Observational and genetic evidence support a relationship between cardiac autonomic function and blood pressure

BackgroundIt is unclear how cardiac autonomic function, as indicated by heart rate (HR), heart rate variability (HRV), HR increase during exercise, and HR recovery after exercise, is related to blood pressure (BP). We aimed to examine the observational and genetic evidence for a potential causal effect of these HR(V) traits on BP.MethodsWe performed multivariable adjusted linear regression using Lifelines and UK Biobank cohorts to investigate the relationship between HR(V) traits and BP. Linkage disequilibrium score regression was conducted to examine genetic correlations. We used two-sample Mendelian randomization (2SMR) to examine potential causal relations between HR(V) traits and BP.ResultsObservational analyses showed negative associations of all HR(V) traits with BP, except for HR, which was positively associated. Genetic correlations were directionally consistent with the observational associations, but most significant genetic correlations between HR(V) traits and BP were limited to diastolic blood pressure (DBP). 2SMR analyses suggested a potentially causal relationship between HR(V) traits and DBP but not systolic blood pressure (SBP). No reverse effect of BP on HR(V) traits was found. One standard deviation (SD) unit increase in HR was associated with a 1.82 mmHg elevation of DBP. In contrast, one ln(ms) unit increase of the root mean square of the successive differences (RMSSD) and corrected RMSSD (RMSSDc), decreased DBP by 1.79 and 1.83 mmHg, respectively. For HR increase and HR recovery at 50 s, every additional SD increase was associated with a lower DBP by 2.05 and 1.47 mmHg, respectively. Results of secondary analyses with pulse pressure as outcome were inconsistent between observational and 2SMR analyses, as well as between HR(V) traits, and therefore inconclusive.ConclusionBoth observational and genetic evidence show strong associations between indices of cardiac autonomic function and DBP, suggesting that a larger relative contribution of the sympathetic versus the parasympathetic nervous system to cardiac function may cause elevated DBP

Climate Change Impact on Monthly Precipitation Wet and Dry Spells in Arid Regions: Case Study over Wadi Al-Lith Basin

Durations of monthly precipitation wet and dry spells are calculated using historical records and regional climate model (RCM) simulations for the Wadi Al-Lith basin in western Saudi Arabia. The characteristics of durations of wet and dry spells are based on the 50% risk level corresponding to the monthly records for average regional precipitation. The duration of wet spells in the model data is compared with observations for the base period 1971–2000. The impact of climate change on the durations of wet and dry spells is obtained using three global climate models projections with RCP4.5 and RCP8.5 scenarios downscaled by RCM. The probability distribution functions (PDFs) of the climate model scenarios and the precipitation records for the base period prove that climate change has a clear impact on the durations of wet and dry spells over the study area. There is an increase in wet spells frequency in the far future (2070–2099) compared to the near future (2020–2049). The increase in wet spells can be partly explained by the increase in extreme rainfall events and by the decrease in dry spells expected to occur over the study area towards the end of 21st century

What is the role of bosentan in healing of femur fractures in a rat model?

ATMACA, HASAN TARIK/0000-0001-8379-4114; Yayla, Muhammed/0000-0002-0659-3084WOS: 000360706700004PubMed: 25298328The purpose of this study was to examine the effects bosentan (which is a strong vasoconstrictor) on bone fracture pathophysiology, and investigate the roles of the nonselective endothelin 1 receptor blocker bosentan on the bone fractures formed in rats through radiographic, histopathologic, and immunohistochemical methods. The rats were divided into three groups (six rats in each group): a femoral fracture control group, a femoral fracture plus bosentan at 50 mg/kg group, and a femoral fracture plus bosentan at 100 mg/kg group. The femoral fracture model was established by transversely cutting the femur at the midsection. After manual reduction, the fractured femur was fixed with intramedullary Kirschner wires. The radiographic healing scores of the bosentan 100 and 50 mg/kg groups were significantly better that those of the fracture control group. The fracture callus percent of new bone in the bosentan 100 mg/kg group was significantly greater than that in the control group. Also, semiquantitative analysis showed higher positive vascular endothelial growth factor and osteocalcin staining and lower positive endothelin receptor type A staining in the treatment groups than in the control group. Bosentan treatment also decreased tissue endothelin 1 expression relative to that in the fracture control group. As a result of our study, the protective effect of bosentan was shown in experimental femoral fracture healing in rats by radiographic, histopathologic, and molecular analyses.Ataturk University Medical Research CouncilAtaturk University [2012/03]We thank Marc Iglarz and Actelion Pharmaceuticals Ltd for providing us with bosentan. This work was supported by the Ataturk University Medical Research Council (grant number 2012/03)

Success of Minimally Invasive Single-Gland Exploration Using the Quick Intra-Operative Parathyroid Assay

Objective : Using accurate localization techniques and the quick intra-operative parathyroid assay (QPTH), surgery for primary hyperparathyroidism due to a solitary adenoma has moved from the traditional wide bilateral neck exploration to more limited approaches such as minimally invasive single-gland exploration (MISGE) and minimally invasive radio-guided parathyroidectomy (MIRP). This study investigated whether the MISGE could take the place of MIRP with the help of the QPTH