276 research outputs found
By the Way - The Equal Protection Clause Has Always Protected a Class-of-One: An Examination of Village of Willowbrook v. Olech
A reduced semantics for deciding trace equivalence using constraint systems
Many privacy-type properties of security protocols can be modelled using
trace equivalence properties in suitable process algebras. It has been shown
that such properties can be decided for interesting classes of finite processes
(i.e., without replication) by means of symbolic execution and constraint
solving. However, this does not suffice to obtain practical tools. Current
prototypes suffer from a classical combinatorial explosion problem caused by
the exploration of many interleavings in the behaviour of processes.
M\"odersheim et al. have tackled this problem for reachability properties using
partial order reduction techniques. We revisit their work, generalize it and
adapt it for equivalence checking. We obtain an optimization in the form of a
reduced symbolic semantics that eliminates redundant interleavings on the fly.Comment: Accepted for publication at POST'1
Physical inactivity amplifies the negative association between sleep quality and depressive symptoms.
Poor sleep quality and physical inactivity are known risk factors for depressive symptoms. Yet, whether these factors differently contribute to depressive symptoms and whether they interact with one another remains unclear. Here, we examined how sleep quality and physical activity influence depressive symptoms in 79,274 adults 50 years of age or older (52.4% women) from the Survey of Health, Aging and Retirement in Europe (SHARE) study. Sleep quality (poor vs. good), physical activity (inactive vs. active), and depressive symptoms (0 to 12 score) were repeatedly collected (7 waves of data collection) between 2004 and 2017. Results showed that sleep quality and physical activity were associated with depressive symptoms. Specifically, participants with poorer sleep quality reported more depressive symptoms than participants with better sleep quality (b = 1.85, 95% CI = 1.83-1.86, p < .001). Likewise, compared to physically active participants, physically inactive participants reported more depressive symptoms (b = 0.44, 95% CI = 0.42-0.45, p < .001). Moreover, sleep quality and physical activity showed an interactive association with depressive symptoms (b = 0.17, 95% CI = 0.13-0.20, p < .001). The negative association between poor sleep quality and higher depressive symptoms was stronger in physically inactive than active participants. These findings suggest that, in adults 50 years of age or older, both poor sleep quality and physical inactivity are related to an increase in depressive symptoms. Moreover, the detrimental association between poor sleep quality and depressive symptoms is amplified in physically inactive individuals
Empresas, periódicos y periodistas en las autonomías
Esta artículo de investigacion se centra en las empresas de prensa regional y en los periodistas de las Autonomias españolas. Desde que el Estado Español se configuró como un Estado Autonómico de diecisiete comunidades Autónomas a partir de la Constitucion de 1978, la importancias de la prensa regional ha aumentado año tras año. Nuestro trabajo parte de una entrevista en profundiad a los directores y consejeros delegados de catorce periódicos regionales, que representan en torno al 20% de la difusión y del capital de la prensa en España. El objetivo de la investigación es un conocimiento profundo de la prensa regional: orientación ideológica e intereses, su evolución economica, ingresos (por venta al numero y publicidad), beneficios y cash-flow; la organizacion del trabajo de edición; la formación de los periodistas, edad, sexo, afilicación sindical, etc; y también, un breve analisis de su contenido (primera página, secciones, fuentes, importancia de la fotografía, infografía y color), etc
Cognitive-bias modification intervention to improve physical activity in patients following a rehabilitation programme:protocol for the randomised controlled IMPACT trial
The hitchhiker's guide to decidability and complexity of equivalence properties in security protocols
International audiencePrivacy-preserving security properties in cryptographic protocols are typically modelled by observational equivalences in process calculi such as the applied pi-calulus. We survey decidability and complexity results for the automated verification of such equivalences, casting existing results in a common framework which allows for a precise comparison. This unified view, beyond providing a clearer insight on the current state of the art, allowed us to identify some variations in the statements of the decision problems-sometimes resulting in different complexity results. Additionally, we prove a couple of novel or strengthened results
Expression Profile of Nuclear Receptors along Male Mouse Nephron Segments Reveals a Link between ERRβ and Thick Ascending Limb Function
The nuclear receptor family orchestrates many functions related to reproduction, development, metabolism, and adaptation to the circadian cycle. The majority of these receptors are expressed in the kidney, but their exact quantitative localization in this ultrastructured organ remains poorly described, making it difficult to elucidate the renal function of these receptors. In this report, using quantitative PCR on microdissected mouse renal tubules, we established a detailed quantitative expression map of nuclear receptors along the nephron. This map can serve to identify nuclear receptors with specific localization. Thus, we unexpectedly found that the estrogen-related receptor β (ERRβ) is expressed predominantly in the thick ascending limb (TAL) and, to a much lesser extent, in the distal convoluted tubules. In vivo treatment with an ERR inverse agonist (diethylstilbestrol) showed a link between this receptor family and the expression of the Na+,K+-2Cl− cotransporter type 2 (NKCC2), and resulted in phenotype presenting some similarities with the Bartter syndrom (hypokalemia, urinary Na+ loss and volume contraction). Conversely, stimulation of ERRβ with a selective agonist (GSK4716) in a TAL cell line stimulated NKCC2 expression. All together, these results provide broad information regarding the renal expression of all members of the nuclear receptor family and have allowed us to identify a new regulator of ion transport in the TAL segments
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