Information Systems Faculty Perceptions of Ethical Work Climate and Job Satisfaction

This study investigated the relationships among egoistic ethical work climate, benevolent ethical work climate, principled ethical work climate, and job satisfaction as perceived by IS faculty at public institutions of higher education in the Southeastern United States. They study relied on constructs from previous studies to measure ethical work climate and job satisfaction. Statistically significant findings were observed between egoistic ethical work climate, benevolent ethical work climate, principled ethical work climate, and job satisfaction. The development of benevolent or principled ethical work climates has a positive relationship with faculty job satisfaction. In contrast, there is a strong inverse correlation between egoistic ethical work climates and faculty’s perception of job satisfaction

Information Systems Faculty Perceptions of Ethical Work Climate and Job Satisfaction

The purpose of this work in progress is to provide an overview of the current research literature in the areas of ethical work climate and employee job satisfaction, and then present a model that will help guide future research on the relationship among egoistic ethical work climate, benevolent ethical work climate, and principled ethical work climate and job satisfaction as perceived by information systems faculty at institutions of higher education in the southeastern United States

Drug dosing during pregnancy—opportunities for physiologically based pharmacokinetic models

Drugs can have harmful effects on the embryo or the fetus at any point during pregnancy. Not all the damaging effects of intrauterine exposure to drugs are obvious at birth, some may only manifest later in life. Thus, drugs should be prescribed in pregnancy only if the expected benefit to the mother is thought to be greater than the risk to the fetus. Dosing of drugs during pregnancy is often empirically determined and based upon evidence from studies of non-pregnant subjects, which may lead to suboptimal dosing, particularly during the third trimester. This review collates examples of drugs with known recommendations for dose adjustment during pregnancy, in addition to providing an example of the potential use of PBPK models in dose adjustment recommendation during pregnancy within the context of drug-drug interactions. For many drugs, such as antidepressants and antiretroviral drugs, dose adjustment has been recommended based on pharmacokinetic studies demonstrating a reduction in drug concentrations. However, there is relatively limited (and sometimes inconsistent) information regarding the clinical impact of these pharmacokinetic changes during pregnancy and the effect of subsequent dose adjustments. Examples of using pregnancy PBPK models to predict feto-maternal drug exposures and their applications to facilitate and guide dose assessment throughout gestation are discussed