20,377 research outputs found
Non-commutative p-adic L-functions for supersingular primes
Let E/Q be an elliptic curve with good supersingular reduction at p with
a_p(E)=0. We give a conjecture on the existence of analytic plus and minus
p-adic L-functions of E over the Zp-cyclotomic extension of a finite Galois
extension of Q where p is unramified. Under some technical conditions, we adopt
the method of Bouganis and Venjakob for p-ordinary CM elliptic curves to
construct such functions for a particular non-abelian extension.Comment: 13 pages; some minor corrections; to appear in International Journal
of Number Theor
Superconductivity at 5.2 K in ZrTe3 polycrystals and the effect of Cu, Ag intercalation
We report the occurrence of superconductivity in polycrystalline samples of
ZrTe3 at 5.2 K temperature at ambient pressure. The superconducting state
coexists with the charge density wave (CDW) phase, which sets in at 63K. The
intercalation of Cu or Ag, does not have any bearing on the superconducting
transition temperature but suppresses the CDW state. The feature of CDW anomaly
in these compounds is clearly seen in the DC magnetization data. Resistivity
data is analysed to estimate the relative loss of carriers and reduction in the
nested Fermi surface area upon CDW formation in the ZrTe3 and the intercalated
compounds.Comment: 5 pages, 8 figure
Investigation of radar backscattering from second-year sea ice
The scattering properties of second-year ice were studied in an experiment at Mould Bay in April 1983. Radar backscattering measurements were made at frequencies of 5.2, 9.6, 13.6, and 16.6 GHz for vertical polarization, horizontal polarization and cross polarizations, with incidence angles ranging from 15 to 70 deg. The results indicate that the second-year ice scattering characteristics were different from first-year ice and also different from multiyear ice. The fading properties of radar signals were studied and compared with experimental data. The influence of snow cover on sea ice can be evaluated by accounting for the increase in the number of independent samples from snow volume with respect to that for bare ice surface. A technique for calculating the snow depth was established by this principle and a reasonable agreement has been observed. It appears that this is a usable way to measure depth in snow or other snow-like media using radar
Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex
ABSTRACT
The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the immune response. Here, we investigate how functional stability of Env relates to neutralization sensitivity to V2 bnAbs and V3 crown antibodies that engage subunit interfaces upon binding to unliganded Env. Env heterogeneity was inferred when antibodies neutralized a mutant Env with a plateau of less than 100% neutralization. A statistically significant correlation was found between the stability of mutant Envs and the MPN of V2 bnAb, PG9, as well as an inverse correlation between stability of Env and neutralization by V3 crown antibody, 447-52D. A number of Env-stabilizing mutations and V2 bnAb-enhancing mutations were identified in Env, but they did not always overlap, indicating distinct requirements of functional stabilization versus antibody recognition. Blocking complex glycosylation of Env affected V2 bnAb recognition, as previously described, but also notably increased functional stability of Env. This study shows how instability and heterogeneity affect antibody sensitivity of HIV-1 Env, which is relevant to vaccine design involving its dynamic apex.
IMPORTANCE
The Env trimer is the only viral protein on the surface of HIV-1 and is the target of neutralizing antibodies that reduce viral infectivity. Quaternary epitopes at the apex of the spike are recognized by some of the most potent and broadly neutralizing antibodies to date. Being that their glycan-protein hybrid epitopes are at subunit interfaces, the resulting heterogeneity can lead to partial neutralization. Here, we screened for mutations in Env that allowed for complete neutralization by the bnAbs. We found that when mutations outside V2 increased V2 bnAb recognition, they often also increased Env stability-of-function and decreased binding by narrowly neutralizing antibodies to the V3 crown. Three mutations together increased neutralization by V2 bnAb and eliminated binding by V3 crown antibodies. These results may aid the design of immunogens that elicit antibodies to the trimer apex.
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Zero-temperature criticality in the two-dimensional gauge glass model
The zero-temperature critical state of the two-dimensional gauge glass model
is investigated. It is found that low-energy vortex configurations afford a
simple description in terms of gapless, weakly interacting vortex-antivortex
pair excitations. A linear dielectric screening calculation is presented in a
renormalization group setting that yields a power-law decay of spin-wave
stiffness with distance. These properties are in agreement with low-temperature
specific heat and spin-glass susceptibility data obtained in large-scale
multi-canonical Monte Carlo simulations.Comment: 4 pages, 4 figure
Global Solutions for Incompressible Viscoelastic Fluids
We prove the existence of both local and global smooth solutions to the
Cauchy problem in the whole space and the periodic problem in the n-dimensional
torus for the incompressible viscoelastic system of Oldroyd-B type in the case
of near equilibrium initial data. The results hold in both two and three
dimensional spaces. The results and methods presented in this paper are also
valid for a wide range of elastic complex fluids, such as magnetohydrodynamics,
liquid crystals and mixture problems.Comment: We prove the existence of global smooth solutions to the Cauchy
problem for the incompressible viscoelastic system of Oldroyd-B type in the
case of near equilibrium initial dat
Void-mediated formation of Sn quantum dots in a Si matrix
Atomic scale analysis of Sn quantum dots (QDs) formed during the molecular beam-epitaxy (MBE) growth of Sn_xSi_(1−x) (0.05 ⩽ x ⩽ 0.1) multilayers in a Si matrix revealed a void-mediated formation mechanism. Voids below the Si surface are induced by the lattice mismatch strain between Sn_xSi_(1−x) layers and Si, taking on their equilibrium tetrakaidecahedron shape. The diffusion of Sn atoms into these voids leads to an initial rapid coarsening of quantum dots during annealing. Since this formation process is not restricted to Sn, a method to grow QDs may be developed by controlling the formation of voids and the diffusion of materials into these voids during MBE growth
Solution-processed bilayer photovoltaic devices with nematic liquid crystals
The cross-linking of polymerisable liquid crystalline semiconductors is a promising approach to solution-processable, multilayer, organic photovoltaics. Here we demonstrate an organic bilayer photovoltaic with an insoluble electron-donating layer formed by cross-linking a nematic reactive mesogen. We investigate a range of perylene diimide (PDI) materials, some of which are liquid crystalline, as the overlying electron acceptor layer. We find that carrier mobility of the acceptor materials is enhanced by liquid crystallinity and that mobility limits the performance of photovoltaic devices. © 2013 © 2013 Taylor & Francis
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