We also report on the recently recovered telemetry files that may be used to reconstruct the engineering history of both spacecraft using original project documentation and newly developed software tools. We discuss possible ways to further investigate the discovered effect using these telemetry files in conjunction with the analysis of the much extended Doppler data. We present the main objectives of new upcoming study of the Pioneer anomaly, namely i) analysis of the early data that could yield the direction of the anomaly, ii) analysis of planetary encounters, that should tell more about the onset of the anomaly, iii) analysis of the entire dataset, to better determine the anomaly's temporal behavior, iv) comparative analysis of individual anomalous accelerations for the two Pioneers, v) the detailed study of on-board systematics, and vi) development of a thermal-electric-dynamical model using on-board telemetry. The outlined strategy may allow for a higher accuracy solution for a_P and, possibly, will lead to an unambiguous determination of the origin of the Pioneer anomaly.Comment: 43 pages, 40 figures, 3 tables, minor changes before publicatio

Determination of Adrenal Response After Oral Administration of Multiple Doses of Methylprednisolone

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97189/1/j.1552-4604.1979.tb01627.x.pd

Rectal and oral absorption of methylprednisolone acetate

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117227/1/cpt1979262232.pd

August 1972 solar-terrestrial events: Observations of interplanetary shocks at 2.2 AU

Pioneer 10 magnetic field measurements, supplemented by previously published plasma data, have been used to identify shocks at 2.2 AU associated with the large solar flares of early August 1972. The first three flares, which gave rise to three forward shocks at Pioneer 9 and at earth, led to only a single forward shock at Pioneer 10. The plasma driver accompanying the shock has been tentatively identified. A local shock velocity at Pioneer 10 of 717 km/s has been estimated by assuming that the shock was propagating radially across the interplanetary magnetic field. This velocity and the rise time of ≃2 s imply a shock thickness of ∼1400 km, which appears to be large in comparison with the characteristic plasma lengths customarily used to account for the thickness of the earth's bow shock. This Pioneer 10 shock is identified with the second forward shock observed at Pioneer 9, which was then at 0.8 AU and radially aligned with Pioneer 10, since it was apparently the only Pioneer 9 shock that was also driven. The local velocity of the Pioneer 9 shock of 670 km/s, previously inferred by other authors, compares reasonably well with the local velocity at Pioneer 10, but both values are significantly smaller than the average value computed from the time interval required for the shock to propagate from the sun to Pioneer 9 (2220 km/s). The velocity implied by the time required to propagate from Pioneer 9 to Pioneer 10 (770 km/s) is in reasonable agreement with the local velocities. The fourth solar flare also gave rise to a forward shock at Pioneer 10 as well as at Pioneer 9. The local velocity at Pioneer 10, estimated on the basis of quasi-perpendicularity, is 660 km/s, a value which again agrees well with previously derived velocities for the Pioneer 9 shock of 670 km/s. The local velocities for this shock and the velocity between Pioneer 9 and Pioneer 10 (635 km/s) are also significantly less than the average velocity of propagation from the sun to Pioneer 9 (830 km/s). The general finding that the local velocities of both shocks are approximately equal at 0.8 and 2.2 AU but significantly slower than the average speeds nearer the sun is interpreted as evidence of a major deceleration of the shocks as they propagate outward from the sun that is essentially completed when the shocks reach 0.8 AU, there being little, if any, subsequent deceleration. This conclusion is qualitatively inconsistent with previous inferences of a deceleration of the shocks as they propagate from 0.8 to 2.2 AU. A third, reverse shock is also identified in the Pioneer 10 data which was not seen either at Pioneer 9 or at earth. The estimated speed of this shock is 530 km/s, and its estimated thickness is ≲500 km, which compares well with an anticipated proton inertial length of 500 km

A genomic survey of the fish parasite Spironucleus salmonicida indicates genomic plasticity among diplomonads and significant lateral gene transfer in eukaryote genome evolution

BACKGROUND: Comparative genomic studies of the mitochondrion-lacking protist group Diplomonadida (diplomonads) has been lacking, although Giardia lamblia has been intensively studied. We have performed a sequence survey project resulting in 2341 expressed sequence tags (EST) corresponding to 853 unique clones, 5275 genome survey sequences (GSS), and eleven finished contigs from the diplomonad fish parasite Spironucleus salmonicida (previously described as S. barkhanus). RESULTS: The analyses revealed a compact genome with few, if any, introns and very short 3' untranslated regions. Strikingly different patterns of codon usage were observed in genes corresponding to frequently sampled ESTs versus genes poorly sampled, indicating that translational selection is influencing the codon usage of highly expressed genes. Rigorous phylogenomic analyses identified 84 genes – mostly encoding metabolic proteins – that have been acquired by diplomonads or their relatively close ancestors via lateral gene transfer (LGT). Although most acquisitions were from prokaryotes, more than a dozen represent likely transfers of genes between eukaryotic lineages. Many genes that provide novel insights into the genetic basis of the biology and pathogenicity of this parasitic protist were identified including 149 that putatively encode variant-surface cysteine-rich proteins which are candidate virulence factors. A number of genomic properties that distinguish S. salmonicida from its human parasitic relative G. lamblia were identified such as nineteen putative lineage-specific gene acquisitions, distinct mutational biases and codon usage and distinct polyadenylation signals. CONCLUSION: Our results highlight the power of comparative genomic studies to yield insights into the biology of parasitic protists and the evolution of their genomes, and suggest that genetic exchange between distantly-related protist lineages may be occurring at an appreciable rate in eukaryote genome evolution

Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix

The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC‐derived epithelial progenitor cells. The iPSCs‐derived epithelial progenitor cells lined the decellularized human lung and expressed most of the epithelial markers when were cultured in a lung bioreactor system. In decellularized rat lungs, these human‐derived cells attach and proliferate in a manner similar to what was observed in the decellularized human lung. Our results suggest that repopulation of lung matrix with iPSC‐derived lung epithelial cells may be a viable strategy for human lung regeneration and represents an important early step toward translation of this technology.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/1/term2589.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/2/term2589_am.pd

Saturn's Magnetic Field and Magnetosphere

The Pioneer Saturn vector helium magnetometer has detected a bow shock and magnetopause at Saturn and has provided an accurate characterization of the planetary field. The equatorial surface field is 0.20 gauss, a factor of 3 to 5 times smaller than anticipated on the basis of attempted scalings from Earth and Jupiter. The tilt angle between the magnetic dipole axis and Saturn's rotation axis is < 1°, a surprisingly small value. Spherical harmonic analysis of the measurements shows that the ratio of quadrupole to dipole moments is < 10 percent, indicating that the field is more uniform than those of the Earth or Jupiter and consistent with Saturn having a relatively small core. The field in the outer magnetosphere shows systematic departures from the dipole field, principally a compression of the field near noon and an equatorial orientation associated with a current sheet near dawn. A hydromagnetic wake resulting from the interaction of Titan with the rotating magnetosphere appears to have been observed

Impact of technology-based interventions for children and young people with type 1 diabetes on key diabetes self-management behaviours and prerequisites: A systematic review

Background The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behaviours (self-management of blood glucose, insulin administration, physical activity and dietary behaviours) and prerequisites (psychological outcomes and HbA1c) highlighted in the UK guidelines of the National Institute for Health and Care Excellence (NICE) for management of T1DM. The purpose was to identify evidence to assess the effectiveness of technological tools in promoting aspects of these guidelines amongst children and young people. Methods A systematic review of English language articles was conducted using the following databases: Web of Science, PubMed, Scopus, NUSearch, SAGE Journals, SpringerLink, Google Scholar, Science Direct, Sport Discus, Embase, Psychinfo and Cochrane Trials. Search terms included paediatric, type one diabetes, technology, intervention and various synonyms. Included studies examined interventions which supplemented usual care with a health care strategy primarily delivered through a technology-based medium (e.g. mobile phone, website, activity monitor) with the aim of engaging children and young people with T1DM directly in their diabetes healthcare. Studies did not need to include a comparator condition and could be randomised, non-randomised or cohort studies but not single-case studies. Results Of 30 included studies (21 RCTs), the majority measured self-monitoring of blood glucose monitoring (SMBG) frequency, clinical indicators of diabetes self-management (e.g. HbA1c) and/or psychological or cognitive outcomes. The most positive findings were associated with technology-based health interventions targeting SMBG as a behavioural outcome, with some benefits found for clinical and/or psychological diabetes self-management outcomes. Technological interventions were well accepted by children and young people. For the majority of included outcomes, clinical relevance was deemed to be little or none. Conclusions More research is required to assess which elements of interventions are most likely to produce beneficial behavioural outcomes. To produce clinically relevant outcomes, interventions may need to be delivered for at least 1 year and should consider targeting individuals with poorly managed diabetes. It is not possible to determine the impact of technology-based interventions on insulin administration, dietary habits and/or physical activity behaviour due to lack of evidence