13,105 research outputs found

    PIH20 CONJOINT-ANALYSIS QALYS FOR ACUTE CONDITIONS

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    AR3 CAUSES AND EFFECTS OF SCENARIO REJECTION: STATED PREFERENCES FOR RHEUMATOID ARTHRITIS TREATMENTS

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    Dynamical age differences among coeval star clusters as revealed by blue stragglers

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    Globular star clusters that formed at the same cosmic time may have evolved rather differently from a dynamical point of view (because that evolution depends on the internal environment) through a variety of processes that tend progressively to segregate stars more massive than the average towards the cluster centre. Therefore clusters with the same chronological age may have reached quite different stages of their dynamical history (that is, they may have different dynamical ages). Blue straggler stars have masses greater than those at the turn-off point on the main sequence and therefore must be the result of either a collision or a mass-transfer event. Because they are among the most massive and luminous objects in old clusters, they can be used as test particles with which to probe dynamical evolution. Here we report that globular clusters can be grouped into a few distinct families on the basis of the radial distribution of blue stragglers. This grouping corresponds well to an effective ranking of the dynamical stage reached by stellar systems, thereby permitting a direct measure of the cluster dynamical age purely from observed properties.Comment: Published on the 20 December 2012 issue of Natur

    PMS67 TWO YEAR MAINTENANCE INFLIXIMAB DOSING AND ADMINISTRATION PATTERNS IN PATIENTS WITH RHEUMATOID ARTHRITIS

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    The double blue-straggler sequence in NGC 2173: an artifact of field contamination

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    Here we discuss the case of the double blue straggler star (BSS) sequence recently detected in the young stellar cluster NGC2173 in the Large Magellanic Cloud (LMC) by Li et al. (2018, ApJ, 856, 25). In order to investigate this feature we made use of two Hubble Space Telescope (HST) sets of observations, one (the same one used by Li et al.) probing the cluster central regions, and the other sampling the surrounding field. We demonstrate that when field star decontamination is applied, _40% of the BSS population selected by Li et al. turns out to be composed of field stars interlopers. This contamination mainly affects one of the two sequences, which therefore disappears in the decontaminated color-magnitude diagram. We analyze the result of tens different decontamination realizations: we find no evidence of a double BSS sequence in any of them. We therefore conclude that NGC2173 harbors a normal single (poorly populated) BSS sequence and that particular care needs to be devoted to the field decontamination process in any study aimed at probing stellar population features or star counts in the LMC clusters

    Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features

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    Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor α (ERα) estrogen receptor β (ERβ), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor γ (PPARγ) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPARγ, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ERα, ERβ, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health
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