Beam Coupling Impedance Contribution of Flange Aperture Gaps: A Numerical Study for Elettra 2.0

The accurate analysis of any possible source of beam instability is mandatory for the design of a new particle accelerator, especially for high-current and ultra-low emittance synchrotrons. In the specific case of instabilities driven by the coupling between the charged particle beam and the electromagnetic field excited by the beam itself, the corresponding effect is estimated through the beam coupling impedance. The modeling of this effect is essential to perform a rigorous evaluation of the coupling impedance budget able to account for all devices present in the entire machine. To deal with this problem, this paper focuses on the estimation of the contribution of the joints lying between the different vacuum chamber sections, by performing a comparative numerical analysis that takes into account different aperture gaps between the flanges. The results point out the criticality of many small-impedance contributions that, added together, must be lower than a predefined impedance threshold

Interpreting Crab Nebula’s synchrotron spectrum: two acceleration mechanisms

We outline a model of the Crab pulsar wind nebula with two different populations of synchrotron emitting particles, arising from two different acceleration mechanisms: (i) Component-I due to Fermi-I acceleration at the equatorial portion of the termination shock, with particle spectral index pI ≈ 2.2 above the injection break corresponding to γwindσwind ∼ 105, peaking in the ultraviolet (UV, γwind ∼ 102 is the bulk Lorentz factor of the wind, σwind ∼ 103 is wind magnetization); and (ii) Component-II due to acceleration at reconnection layers in the bulk of the turbulent Nebula, with particle index pII ≈ 1.6. The model requires relatively slow but highly magnetized wind. For both components, the overall cooling break is in the infrared at ∼0.01 eV, so that the Component-I is in the fast cooling regime (cooling frequency below the peak frequency). In the optical band, Component-I produces emission with the cooling spectral index of αo ≈ 0.5, softening towards the edges due to radiative losses. Above the cooling break, in the optical, UV, and X-rays, Component-I mostly overwhelms Component-II. We hypothesize that acceleration at large-scale current sheets in the turbulent nebula (Component-II) extends to the synchrotron burn-off limit of ϵs ∼ 100 MeV. Thus in our model acceleration in turbulent reconnection (Component-II) can produce both hard radio spectra and occasional gamma-ray flares. This model may be applicable to a broader class of high-energy astrophysical objects, like active galactic nuclei and gamma-ray burst jets, where often radio electrons form a different population from the high-energy electrons

OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness

OCT4 (Octamer-binding transcription factor 4) is essential for embryonic stem cell self-renewal. Here we show that OCT4 increases the aggressiveness of high-grade serous ovarian cancer (HG-SOC) by inactivating the Retinoblastoma tumor suppressor pathway and enhancing mitotic stability in cancer cells. OCT4 drives the expression of Nuclear Inhibitor of Protein Phosphatase type 1 (NIPP1) and Cyclin F (CCNF) that together inhibit Protein Phosphatase 1 (PP1). This results in pRB hyper-phosphorylation, accelerated cell proliferation and increased in vitro tumorigenicity of ovarian cancer cells. In parallel, OCT4 and NIPP1/CCNF drive the expression of the central Chromosomal Passenger Complex (CPC) components, Borealin, Survivin and the mitotic kinase Aurora B, promoting the clustering of supernumerary centrosomes to increase mitotic stability. Loss of OCT4 or NIPP1/CCNF results in severe mitotic defects, multipolar spindles and supernumerary centrosomes, finally leading to the induction of apoptosis. These phenotypes were recapitulated in different cancer models indicating general relevance for human cancer. Importantly, activation of these parallel pathways leads to dramatically reduced overall survival of HG-SOC patients. Altogether, our data highlights an unprecedented role for OCT4 as central regulator of mitotic fidelity and RB tumor suppressor pathway activity. Disrupting this pathway represents a promising strategy to target an aggressive subpopulation of HG-SOC cells.Oncogene advance online publication, 20 March 2017; doi:10.1038/onc.2017.20

A Simple Blass Matrix Design Strategy for Multibeam Arbitrary Linear Antenna Arrays

Multibeam antenna arrays are currently recognized as one of the enabling technologies for the next-generation communication standards. One of the key components of these systems is the beamforming network (BFN) that implements the array element excitations. This article addresses this issue by presenting a novel strategy to realize an analog feeding network, which allows an arbitrary linear array (LA) to radiate multiple arbitrary beams. In particular, an iterative procedure is conceived to design a Blass matrix using an identical directional coupler for all nodes, resulting in a very simple structure suitable for large-scale production. Two applications with arbitrary directions are illustrated as proofs-of-concept for the developed architecture: a dual-beam configuration with a null involving an aperiodic LA, and a four-beam configuration involving a periodic LA. For this second application, the effectiveness of the proposed solution is further verified by full-wave simulations and experimental measurements carried out on a fabricated prototype

Fine-tuning the electrostatic properties of an alkali-linked organic adlayer on a metal substrate

The performance of modern organic electronic devices is often determined by the electronic level alignment at a metal–organic interface. This property can be controlled by introducing an interfacial electrostatic dipole via the insertion of a stable interlayer between the metallic and the organic phases. Here, we use density functional theory to investigate the electrostatic properties of an assembled structure formed by alkali metals coadsorbed with 7,7,8,8-tetracyanoquinodimethane (TCNQ) molecules on a Ag(100) substrate. We find that the interfacial dipole buildup is regulated by the interplay of adsorption energetics, steric constraints and charge transfer effects, so that choosing chemical substitutions within TCNQ and different alkali metals provides a rich playground to control the systems’ electrostatics and in particular fine-tune its work-function shift

The new MMT

ABSTRACT Originally commissioned in 1979, the Multiple Mirror Telescope was a highly innovative and successful facility that pioneered many of the technologies that are used in the new generation of 8 to 10 m class telescopes. After 19 years of operations the MMT was decommissioned in March of 1998: the enclosure was modified, the optics support structure was replaced, and a single 6.5-meter primary mirror was installed and aluminized in-situ. First light for the new MMT was celebrated on May 13, 2000. Operations began with an f/9 optical configuration compatible with existing instruments. Work has continued commissioning two new optical configurations that will serve a suite of new instruments: an f/15 deformable secondary mirror and adaptive optics facility that has obtained diffraction-limited images; and an f/5.4 secondary mirror and refractive corrector that provides a one-degree diameter field of view. The wide-field instrument suite includes two fiber-fed bench spectrographs, a robotic fiber positioner, and a wide-field imaging camera