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Cyclic AMP modulation of ion transport across frog retinal pigment epithelium. Measurements in the short-circuit state.
In the frog retinal pigment epithelium (RPE), the cellular levels of cyclic AMP (cAMP) were measured in control conditions and after treatment with substances that are known to inhibit phosphodiesterase (PDE) activity (isobutyl-1-methylxanthine, SQ65442) or stimulate adenylate cyclase activity (forskolin). The cAMP levels were elevated by a factor of 5-7 compared with the controls in PDE-treated tissues and by a factor of 18 in forskolin-treated tissues. The exogenous application of cAMP (1 mM), PDE inhibitors (0.5 mM), or forskolin (0.1 mM) all produced similar changes in epithelial electrical parameters, such as transepithelial potential (TEP) and resistance (Rt), as well as changes in active ion transport. Adding 1 mM cAMP to the solution bathing the apical membrane transiently increased the short-circuit current (SCC) and the TEP (apical side positive) and decreased Rt. Microelectrode experiments showed that the elevation in TEP is due mainly to a depolarization of the basal membrane followed by, and perhaps also accompanied by, a smaller hyperpolarization of the apical membrane. The ratio of the apical to the basolateral membrane resistance increased in the presence of cAMP, and this increase, coupled with the decrease in Rt and the basolateral membrane depolarization, is consistent with a conductance increase at the basolateral membrane. Radioactive tracer experiments showed that cAMP increased the active secretion of Na (choroid to retina) and the active absorption of K (retina to choroid). Cyclic AMP also abolished the active absorption of Cl across the RPE. In sum, elevated cellular levels of cAMP affect active and passive transport mechanisms at the apical and basolateral membranes of the bullfrog RPE
Conditions driving chemical freeze-out
We propose the entropy density as the thermodynamic condition driving best
the chemical freeze-out in heavy-ion collisions. Taking its value from lattice
calculations at zero chemical potential, we find that it is excellent in
reproducing the experimentally estimated freeze-out parameters. The two
characteristic endpoints in the freeze-out diagram are reproduced as well.Comment: 8 pages, 5 eps figure
The Highly Oscillatory Behavior of Automorphic Distributions for SL(2)
Automorphic distributions for SL(2) arise as boundary values of modular forms
and, in a more subtle manner, from Maass forms. In the case of modular forms of
weight one or of Maass forms, the automorphic distributions have continuous
first antiderivatives. We recall earlier results of one of us on the Holder
continuity of these continuous functions and relate them to results of other
authors; this involves a generalization of classical theorems on Fourier series
by S. Bernstein and Hardy-Littlewood. We then show that the antiderivatives are
non-differentiable at all irrational points, as well as all, or in certain
cases, some rational points. We include graphs of several of these functions,
which clearly display a high degree of oscillation. Our investigations are
motivated in part by properties of "Riemann's nondifferentiable function", also
known as "Weierstrass' function".Comment: 27 pages, 6 Figures; version 2 corrects misprints and updates
reference
Noise predictions and economic effects of Boeing nacelle modifications
Noise level predictions and economics of Boeing nacelle modification
The influence of strange quarks on QCD phase diagram and chemical freeze-out: Results from the hadron resonance gas model
We confront the lattice results on QCD phase diagram for two and three
flavors with the hadron resonance gas model. Taking into account the
truncations in the Taylor-expansion of energy density done on the
lattice at finite chemical potential , we find that the hadron resonance
gas model under the condition of constant describes very well the
lattice phase diagram. We also calculate the chemical freeze-out curve
according to the entropy density . The -values are taken from lattice QCD
simulations with two and three flavors. We find that this condition is
excellent in reproducing the experimentally estimated parameters of the
chemical freeze-out.Comment: 5 pages, 3 figures and 1 table Talk given at VIIIth international
conference on ''Strangeness in Quark Matter'' (SQM 2004), Cape Town, South
Africa, Sep. 15-20 200
Experimental investigation of leading-edge thrust at supersonic speeds
Wings, designed for leading edge thrust at supersonic speeds, were investigated in the Unitary Plan Wind Tunnel at Mach numbers of 1.60, 1.80, 2.00, 2.16, and 2.36. Experimental data were obtained on a uncambered wing which had three interchangeable leading edges that varied from sharp to blunt. The leading edge thrust concept was evaluated. Results from the investigation showed that leading edge flow separation characteristics of all wings tested agree well with theoretical predictions. The experimental data showed that significant changes in wing leading edge bluntness did not affect the zero lift drag of the uncambered wings
<theoretical studies on the relationships be- tween the thermionic work function of refrac- tory intermetallic compounds and their electronic and crystal structures< progress report, 1 jan. - 30 jun. 1965
Thermionic work function of refractory intermetallic compounds and their electronic and crystal structure
Formulation and evaluation of C-Ether fluids as lubricants useful to 260 C
Three base stocks were evaluated in bench and bearing tests to determine their suitability for use at bulk oil temperatures (BOT) from -40 C to +260 C. A polyol ester gave good bearing tests at a bulk temperature of 218 C, but only a partially successful run at 274 C. These results bracket the fluid's maximum operating temperature between these values. An extensive screening program selected lubrication additives for a C-ether (modified polyphenyl ether) base stock. One formulation lubricated a bearing for 111 hours at 274 C (BOT), but this fluid gave many deposit related problems. Other C-ether blends produced cage wear or fatigue failures. Studies of a third fluid, a C-ether/disiloxane blend, consisted of bench oxidation and lubrication tests. These showed that some additives react differently in the blend than in pure C-ethers
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