Ovarian malignant mixed germ cell tumor: A case of unusual presentation as molar pregnancy

Background: This research was conducted to introduce a patient with rare ovarian mixed germ cell tumor, presented as molar pregnancy. Case Presentation: The patient was a 16 year old woman admitted with diagnosis of molar pregnancy. Abdominal enlargement was the only complaint. She had a large pelvic mass in physical examination. The first diagnosis was molar pregnancy due to previous ultrasonic reports and positive βeta HCG. Urine pregnancy test was positive. As suction curettage was performed for her, surprisingly, the size of uterus was normal and no molar tissue was found in pathologic examination. At intraoperative ultrasound exam, an extra-uterine heterogeneous mass was found. Extra-uterine mass was confirmed by CT and MRI done after suction curettage. Mixed germ cell tumor was confirmed by histological examination after laparatomy and removing tumoral mass. Finally, she received Bleomycin, Etoposide and Cisplatin (BEP) regimen in four courses and Vincristine, Actinomycin D (Dactinomycin) and Cyclophosphamide (VAC) regimen in two courses and Diphereline for saving the other ovary. Conclusion: Some young patients misinterpret the early symptoms of an ovarian neoplasm as those of pregnancy which can lead to a delay in the diagnosis

Serum biochemical and histopathological changes in liver and kidney in lambs after zinc oxide nanoparticles administration

Background: Zinc is an essential co-factor for many enzymatic activities and its deficiency may produce clinical signs of parakeratosis, loss and failure of growth of wool and hair in sheep. Aim: The present study was designed to evaluate the effect of zinc oxide nano-particles (instead conventional zinc oxide) on serum biochemical factors and histopathological changes in liver and kidney of lambs. Materials and Methods: One group of lamb (4 lambs each group) received zinc oxide nano-particles suspension daily for 25 day. Whole blood sample and serum were collected at the start and the end of study. Activities of lactate dehydrogenase (LDH), alanine aminotransferas (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN), and creatinine (CR) were measured in serum of lambs. Sections of liver and kidney were stained with hematoxylin-eosin and examined by light microscopy. Results: Activity of ALP (p=0.011) was significantly decreased and creatinine level (p=0.002) was significantly increased by zinc oxide nano-particles. Cell swelling, eosinophilic necrosis of hepatocytes, and multifocal interstitial nephritis was observed during histopatological examination. Conclusion: Results of study suggest that zinc oxide nano-particles may be toxic for use in sheep in zinc deficiency status. [Vet World 2013; 6(8.000): 534-537