Stress-Mediated cis-Element Transcription Factor Interactions Interconnecting Primary and Specialized Metabolism in planta

Plant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come through primary metabolism, extensive investigations have been carried out to understand the detailed connection between primary and specialized metabolism at various levels. Stress regulates the expression of primary and specialized metabolism genes at the transcriptional level via transcription factors binding to specific cis-elements. The presence of varied cis-element signatures upstream to different stress-responsive genes and their transcription factor binding patterns provide a prospective molecular link among diverse metabolic pathways. The pattern of occurrence of these cis-elements (overrepresentation/common) decipher the mechanism of stress-responsive upregulation of downstream genes, simultaneously forming a molecular bridge between primary and specialized metabolisms. Though many studies have been conducted on the transcriptional regulation of stress-mediated primary or specialized metabolism genes, but not much data is available with regard to cis-element signatures and transcription factors that simultaneously modulate both pathway genes. Hence, our major focus would be to present a comprehensive analysis of the stress-mediated interconnection between primary and specialized metabolism genes via the interaction between different transcription factors and their corresponding cis-elements. In future, this study could be further utilized for the overexpression of the specific transcription factors that upregulate both primary and specialized metabolism, thereby simultaneously improving the yield and therapeutic content of plants

Oscillating Superfluidity of Bosons in Optical Lattices

We follow up on a recent suggestion by C. Orzel et. al., Science, 291, 2386 (2001), whereby bosons in an optical lattice would be subjected to a sudden parameter change from the Mott to the superfluid phase. We analyze the Bose Hubbard model with a modified coherent states path integral which can escribe - both - phases. The saddle point theory yields collective oscillations of the uniform superfluid order parameter. These would be seen in time resolved interference patterns made by the released gas. We calculate the collective oscillation's damping rate by phason pair emission. In two dimensions the overdamped region largely overlaps with the quantum critical region. Measurements of critical dynamics on the Mott side are proposed.Comment: 4 pages 1 eps figures; Final version as appears in PRL. Added discussion on spontaneous generation of vortice

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and deubiquitinases (DUBs) controls several aspects of β-cell functions. In this study, screening for key DUBs identified USP1 to be specifically involved in dedifferentiation process. Inhibition of USP1 either by genetic intervention or small-molecule inhibitor ML323 restored epithelial phenotype of β-cells, but not with inhibition of other DUBs. In absence of dedifferentiation cues, overexpression of USP1 was sufficient to induce dedifferentiation in β-cells; mechanistic insight showed USP1 to mediate its effect via modulating the expression of inhibitor of differentiation (ID) 2. In an in vivo streptozotocin (STZ)-induced dedifferentiation mouse model system, administering ML323 alleviated hyperglycemic state. Overall, this study identifies USP1 to be involved in dedifferentiation of β-cells and its inhibition may have a therapeutic application of reducing β-cell loss during diabetes

Density wave and supersolid phases of correlated bosons in an optical lattice

Motivated by the recent experiment on the Bose-Einstein condensation of $^{52}$Cr atoms with long-range dipolar interactions (Werner J. et al., Phys. Rev. Lett., 94 (2005) 183201), we consider a system of bosons with repulsive nearest and next-nearest neighbor interactions in an optical lattice. The ground state phase diagram, calculated using the Gutzwiller ansatz, shows, apart from the superfluid (SF) and the Mott insulator (MI), two modulated phases, \textit{i.e.}, the charge density wave (CDW) and the supersolid (SS). Excitation spectra are also calculated which show a gap in the insulators, gapless, phonon mode in the superfluid and the supersolid, and a mode softening of superfluid excitations in the vicinity of the modulated phases. We discuss the possibility of observing these phases in cold dipolar atoms and propose experiments to detect them

Hanbury Brown-Twiss Interferometry for Fractional and Integer Mott Phases

Hanbury-Brown-Twiss interferometry (HBTI) is used to study integer and fractionally filled Mott Insulator (MI) phases in period-2 optical superlattices. In contrast to the quasimomentum distribution, this second order interferometry pattern exhibits high contrast fringes in the it insulating phases. Our detailed study of HBTI suggests that this interference pattern signals the various superfluid-insulator transitions and therefore can be used as a practical method to determine the phase diagram of the system. We find that in the presence of a confining potential the insulating phases become robust as they exist for a finite range of atom numbers. Furthermore, we show that in the trapped case the HBTI interferogram signals the formation of the MI domains and probes the shell structure of the system.Comment: 13 pages, 15 figure

Phase diagram of the Bose-Hubbard Model on Complex Networks

Critical phenomena can show unusual phase diagrams when defined in complex network topologies. The case of classical phase transitions such as the classical Ising model and the percolation transition has been studied extensively in the last decade. Here we show that the phase diagram of the Bose-Hubbard model, an exclusively quantum mechanical phase transition, also changes significantly when defined on random scale-free networks. We present a mean-field calculation of the model in annealed networks and we show that when the second moment of the average degree diverges the Mott-insulator phase disappears in the thermodynamic limit. Moreover we study the model on quenched networks and we show that the Mott-insulator phase disappears in the thermodynamic limit as long as the maximal eigenvalue of the adjacency matrix diverges. Finally we study the phase diagram of the model on Apollonian scale-free networks that can be embedded in 2 dimensions showing the extension of the results also to this case.Comment: (6 pages, 4 figures

Atomic Bose-Fermi mixtures in an optical lattice

A mixture of ultracold bosons and fermions placed in an optical lattice constitutes a novel kind of quantum gas, and leads to phenomena, which so far have been discussed neither in atomic physics, nor in condensed matter physics. We discuss the phase diagram at low temperatures, and in the limit of strong atom-atom interactions, and predict the existence of quantum phases that involve pairing of fermions with one or more bosons, or, respectively, bosonic holes. The resulting composite fermions may form, depending on the system parameters, a normal Fermi liquid, a density wave, a superfluid liquid, or an insulator with fermionic domains. We discuss the feasibility for observing such phases in current experiments.Comment: 4 pages, 1 eps figure, misprints correcte

Reentrant Phenomenon in Quantum Phase Diagram of Optical Boson Lattice

We calculate the location of the quantum phase transitions of a bose gas trapped in an optical lattice as a function of effective scattering length a_{\eff} and temperature $T$. Knowledge of recent high-loop results on the shift of the critical temperature at weak couplings is used to locate a {\em nose} in the phase diagram above the free Bose-Einstein critical temperature $T_c^{(0)}$, thus predicting the existence of a reentrant transition {\em above} $T_c^{(0)}$, where a condensate should form when {\em increasing} a_{\eff}. At zero temperature, the transition to the normal phase produces the experimentally observed Mott insulator.Comment: Author Information under http://www.physik.fu-berlin.de/~kleinert/institution.htm

Glassy features of a Bose Glass

We study a two-dimensional Bose-Hubbard model at a zero temperature with random local potentials in the presence of either uniform or binary disorder. Many low-energy metastable configurations are found with virtually the same energy as the ground state. These are characterized by the same blotchy pattern of the, in principle, complex nonzero local order parameter as the ground state. Yet, unlike the ground state, each island exhibits an overall random independent phase. The different phases in different coherent islands could provide a further explanation for the lack of coherence observed in experiments on Bose glasses.Comment: 14 pages, 4 figures