TD-88Up - Upgraded Neutral Earth's Thermosphere Total Density TD-88 Model

Improved constants of the total density TD-88 model for the Earth'sneutral thermosphere are calculated. The model is fully functional within theheight range of 200 to 500 km, with fixed values of the mean solar flux andgeomagnetic index. The control data of the atmospheric air density are derivedfrom the aeronomical NRLMSISE-00 model which was used as the reference one.The upgraded TD-88, named TD-88Up, model is obtained by the extended LSQ methodwith varying all model parameters

Supplementary data for article: Šegan, S.; Božinović, N.; Opsenica, I.; Andrić, F. Consensus-Based Comparison of Chromatographic and Computationally Estimated Lipophilicity of Benzothiepino[3,2-c]Pyridine Derivatives as Potential Antifungal Drugs. Journal of Separation Science 2017, 40 (10), 2089–2096. https://doi.org/10.1002/jssc.201601442

Supporting information for: [https://doi.org/10.1002/jssc.201601442]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2462]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3076

Supplementary data for article: Šegan, S.; Božinović, N.; Opsenica, I.; Andrić, F. Consensus-Based Comparison of Chromatographic and Computationally Estimated Lipophilicity of Benzothiepino[3,2-c]Pyridine Derivatives as Potential Antifungal Drugs. Journal of Separation Science 2017, 40 (10), 2089–2096. https://doi.org/10.1002/jssc.201601442

Supporting information for: [https://doi.org/10.1002/jssc.201601442]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2462]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3076

Supplementary material for the article: Božinović, N.; Šegan, S.; Vojnovic, S.; Pavic, A.; Šolaja, B. A.; Nikodinovic-Runic, J.; Opsenica, I. M. Synthesis and Anti-Candida Activity of Novel Benzothiepino[3,2-c]Pyridine Derivatives. Chemical Biology and Drug Design 2016, 88 (6), 795–806. https://doi.org/10.1111/cbdd.12809

Supplementary material for: [https://doi.org/10.1111/cbdd.12809]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2346]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3620

The Sigma - D relation for planetary nebulae

We present an extended analysis of the relation between radio surface brightness and diameter -- the so-called $\Sigma-D$ relation for planetary nebulae (PNe). We revise our previous derivation of the theoretical $\Sigma-D$ relation for the evolution of bremsstrahlung surface brightness in order to include the influence of the fast wind from the central star. Different theoretical forms are derived: $\Sigma \propto D^{-1}$ for the first and second phases of evolution and $\Sigma\propto D^{-3}$ for the final stage of evolution. Also, we analyzed several different Galactic PN samples. All samples are influenced by severe selection effects, but Malmquist bias seems to be less influential here than in the supernova remnant (SNR) samples. We derived empirical $\Sigma-D$ relations for 27 sample sets using 6 updated PN papers from which an additional 21 new sets were extracted. Twenty four of these have a trivial form of $\beta \approx 2$. However, we obtain one empirical $\Sigma-D$ relation that may be useful for determining distances to PNe. This relation is obtained by extracting a recent nearby (< 1 kpc) Galactic PN sample.Comment: 12 pages, 3 tables, 4 figures. Accepted for publication in Astronomy & Astrophysic

Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria

Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC50 values for such derivatives ranged from 0.81 to 2.27 mu M). Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors with nanomolar-range potencies (e.g., the K-i of compound 67 is 0.10 mu M). During BoNT/A challenge using primary neurons, select derivatives protected SNAP-25 by up to 89%. Docking simulations were performed to rationalize the compounds' in vitro potencies. In addition to specific residue contacts, coordination of the enzyme's catalytic zinc and expulsion of the enzyme's catalytic water were a consistent theme. With respect to antimalarial activity, the compounds provided better IC90 activities against chloroquine resistant (CQR) malaria than CQ, and seven compounds were more active than mefloquine against CQR strain W2

Digitization of the Belgrade Astronomical Observatory's vertical circle observational heritage

The aim of the paper is to present the digitization of the results of last observations of bright stars made by the Belgrade vertical circle ASKANIA N±80118 (D = 190 mm, f = 2578 mm) at the Astronomical Observatory of Belgrade. The observations are mainly made by Djuro Bozhichkovich in the period between 1982 and 1985. All of the found observational data and intermediary results are referenced and presented and some research possibilities are suggested. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III044006

PR and PL (PMv) relations for classical Cepheids revisited

Using observational data available for a large number of Galactic Cepheids, we determine the relation between the radius and the period of pulsations, by means of a variant of the Baade-Wesselink method. Using, further, the brightness parameter according to the Barnes-Evans approach, we achieve our final goal, determination of the relation between the period and the mean luminosity. The coefficients in both relations are realistic. We indicate the need for accurate angular diameters of the Cepheids, which would be useful since the Cepheids are standard candles in the cosmic distance scale

TD-88Up: Upgraded neutral Earth's thermosphere total density TD-88 model

Improved constants of the total density TD-88 model for the Earth's neutral thermosphere are calculated. The model is fully functional within the height range of 200 to 500 km, with fixed values of the mean solar flux and geomagnetic index. The control data of the atmospheric air density are derived from the aeronomical NRLMSISE-00 model which was used as the reference one. The upgraded TD-88, named TD-88Up, model is obtained by the extended LSQ method with varying all model parameters

Some results regarding the comparison of the Earth's atmospheric models

In this paper we examine air densities derived from our realization of aeronomic atmosphere models based on accelerometer measurements from satellites in a low Earth's orbit (LEO). Using the adapted algorithms we derive comparison parameters. The first results concerning the adjustment of the aeronomic models to the total-density model are given