Dichromacy: Color Vision Impairment and Consanguinity in Heterogenous Population of Pakistan

Background and Objectives: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in females, and in Iran, it is 8.18% in males and 0.43% in females. Population based epidemiological data about dichromacy in different ethnic groups in Pakistan is not available. The aim of this study was to find out the population prevalence of inherited red-green dichromacy in a heterogenous population of the district of Chiniot, Punjab, Pakistan, and to determine the impact of consanguinity and ethnicity. Methods: In this cross-sectional study, boys and girls of the higher secondary schools were examined in the three tehsils of district Chiniot. Pseudoisochromatic Ishihara Test has been employed for detection of dichromacy in the study population. The sample size was calculated statistically as 260, which was expanded to 705 and divided by population density of the three tehsils. Results: Screening of 359 males and 346 females revealed 19 (5.29%) dichromat males and only 2 (0.58%) females. The study population belonged to 23 castes / isonym groups. The consanguinity found in the district of Chiniot is 84.82% and in the dichromat families, it is 85.71%, of which 52.37% are first cousin. Interpretation & Conclusion: The study has shown that the incidence of dichromacy could be reduced through genetic counselin

Risk Factors of Diarrhoea in Malnourished Children Under Age of 5 Years

Background: Acute infectious enteritis remains one of the commonest causes of death among infants and children in developing countries. Acute enteritis is defined as a loss of stool consistency with pasty or liquid stools, and/or an increase in stool frequency to more than three stools in 24 hours with or without fever or vomiting. Human survival depends on the secretion and reabsorption of fluid and electrolytes in the intestinal tract. The objective of the study is to evaluate the risk factors of diarrhoea in children under age of 5 years. Methodology: It was an observational study. Study was completed in about six months. Non-probability purposive sampling technique was used. In this study, 270 samples were taken from Diarrheal ward of The Children Hospital Lahore, Pakistan. Results: In this study, out of 270 patients, 58.52% were males and 41.48% were females. 90.37% patients were vaccinated. 54.81% had weaning history. 91.85% patients had feeding history. 29.26% had blood in stool. 96.67% patients were dehydrated. 95.56% patients had loose watery diarrhoea. 62.96% patients used boiled water. 58.52% patients consumed less than half litre of water, 30.00% patients consumed 1 litre of water and 11.48% patients consumed > 1 litre of water. 49.18% patients had proper hygiene. 38.15% mothers of patients were well educated. 40.37% patients had model household condition. 57.41% patients lived in rural area and 42.59% patients lived in urban area. Conclusion: The variation in the level of diarrheal morbidity was well explained by maternal education, income, personal hygiene, refuse disposal system and the effect of health extension programme

Bacterial ventriculoperitoneal shunt infections: changing trends in antimicrobial susceptibility, a 7-year retrospective study from Pakistan

BACKGROUND: Ventriculoperitoneal (VP) shunt infections in adults represent a severe complication and make treatment more challenging. Therefore, drug susceptibility patterns are crucial for therapeutic decisions and infection control in neurosurgical centers. This 7-year retrospective study aimed to identify the bacteria responsible for adult VP shunt infections and determine their drug susceptibility patterns. METHODS: This single-center study was performed from 2015 to 2021 in Lahore, Pakistan, and included CSF cultures from VP shunt infections. Demographic data, causative organisms, and antimicrobial susceptibility testing results were collected. Multivariate analysis of variance (MANOVA) and two-sample t-tests were used to analyze and compare the antibiotic sensitivity trends over the study period. RESULTS: 14,473 isolates recovered from 13,937 CSF samples of VP shunt infections were identified and analyzed for their susceptibility patterns to antimicrobials. The proportion of Gram-negative and Gram-positive bacteria were 11,030 (76%) and 3443 (24)%, respectively. The predominant bacteria were Acinetobacter species (n = 5898, 41%), followed by Pseudomonas species (n = 2368, 16%) and coagulase-negative Staphylococcus (CoNS) (n = 1880, 13%). 100% of Staphylococcus aureus (S.aureus) and CoNS were sensitive to vancomycin and linezolid (n = 2580). However, 52% of S. aureus (719/1,343) were methicillin-resistant Staphylococcus aureus (MRSA). Acinetobacter showed maximum sensitivity to meropenem at 69% (2759/4768). Pseudomonas was 80% (1385/1863 sensitive to piperacillin-tazobactam, Escherichia coli (E. coli) showed 72% to amikacin (748/1055), while Klebsiella spp. was 57% (574/1170) sensitive to piperacillin-tazobactam. The sensitivity of piperacillin-tazobactam and meropenem for Gram-negative bacteria decreased significantly (p < 0.05) over 7 years, with 92.2% and 88.91% sensitive in 2015 and 66.7% and 62.8% sensitive in 2021, respectively. CONCLUSION: The significant decrease in the effectiveness of carbapenem and beta-lactam/beta-lactamase inhibitor combination drugs for the common Gram-negative causative agents of VP shunt infections suggests that alternative antibiotics such as colistin, fosfomycin, ceftazidime/avibactam, ceftolozane/tazobactam, and tigecycline should be considered and in consequence included in testing panels. Additionally, it is recommended to adopt care bundles for the prevention of VP shunt infection

Frequency of Predisposing Factor of Nausea and Vomiting After Chest Surgery Under General Anaesthesia

Background:&nbsp;Postoperative nausea and vomiting are common and distressing postsurgical symptoms. These symptoms are of particular concern in outpatient surgery because they may require additional direct resources, such as supplies and antiemetic drugs, and may delay discharge. The objective of this study was to measure the frequency of factors which can cause nausea and vomiting under general anaesthesia after chest surgery. Methodology:&nbsp;This descriptive case series evaluated frequency of predisposing factor of nausea and vomiting in patients of anaesthesia department of Gulab Devi Hospital Lahore. Questionnaire is made and patients were asked about their age, fever, previous surgery, NPO status, smoking history and hospital stay. This study included 140 patients with post-operative nausea and vomiting. Results:&nbsp;In this study, 140 patients were taken in which&nbsp; 65 (46.43%) were female and 75 (53.57%) were male. In 140 patient 134 (95.7%) were NPO and 6 (4.3%) were not &nbsp;NPO, 25 (17.9%) were obese and 115 (82.1%) were not obese, 88 (62.9%) patients were suffering fever and 52 (37.1%) were not suffering fever, 80 (57.1%) were infected and 59 (42.1%) were not infected, 53 (37.9%) patients had previous surgery and 87 (62.1%) had no previous surgery, 94 (67.1%) patients had received nitrous oxide and 46 (32.9%) didn\u27t, 97 (69.3%) received volatile gases and 43 (30.7%) not received, 29 (20.7%) received ketamine and 111 (79.3%) not received, 87 (62.1%) received suxamethonium and 53 (37.9%) not received, 119 (85.0%) received propofol and 21 (15.0%) not received, 110 (78.6%) received naluphine and 28 (20.0%) not received. Out of 140 patients, there were 122 (87.1%) who were suffering from pain and 18 (12.9%) were not. 91 (65.0%) patients had gastric distention and 49 (35.0%) patients didn\u27t. Opioids were given to 34 (24.3%) patients and not given to 106 (75.7%) patient. Conclusion:&nbsp;It is concluded that the nausea and vomiting after surgey under genral anesthesia is due to patient related factors in which most frequent is NPO. Drug related factors include propofol and nalbupin administration. Post operative factors include pain. In whole study of 140 patients, the&nbsp; most frequent is patient related factor (NPO) other than drug related factors and post-operative factors

Enhanced Arabic disaster data classification using domain adaptation

Natural disasters, like pandemics and earthquakes, are some of the main causes of distress and casualties. Governmental crisis management processes are crucial when dealing with these types of problems. Social media platforms are among the main sources of information regarding current events and public opinion. So, they have been used extensively to aid disaster detection and prevention efforts. Therefore, there is always a need for better automatic systems that can detect and classify disaster data of social media. In this work, we propose enhanced Arabic disaster data classification models. The suggested models utilize domain adaptation to provide state-of-the-art accuracy. We used a standard dataset of Arabic disaster data collected from Twitter for testing the proposed models. Experimental results show that the provided models significantly outperform the previous state-of-the-art results

Perencanaan Kolam Pelabuhan Pondok Dayung Fasharkan Tanjung Priok Jakarta Utara

Ports of Pondok Dayung is one of the special port designation refers to as one of the supporting facilities and infrastructure facilities NKRI defense, such as privatization TNI navy military has its have means to sea port don't depend on other agencies. Planning a pool port of Pondok Dayung Fasharkan design covering breakwaters, design port dock, grooves cruise design, as well as design lap pool port. Functionally, this port will be used as a berthing dock and military vessels, as well as a repair ships for the Navy in particular regional western Indonesia and the surrounding region. Planning begins with the data include wind speed data processing for generation forecasting waves in the sea area. The result shows the significant wave height (Ho = 1.53 m) and significant wave period (To = 9.585 sec) to reset wave when the plan for 50 years. Data processing tidal sea water as well as map data is used as reference planning bathimetry high elevation breakwater and dock buildings, from the calculation of the value obtained tidal sea level plan HHWL = + 51.4 cm, MSL = ± 0.0 cm, and LLWL = -34.6 cm. The data is used as reference fleet planning calculations obtained wide shipping channel groove width 216 m (two lines), and the great depth of the draft plan of the port pool D = ± 12.25 m from the sea bet. Geotek the data used to determine the characteristics of the soil used as reference planning building type breakwater, pier foundation and structure planning. Planning generated breakwater building type hypotenuse (1: 1.5) with a total length of 1292 m, the number of tier 2 Secondary layer 1 m thick layer of heavy stones to 168-200 kg layer Core layer in grain weight 16-20 kg, and design mercu elevation ± 3.79 m of MSL. Plan a total of 252 m long quay with a plan elevation of +1.07 m MSL, plan structure 20 cm thick floor slabs, pile foundation structure Spun Pile Ø 50 cm with concrete quality K 500. dock Fender ie type V (400H 1000L) the impact energy capacity of 160 kN, as well as the type fastening Bollard pull capacity of 35 tons

Wear mechanism of olivine at the small-scale: An in situ TEM study

The study of tribology includes wear, friction, and lubrication of interacting surfaces in relative motions. Since the function, efficiency, and lifetime of many engineering components depend on the appropriate friction and wear properties, the study of tribology has significant practical importance. However, traditional tribology tests are limited by the inability to observe real-time progress of the sliding contacts and wear mechanism. Recent developments in small-scale devices, particularly piezoelectric and MEMS-based actuators, aid in conducting scratches at the micro- and nano-scale in the TEM. Olivine is magnesium iron silicate (Mg²⁺, Fe²⁺)₂SiO₄ and the most abundant mineral in earth\u27s upper mantle, which comprises the bulk of the planet\u27s tectonic plates. Although the structure of olivine has been intensively studied by mineralogists and geophysicists, the frictional and mechanical properties particularly damage evolution at the small-scale of sliding contact is unknown. In this study, a bulk olivine sample was wedge polished and then fib-milled to prepare electron-transparent regions. A wedge diamond indenter of 100 nm radius and 3 um length was used to make sliding contact using a PI 95, TEM PicoIndenter. Multicycle scratch tests were conducted to understand wear behavior. During the wear passes, the kinetic friction coefficient remained relatively constant near 0.1 and substantial dislocation plasticity occurred in the sample. Each pass showed nucleation of additional dislocations which were arranged in a symmetric array along the wear path as shown in fig. 1. The talk will present a theory of friction and deformation behavior that are applicable to geological materials. Please click Additional Files below to see the full abstract

Perencanaan Kolam Pelabuhan Pondok Dayung Fasarkan Tanjung Priok Jakarta Utara

Ports of Pondok Dayung is one of the special port designation refers to as one of the supporting facilities and infrastructure facilities NKRI defense, such as privatization TNI navy military has its have means to sea port don't depend on other agencies. Planning a pool port of Pondok Dayung Fasarkan design covering breakwaters, design port dock, grooves cruise design, as well as design lap pool port. Functionally, this port will be used as a berthing dock and military vessels, as well as a repair ships for the Navy in particular regional western Indonesia and the surrounding region. Data processing in the planning include wind speed data processing used for forecasting wave generation in the area of the deep, significant wave height values obtained (Ho = 1.53 m) and significant wave period (To = 9.585 sec) using wave probabilias according Gumbel distribution (Fisher method type 1) when repeated waves during the 50-year plan. Data processing tidal water of the sea as well as the face of map data bathimetry high elevation used as reference breakwater planning and building a dock, from the calculation of the value obtained tidal water of sea level plan HHWL = + 51.4 cm, MSL = ± 0.0 cm, and LLWL = -34.6 cm. A fleet of data used as reference calculation wide planning a groove cruise obtained wide a groove 216 m (two paths) , and large the depth of the draft of the port plan the pool D=± 12.25 m from the sea bet. Data geotek worn to find out the characteristics of the ground used as reference planning breakwater type of the building , and planning foundation structure a wharf. Planning breakwater building used type of sloping side (1: 1.5) planned a total length L = 1292 m, the number of layers n = 2 Secondary layers thick layer t = 1 m heavy pieces of stone W = 168-200 kg for layers in the core layer of heavy point W = 16-20 kg, and the design elevation mercu of breakwater ± 3.79 m from MSL. Plan a wharf a total length of 252 m with elevation plan + 1,07 m of msl, plan a structure of plates thick the floor 20 cm, foundation structure piles spun pile Ø 50 cm with concrete quality K 500. Dock facilities that Fender type V (400H 1000L) with a impact energy capacity of 160 kN, as well as the type fastening a Bollard with pull capacity of 35 tons. During the planning there are several aspects of which suggested to examined more detail particularly on the big problem the value of sedimentation tranport large and shallow , with such a large value of sediment transport and sedimentation occurred in the port basin can be calculated and minimized optimally

Seeing new opportunities to help smokers quit: A UK national survey of optometrist delivered smoking cessation behavioural support interventions

Background: Smoking is a risk factor for various eye conditions. Brief smoking cessation interventions have demonstrated effectiveness when delivered by a range of healthcare professionals. Optometrists are well-placed in the community to advise otherwise healthy smokers to quit, yet remain relatively neglected in smoking cessation research and policy. In a national survey, this study investigated self-reported practices of UK optometrists for delivering brief tobacco smoking cessation interventions to patients. Methods: A randomly selected sample of 1,200 optometrists out of the 9000 optometrists registered on the UK College of Optometrists database were invited to complete a 40-item, web-based survey assessing: training related to smoking cessation; current practice [i.e. the proportion of patients to which components of very brief advice (Ask, Advise, Assist) and other evidence-based smoking cessation behaviour change techniques were delivered]; and barriers/enablers to intervention delivery. Results: In total, 408 (34%) responses were received. Most (83%) optometrists received no training in practical skills for delivering smoking cessation support. A third (34%) routinely assessed smoking status. Fewer self-reported advising smokers to quit (22%), offering assistance (via referral to dedicated services) (3%), or advice on smoking cessation medications (2%). Perceived barriers included insufficient knowledge/training (81%) and time (65%). Optometrists were more likely to assess and advise on smoking cessation if they practised in Scotland (χ²(2)=32.95,  p<0.001), an independent optometry practice (χ²(1)=4.27,  p=0.39), or had received smoking cessation training χ²(1)=13.1,  p<0.001). Conclusions: Substantial gaps exist in UK optometrists' current smoking cessation training and practice. Evidence-based training resources are needed to support the implementation of smoking cessation interventions into routine optometry practice. Implications: Optometrists are well placed in the community to delivery brief advice interventions to a large population of smokers. This survey provides a comprehensive description of current UK optometry practice related to the provision of evidence-based brief tobacco smoking cessation interventions to patients. Although optometrists perceive advising on smoking cessation as part of their role, numerous substantial gaps in current practice and training remain which need to be addressed through targeted interventions to increase implementation