ASSESSMENT OF BUSINESS ACTIVITY OF LLC «ELAN-95»

Assessment of business activity of LLC «Elan-95» for 2007-2015 is carried out. Efficiency of usage of current assets of the organization is analyzed. The analysis of indicators of business and market activity of LLC «Elan-95» is carried out. By results of the analysis conclusions and practical recommendations about improvement of efficiency of usage of means of the organization are carried out

ASSESSMENT OF BUSINESS ACTIVITY OF LLC «ELAN-95»

Assessment of business activity of LLC «Elan-95» for 2007-2015 is carried out. Efficiency of usage of current assets of the organization is analyzed. The analysis of indicators of business and market activity of LLC «Elan-95» is carried out. By results of the analysis conclusions and practical recommendations about improvement of efficiency of usage of means of the organization are carried out

Comparison of risk assessment models of BRCA1 and BRCA2 mutation carrier in patients with breast cancer.

Analysis of efficiency of the algorithm BOADICEA using and Manchester scoring system to predict the carrier of BRCA1 and BRCA2 mutations in Ukranian patients with breast cancer was performed. Materials for this study were the results of clinical, imunogistological, pathogistological, genealogical, molecular genetic researches of 146 patients with breast cancer. Calculations of mutations risk were performed using BOADICEA algorithm and Manchester scoring system. In the total group of patients the area under the curve while predicting BRCA1 mutations with algorithm BOADICEA was 0.86, with Manchester scoring system - 0.84, and in calculation of the combined risk of BRCA mutations - 0.83 and 0.84, respectively. However, statistical difference between the areas of algorithms has not been established (p> 0.05), it indicates to the same discriminatory power of the test models. Better sensitivity, specificity, positive and negative predictive value of results of BOADICEA algorithm was reached in 6% of BRCA1 probability and in 8% threshold of BRCA1/2 mutations. The Manchester scoring system has showed the best operating characteristics with 6 and 13-point probability of BRCA1 and BRCA1/2 mutations respectively. Patients with probability of mutations with such thresholds may be offered molecular study of pathogenic alleles

A STUDY OF SOCIAL ADVERTS WITH RESPECT TO THE IMAGE OF MUSLIM REFUGEES IN SOCIETY

Purpose: The article deals with the problem of changes in social values made by the influence of refugee culture and mind on the British society, which is widely known to be very stable and unchangeable via comparative qualitative research methods. Methodology: The qualitative research adopted an analytical-comparative method. Data were collected through observation, interviews and questionnaires. Main Findings: As a result, the value-ignored actions from the Love letter are the most diverse in value types and in the number of uses in the text. In conclusion, when considering the verb value-oriented expressions, it is noted that there are much more positive actions than negative ones. Applications: This article can be used by regional schools, cultural organizations and universities. Novelty/Originality: The crisis of ideology in the field of morality in the modern social situation related to the problems of immigrants has been studied

CP and related phenomena in the context of Stellar Evolution

We review the interaction in intermediate and high mass stars between their evolution and magnetic and chemical properties. We describe the theory of Ap-star `fossil' fields, before touching on the expected secular diffusive processes which give rise to evolution of the field. We then present recent results from a spectropolarimetric survey of Herbig Ae/Be stars, showing that magnetic fields of the kind seen on the main-sequence already exist during the pre-main sequence phase, in agreement with fossil field theory, and that the origin of the slow rotation of Ap/Bp stars also lies early in the pre-main sequence evolution; we also present results confirming a lack of stars with fields below a few hundred gauss. We then seek which macroscopic motions compete with atomic diffusion in determining the surface abundances of AmFm stars. While turbulent transport and mass loss, in competition with atomic diffusion, are both able to explain observed surface abundances, the interior abundance distribution is different enough to potentially lead to a test using asterosismology. Finally we review progress on the turbulence-driving and mixing processes in stellar radiative zones.Comment: Proceedings of IAU GA in Rio, JD4 on Ap stars; 10 pages, 7 figure

Statistics of Magnetic Fields for OB Stars

Based on an analysis of the catalog of magnetic fields, we have investigated the statistical properties of the mean magnetic fields for OB stars. We show that the mean effective magnetic field ${\cal B}$ of a star can be used as a statistically significant characteristic of its magnetic field. No correlation has been found between the mean magnetic field strength ${\cal B}$ and projected rotational velocity of OB stars, which is consistent with the hypothesis about a fossil origin of the magnetic field. We have constructed the magnetic field distribution function for B stars, $F({\cal B})$, that has a power-law dependence on ${\cal B}$ with an exponent of $\approx -1.82$. We have found a sharp decrease in the function $F({\cal B})$F for {\cal B}\lem 400 G that may be related to rapid dissipation of weak stellar surface magnetic fields.Comment: 22 pages, 7 figures, accepted Astronomy Letters, 2010, vol.36, No.5, pp.370-379, contact E-mail: [email protected]

FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY

To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods. The study included 86 patients with CAD, including 35 with moderate atherosclerotic lesions of the coronary arteries (CA) (SYNTAX Score ≤22), 22 with severe (SYNTAX Score of 23-31 pints), 29 with extremely severe (SYNTAX Score ≥32). As a comparison group, 52 patients with heart defects were examined. During an elective surgical intervention, adipose tissue (AT) samples were obtained for subsequent cultivation and determination of PAI-1 gene expression and PAI-1 secretion in AT supernatants of various localizations. Statistical analysis was performed using Statistica 10.0.Results. In CAD, PAI-1 production in all three types of AT and plasma PAI-1 concentration were increased compared with patients with heart defects. Epicardial AT (EAT) in CAD was characterized by the maximum levels of expression and secretion of PAI-1 relative to patients with heart defects and subcutaneous and perivascular (PVAT) fat depots. Moderate coronary involvement (adipose tissue <22) is characterized by the lowest expression and secretion of PAI-1 in all types of AT and plasma concentration of PAI-1. Direct correlations of PAI-1 expression and secretion in EAT and PVAT and plasma PAI-1 level with its secretion in EAT in patients with CAD and heart defects were revealed. A direct correlation between the plasma level of PAI-1 and its secretion in PVAT was found only in CAD.Conclusion. In CAD, there is not only an increase in the plasma PAI-1 level, but also an increase in the expression of PAI-1 gene and the secretion of PAI-1 in all three types of AT compared with patients with heart defects. PAI-1 expression and secretion in EAT, PAI-1 plasma level, and age are predictors of severe/extremely severe coronary involvement in CAD

ИФЛА и ЦУР: обзор проектов Секции окружающей среды, устойчивого развития и библиотек

Among the other IFLA sections and thematic groups, IFLA Environment, Sustainability and Libraries Section (ENSULIB) is in the thick of sustainability problems and, in particular, of ecological component of the Sustainable Development Goals (SDG). ENSULIB encourages the libraries to inspire their communities for the ecologically sustainable course of action through providing materials on “green” librarianship, giving the floor to “green” librarians and library projects, by taking the lead and propounding the discussion.On IFLA ENSULIB web page, one can find materials and projects for the libraries working in ecological education and advocating sustainability ideas, and among these initiatives are IFLA Green Library Award, news bulletin, open access thematic information resource, Library Map of the World Project, and regular webinars. The ENSULIB provides support to zero-waste and decrease-ofconsumption projects. The authors discuss the materials that might be useful for Russian libraries.Среди множества секций и тематических групп Международной федерации библиотечных ассоциаций (ИФЛА) наиболее плотно вопросами устойчивого развития, а особенно вопросами, связанными с экологической составляющей Целей устойчивого развития (ЦУР), занимается Секция окружающей среды, устойчивого развития и библиотек (Environment, Sustainability and Libraries Section – ENSULIB). Деятельность ENSULIB направлена на то, чтобы библиотекари вдохновляли свои сообщества на более экологически устойчивый образ действий, предоставляя материалы по «зелёному библиотечному делу», давая слово «зелёным библиотекарям и библиотечным проектам», подавая пример и предлагая обсуждение этих вопросов.На тематической странице секции на сайте ИФЛА представлено множество материалов и проектов для библиотек, работающих в области экологического просвещения и продвижения идей устойчивого развития. Среди них: премия ИФЛА «Зелёная библиотека», информационный бюллетень, общедоступный тематический информационный ресурс, проект «Библиотечная карта», регулярные вебинары. Оказана поддержка проектам, призванным сократить выбросы и снизить уровень потребления. В статье освещены материалы, которые могут быть использованы в деятельности российских библиотек

Optimization of blood pressure control, organ protection and metabolic disorders using a fixed-dose combination of lisinopril+amlodipine+rosuvastatin in hypertensive patients after COVID-19

Aim. To evaluate the potential of a fixed-dose combination of lisinopril+amlodipine+rosuvastatin (Equamer®) in achieving additional vascular protection in patients with hypertension and high pulse wave velocity (PWV) after severe and very severe coronavirus disease 2019 (COVID-19), complicated by bilateral multisegmental viral pneumonia, with the use of biological therapy, who had not previously received combination antihypertensive therapy.Material and methods. This 12-week open-label observational study included 30 patients with or without antihypertensive therapy. The patients underwent 24-hour blood pressure monitoring, applanation tonometry (determination of the augmentation index (AI) and central blood pressure (CBP)), PWV measurement, blood laboratory tests (lipid profile, fasting glucose, C-reactive protein, complete blood count, ferritin, fibrinogen, D-dimer, alanine aminotransferase, aspartate aminotransferase, creatinine, uric acid) before and after switch to a fixed-dose combination of lisinopril+amlodipine+rosuvastatin.Results. At baseline, the patients had an increase in office blood pressure (BP) up to 152,6/89,1 mm Hg. After prescribing a fixed-dose combination of lisinopril+amlodipine+rosuvastatin, there was a decrease in systolic blood pressure (SBP) by 15,8% and diastolic blood pressure (DBP) by 12,2%. According to 24-hour blood pressure monitoring, the decrease in SBP was 15%, DBP — by 9%, PWV — by 23,8%, AI — by 9%, CBP — by 12,4% (p<0,05 for all compared to baseline values). Vascular age (VA) was initially increased to 41,9 years with a chronological age of 35,03 years. After the end of therapy, there was a significant decrease in VA to 36,5 years, low-density lipoproteins by 46,8%, triglycerides by 16,8% and an increase in high-density lipoproteins by 10,7% (p<0,05 for all compared to baseline values). In addition, the levels of C-reactive protein, fibrinogen, D-dimer, glucose, and uric acid significantly decreased.Conclusion. The fixed-dosed combination of lisinopril+amlodipine+rosuvastatin provides better blood pressure control, improved vascular elasticity parameters (AI, PWV, CBP, decrease in VA), and also improves lipid and carbohydrate metabolism, reduces inflammation in patients with hypertension and hyperlipidemia after severe COVID-19