Linear optics implementation of weak values in Hardy's paradox

We propose an experimental setup for the implementation of weak measurements in the context of the gedankenexperiment known as Hardy's Paradox. As Aharonov et al. showed, these weak values form a language with which the paradox can be resolved. Our analysis shows that this language is indeed consistent and experimentally testable. It also reveals exactly how a combination of weak values can give rise to an apparently paradoxical result.Comment: 4 pages, accepted by PR

Reply to "Comment on 'A linear optics implementation of weak values in Hardy's paradox'"

The comment by Lundeen et al. contains two criticisms of our proposal. While we agree that the state-preparation procedure could be replaced by a simpler setup as proposed by the authors of the comment, we do not agree with the authors on their second, and more important point regarding two-particle weak measurements. We believe this to be the result of a misunderstanding of our original paper.Comment: 2 pages, accepted in PR

Minimal requirements for exocytosis

The membrane-permeabilizing effects of streptolysin O, staphylococcal alpha-toxin, and digitonin on cultured rat pheochromocytoma cells were studied. All three agents perturbed the plasma membrane, causing release of intracellular 86Rb+ and uptake of trypan blue. In addition, streptolysin O and digitonin also damaged the membranes of secretory vesicles, including a parallel release of dopamine. In contrast, the effects of alpha-toxin appeared to be strictly confined to the plasma membrane, and no dopamine release was observed with this agent. The exocytotic machinery, however, remained intact and could be triggered by subsequent introduction of micromolar concentrations of Ca2+ into the medium. Dopamine release was entirely Ca2+ specific and occurred independent of the presence or absence of other cations or anions including K+ glutamate, K+ acetate, or Na+ chloride. Ca2+-induced exocytosis did not require the presence of Mg2+-ATP in the medium. The process was insensitive to pH alterations in the range pH 6.6-7.2, and appeared optimal at an osmolarity of 300 mosm/kg. Toxin permeabilization seems to be an excellent method for studying the minimal requirements for exocytosis

A Community Under Attack: Protestant Letter Networks in the Reign of Mary I

This is a manuscript version of the article which has been accepted for publication in Leonardo. The final published version can be found here: http://dx.doi.org/10.1162/LEON_a_00778This article uses mathematical and computational techniques to reconstruct and analyze the social and textual organization of the underground community of Protestants living in England during the reign of Mary I from 289 surviving letters. © 2014 ISAST

Nondeterministic self-assembly of two tile types on a lattice.

Self-assembly is ubiquitous in nature, particularly in biology, where it underlies the formation of protein quaternary structure and protein aggregation. Quaternary structure assembles deterministically and performs a wide range of important functions in the cell, whereas protein aggregation is the hallmark of a number of diseases and represents a nondeterministic self-assembly process. Here we build on previous work on a lattice model of deterministic self-assembly to investigate nondeterministic self-assembly of single lattice tiles and mixtures of two tiles at varying relative concentrations. Despite limiting the simplicity of the model to two interface types, which results in 13 topologically distinct single tiles and 106 topologically distinct sets of two tiles, we observe a wide variety of concentration-dependent behaviors. Several two-tile sets display critical behaviors in the form of a sharp transition from bound to unbound structures as the relative concentration of one tile to another increases. Other sets exhibit gradual monotonic changes in structural density, or nonmonotonic changes, while again others show no concentration dependence at all. We catalog this extensive range of behaviors and present a model that provides a reasonably good estimate of the critical concentrations for a subset of the critical transitions. In addition, we show that the structures resulting from these tile sets are fractal, with one of two different fractal dimensions.This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by the American Physical Society

Metadata, surveillance, and the Tudor State

In 2013 the whistleblower Edward Snowden revealed a surveillance programme called PRISM, within which the United States National Security Agency (NSA) had accessed and analysed the metadata from phone calls, emails, and other digital data stored by Verizon and nine internet companies. This article seeks to show that surprisingly deep insights can be gleaned from metadata by applying a range of easily available network-analysis algorithms to a body of metadata generated by another government. The source is the British State Papers (now digitized at State Papers Online), which contain 132,747 unique letters from the period between the accession of Henry VIII and the death of Elizabeth I. An analysis of this archive shows us that we can observe not only broad patterns of communication but also anomalous behaviour, and can make predictions about people likely to be trading in conspiracies or illicit intelligence. These discoveries demonstrate the power of such methods for the study of history. This power, however, is merely a shadow of that wielded by government bodies and private companies and therefore the findings also act as a warning about the potential uses and abuses of the metadata we generate with each of our digital communications

GTP and Ca2+ Modulate the Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Release in Streptolysin O-Permeabilized Bovine Adrenal Chromaffin Cells

The inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release was studied using streptolysin O-permeabilized bovine adrenal chromaffin cells. The IP3-induced Ca2+ release was followed by Ca2+ reuptake into intracellular compartments. The IP3-induced Ca2+ release diminished after sequential applications of the same amount of IP3. Addition of 20 μM GTP fully restored the sensitivity to IP3. Guanosine 5'-O-(3-thio)triphosphate (GTPγS) could not replace GTP but prevented the action of GTP. The effects of GTP and GTPγS were reversible. Neither GTP nor GTPγS induced release of Ca2+ in the absence of IP3. The amount of Ca2+ whose release was induced by IP3 depended on the free Ca2+ concentration of the medium. At 0.3 μM free Ca2+, a half-maximal Ca2+ release was elicited with ∼0.1 μM IP3. At 1 μM free Ca2+, no Ca2+ release was observed with 0.1 μM IP3; at this Ca2+ concentration, higher concentrations of IP3 (0.25 μM) were required to evoke Ca2+ release. At 8 μM free Ca2+, even 0.25 μM IP3 failed to induce release of Ca2+ from the store. The IP3-induced Ca2+ release at constant low (0.2 μM) free Ca2+ concentrations correlated directly with the amount of stored Ca2+. Depending on the filling state of the intracellular compartment, 1 mol of IP3 induced release of between 5 and 30 mol of Ca2+