Association of maternal serum triglycerides at term and macrosomia in gestational diabetes mellitus

Background: Aim of the study was to determine association of maternal serum triglycerides (TG) at term and macrosomia in gestational diabetes mellitus (GDM). Methods: A cross sectional study was carried out in the department of obstetrics and gynaecology, RIMS, Manipur. The study was conducted for 2 years duration from September 2019 to August 2021 and 85 singleton term pregnant women with GDM were included. All the patients were subjected to check fasting serum TG, FBS, PPBS. Descriptive statistics like mean, standard deviation and Inferential statistics like Chi-square test was used for comparing study variables between large for gestational age (LGA) and non LGA group. T-test was used to compare the mean values of age, pre-pregnancy BMI, pregnancy weight gain, OGTT, FBS, PPBS, fasting serum TG between LGA and non LGA group. Results: The observed mean TG values in LGA and non LGA group in our study was 262.35±26.08 and 158.18±13.24 mg/dL respectively. The serum TG values in the LGA group mothers was significantly higher when compared to the non LGA group. The mean weight gain in pregnancy 15.17±1.82 and 9.60±1.47 in LGA and non LGA respectively. The mean BMI comparison among LGA and non LGA are 27.7±1.74 and 22.94±1.6 respectively. Conclusions: It is observed that maternal fasting serum TG may be a strong predictor of foetal size irrespective of the glycemic status. Our study clearly pointed out the usefulness of measuring serum TG in GDM pregnancy. In addition to maternal hypertriglyceridemia, pre-pregnancy BMI, excessive weight gain in pregnancy significantly associated with foetal macrosomia in GDM mothers

A cross sectional study of pregnancy outcome in women with recurrent pregnancy loss

Background: Recurrent pregnancy loss occurs in approximately 1-2% of reproductive aged women. Aetiology is unknown in approximately 50% of RPL. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Maternal age and number of previous miscarriages are two independent risk factors. The study was conducted to determine the pregnancy outcomes in women with history of recurrent pregnancy loss. Methods: A hospital based cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences, Imphal. The study was carried out during a period of 2 years with effect from September 2019 to August 2021. Results: A total of 116 pregnant women with history of recurrent pregnancy loss were included in the study. The mean age among participants was 30.28±5.48 years. The average number of abortions prior to this pregnancy was 2.53±1.02. About 85.34% had spontaneous onset of labour and nearly equal proportion of (48.27% and 46.56%) of the participants delivered by NVD and CS. Maternal complications were present in 51.72%. Most common were hypertensive disorder (12.06%) and preterm labour (12.06%). Fetal complications were observed in 22.4% of newborn, commonest being low birth weight. Conclusions: Women with history of recurrent pregnancy loss encountered increased adverse maternal complications however fetal complications were similar to that of the general population. The definition, diagnosis and treatment of patients with a history of RPL remains difficult. Increased antenatal surveillance to reduce the risk of pregnancy complications with better screening of the obstetrical history and the necessary investigations to identify a treatable cause associated with previous miscarriages can lead to early prophylactic interventions for a better outcome

Scientific Evaluation of Anti-Analgesic and Anti-Inflammatory Efficacy of a Siddha Drug, Sivathai Chooranam

Siddha medicine offers an unceasing development in medical practice for a number of metabolic diseases and lifestyle disorders. The present study was to evaluate the anti analgesic and anti-inflammatory potential of Sivathai chooranam. The animals were divided into 5 groups of 6 animals each {control, standard – Indomethacin (5mg/kg, i.p), sivathai chooranam 0.108mg/kg(po), Sivathai chooranam 0.44 mg/kg(po) and Sivathai chooranam 2.7mg/kg(po). The analgesic activity of the extracts was evaluated using acetic acid induced writhing method and in vitro anti-inflammatory activity was evaluated using HRBC membrane stabilization assay and egg albumin denaturation assay. In acetic acid induced writhing model of analgesia, the number of writhes (in 30 minutes) was highest in control group (49.5±1.707) and lowest in Indomethacin group (26.25±0.629). Analgesic activity in sivathai chooranam at 2.7mg/kg concentration has registered lowest number of writhes (26.25±0.629) compared other drug concentrations tested and it was statistically significant as compared to control group. The concentration of 250µg/ml of Sivathai chooranam has exhibited a maximum percentage of haemolysis (88.24±0.73%) and albumin (protein) denaturation (84.51±0.66%) while the same concentration of standard drug of hydrocortisone represented the haemolysis was 88.94 ± 1.27% and Diclofenac sodium showed the 89.18±0.76 % of protein denaturation. The results of the work indicate that the Siddha medicine, Sivathai chooranam has possessed remarkable anti analgesic and anti inflammatory potential and can be applied as alternative in the treatment of painful conditions and inflammatory complications

Assessment on the Pattern of Drug Information Queries in a Tertiary Care Hospital, Chennai

The drug information services help to assist healthcare workers to address patient-specific drug-related needs and promote rational drug use. The objective of the study is to assess the pattern of drug information queries in a tertiary care hospital from the Physician, Nurses, Pharmacists, Students, and other healthcare professionals. In one year, the drug information queries have been received, documented and retrospectively analyzed for various parameters including the professional status of the requestor, mode of receipt and reply, type and purpose of query, and reference details. Out of 588 queries received, the majority were answered by Physicians (n=468; 79.59%), followed by Pharmacists (n=55; 9.35%), Nurses (n=15; 2.55%), also Technicians (n=9; 1.53%), Students (n=21; 3.58%), Patients (n=3; 0.5%) and other health care professionals (n=17; 2.90%). The secondary resources (Micromedex/Medscape) were used majorly, followed by Textbooks (n=117; 19.89%), Internet (n=103; 17.51%), Journals (n=23; 3.9%) and others (n=5; 0.85%). The most common drug-related query was Pharmacological drug profile (n=149; 25.34%) and including Product identification (n=132; 22.44%), Product Information (n=84; 14.28%), Adverse Drug Reactions (n=74; 12.58%), Therapeutic uses (n=55; 9.35%) and others (n=94; 15.98%). Drug Information Services has been developed to promote rational prescribing patterns among prescribers, reduce medication errors and provide better clinical outcomes. Keywords: Drug Information Centre (DIC), Query, Drug Information Services, Patient care, Tertiary Care Hospital, Clinical Pharmacist

Abstracts of the International Conference on Recent Trends in Mathematics and Computer Science 2023

This book presents the abstracts of the selected contributions to the International Conference on Recent Trends in Mathematics and Computer Science 2023 (ICRTMCS-2023), held on 19-21 October 2023 by the Auxilium College of Arts and Science for Women, Regunathapuram, Tamil Nadu, India. ICRTMCS-2023 was a multidisciplinary conference organized with the objective of bringing together eminent academicians, research scholars, and students to exchange ideas, communicate, to discuss research findings and new advances on recent and emerging trends in the field of Mathematics and Computer Science. Moreover, the conference would also enable the participants to explore new fields and gain immense knowledge. Conference Title: International Conference on Recent Trends in Mathematics and Computer Science 2023Conference Acronym: ICRTMCS-2023Conference Date: 19-21 October 2023Conference Venue: Hybrid (Online and Auxilium College of Arts and Science for Women, Regunathapuram, India)Conference Organizer: Departments of Mathematics and Computer Science, Auxilium College of Arts and Science for Women, Regunathapuram, Tamil Nadu, Indi