Manganese-doped Mesoporous Silica Nanopowder for Pharmaceutical Applications

The purpose of the research was to produce and analyze properties of manganesedoped mesoporous silica nanopowder (NP) for biomedical applications. SiO2-MnO2 NP were produced by pulsed electron evaporation demonstrated high porosity amorphous structure, magnetic properties increased with addition of dopant. The toxicity experiments on cells showed that SiO2-MnO2 NP exerted low toxicity. Loading experiments showed qualitative interaction of antibiotic “Amoxicillin” with NP surface. According to obtained properties, produced SiO2-MnO2mesoporous NP is potential material for creating targeted drug delivering system. Keywords: mesoporous silica nanopowder, doped with manganese dioxide, targeted drug delivery

An investigation of the disinfection effect in joint action of the nanosecond electron beam and plasma radiation

The subject of the investigation of the possible synergy sterilizing effect included the joint action by the nanosecond electron beam (NEB) and plasma radiation of nanosecond gas discharge of high pressure. Plasma radiation was carried out by the GVI-150 generator which loading involved a discharge camera. Pulse repetition rate of the generator operation was 37 pps, and distance from electrodes cutoff to processed samples ∼5 cm. The experiments on irradiation by the NEB were made on the pulse repetitive nanosecond accelerator URT-0.5 (electrons energy up to 500 keV, a pulse duration 50 ns, pulse repetition rate up to 200 pps). The time the vessel has been irradiated changed from 0 to 5 minutes; the absorbed dose (AD) of different batches changed from 0 to 5 kGy. The extensive data array on joint action of the NEB and plasma radiation for several types of widespread microorganism is received. Also, the synergetic effect of the NEB influence and plasma radiation on microorganisms such as Klebsiella is found. © Published under licence by IOP Publishing Ltd.This work was performed within a support of the Russian Science Foundation No. 16-16-04038)

Surface irradiation of chicken eggs by nanosecond electron beam

The irradiation exposure experiments were carried out by means of the pulsed repetitive nanosecond accelerator URT-0.5 (electron energy of up to 500 keV, a pulse width of 50 ns, pulse repetition rate of up to 200pps). The determination of the distribution of the absorbed dose (AD) in the depth in the polyethylene was conducted by a gray wedge. The measurement of the electron beam AD on the surface of the shell (removed from the eggs) and under the shell, as well as beneath the absorber layer (polyethylene 80 microns thick) was also performed by the film dosimeter. Thermoluminescent dosimeters, TLD-500, were used to determine the distribution of the bremsstrahlung AD inside chicken eggs. These results lead to the conclusion that the irradiation of an electron beam with the AD level of 5 kGy is sufficient for complete disinfection on the surface of an egg. The AD inside of it will not exceed 8 cGy because of bremsstrahlung. © RAD Conference Proceedings. All rights reserved

Structural and Magnetic Properties of Nanopowders and Coatings of Carbon-Doped Zinc Oxide Prepared by Pulsed Electron Beam Evaporation

With the help of electron beam evaporation of mechanical mixtures of nonmagnetic micron powders ZnO and carbon in vacuum with the subsequent annealing of evaporation products in air at the temperature of 773 K, single-phase crystal nanopowders ZnO-C were produced with the hexagonal wurtzite structure and low content of the carbon dopant not exceeding 0.25 wt%. It was established that doping ZnO with carbon stimulates primary growth of nanoparticles along the direction 0001 in the coatings. Nanocrystal growth in coatings occurs in the same way as crystal growth in thin films, with growth anisotropy in the c-axis direction in wurtzite ZnO. Element mapping has confirmed homogeneous distribution of carbon in ZnO lattice. Ferromagnetism of single-phase crystal nanopowders ZnO-C with the hexagonal wurtzite structure and low content of the carbon dopant not exceeding 0.25 wt% was produced at room temperature. Ferromagnetic response of the doped NP ZnO-C has exceeded the ferromagnetic response of pure NP ZnO 5 times. The anhysteretic form of magnetization curves NP ZnO-C indicates aspiration of samples to superparamagnetism manifestation

Targeted drug delivery system based on manganese-doped mesoporous silica nanopowder

The purpose of the research was to investigate the potential of using SiO2-MnO2 nanopowder, obtained by electron beam evaporation, as a drug delivery system. The evaluation of the sedimentation stability of suspensions was conducted for further in vivo studies. It was established that PEG stabilized suspensions showed the highest stability. Drug loading and release experiments with nanopowders demonstrated a high drug loading capacity of Amoxicillin and Doxorubicin

Preparation of Silver Coated Oxide Nanomaterials and Study of Their Properties

Nanopowders of aluminum oxide silicon oxide and iron oxide with silver coating were produces by the radiation-chemical method. The dimensions of the nanoparticles were 50 to 80 nm, and the area can be changed from 2-3%, up to 40%. Was carried out the validation of antibacterial properties against E.coli and staphylococcus. Were estimated photocatalytic properties of nanopowders, which showed applications perspective as a photocatalytic agent. Cytotoxic properties were also investigated, which showed the relevance of the use of some the obtained composites for targeted drug delivery. © Journal of Physics: Conference Series 2021.The work was partially supported by the Russian Foundation for Basic Research and the Sverdlovsk Region as part of project No. 20-48-660019

Physical properties of calcium fluoride nanopowder after irradiation by relativistic electrons

Mesoporous CaF2 nanopowders with specific surface area up to 91.5 m2/g have been obtained through evaporation by electron beam in vacuum. The effect of relativistic e-beam irradiation in air on magnetic and texture properties of CaF2 nanoparticles has been studied. The influence of annealing and irradiation on the specific surface area and magnetization of CaF2 nanopowder has been discovered for the first time. © Published under licence by IOP Publishing Ltd.Russian Foundation for Basic Research, RFBR: 18-08-00514This work was performed within the subject of the state task [0389-2015-0026]; was partial supported by the Russian Foundation for Basic Research [18-08-00514]

Production and Investigation of Biological and Photocatalytic Activit Multimodal Nanopowders Produced by Pulsed Electron Beam Evaporation in Vacuum

Nanopowders doped with silver were produced by the methode pulsed electron beam evaporation. © Journal of Physics: Conference Series 2021.The study was carried out with the financial support of RFFI and the Sverdlovsk region as part of the scientific project No. 20-48-660019. For assistance in research, we thank students of the Ural Federal University Troshina Anastasia and Tairov Yevgeny

Physical properties of calcium fluoride nanopowder produced by the method of evaporation by pulsed electron beam in a low-pressure gas

Mesoporous CaF2 nanopowders with the specific surface area up to 88.7 m2/g have been produced by the evaporation by a pulsed electron beam in vacuum. The influence of thermal annealing in air on the size and morphology of CaF2 nanoparticles and their magnetic, luminescence, and texture characteristics has been studied. Ferromagnetism of CaF2 nanopowders was discovered for the first time. The influence of radiation defects (CaF2 dye centers) on magnetic properties of CaF2 nanoparticles has been examined. © Published under licence by IOP Publishing Ltd.Russian Foundation for Basic Research, RFBR: 18-08-00514This work was performed within the subject of the state task [0389-2015-0026]; was partial supported by the Russian Foundation for Basic Research [18-08-00514]