427 research outputs found
Theoretical efficiency of the Princeton two-element echelle spectrograph
Echelle spectrometer for use with spaceborne stellar telescope in Advanced Princeton Satellite Stud
Suppression of spin-state transition in epitaxially strained LaCoO_{3}
Epitaxial thin films of LaCoO_{3} (E-LCO) exhibit ferromagnetic order with a
transition temperature T_c = 85 K, while polycrystalline thin LaCoO_{3} films
(P-LCO) remain paramagnetic. The temperature-dependent spin-state structure for
both E-LCO and P-LCO was studied by x-ray absorption spectroscopy at the Co
L_{2,3} and O K edges. Considerable spectral redistributions over temperature
are observed for P-LCO. The spectra for E-LCO, on the other hand, do not show
any significant changes for temperatures between 30 K and 450 K at both edges,
indicating that the spin state remains constant and that the epitaxial strain
inhibits any population of the low-spin (S = 0) state with decreasing
temperature. This observation identifies an important prerequisite for
ferromagnetism in E-LCO thin films.Comment: 5 pages, 5 figures, submitted to Physical Review
Giant Spin Relaxation Anisotropy in Zinc-Blende Heterostructures
Spin relaxation in-plane anisotropy is predicted for heterostructures based
on zinc-blende semiconductors. It is shown that it manifests itself especially
brightly if the two spin relaxation mechanisms (D'yakonov-Perel' and Rashba)
are comparable in efficiency. It is demonstrated that for the quantum well
grown along the [0 0 1] direction, the main axes of spin relaxation rate tensor
are [1 1 0] and [1 -1 0].Comment: 3 pages, NO figure
Spin Orientation and Spin Precession in Inversion-Asymmetric Quasi Two-Dimensional Electron Systems
Inversion asymmetry induced spin splitting of the electron states in quasi
two-dimensional (2D) systems can be attributed to an effective magnetic field B
which varies in magnitude and orientation as a function of the in-plane wave
vector k||. Using a realistic 8x8 Kane model that fully takes into account spin
splitting because of both bulk inversion asymmetry and structure inversion
asymmetry we investigate the spin orientation and the effective field B for
different configurations of a quasi 2D electron system. It is shown that these
quantities depend sensitively on the crystallographic direction in which the
quasi 2D system was grown as well as on the magnitude and orientation of the
in-plane wave vector k||. These results are used to discuss how spin-polarized
electrons can precess in the field B(k||). As a specific example we consider
GaInAs-InP quantum wells.Comment: 10 pages, 6 figure
Effect of bulk inversion asymmetry on the Datta-Das transistor
A model of the Datta-Das spin field-effect transistor is presented which, in
addition to the Rashba interaction, takes into account the influence of bulk
inversion asymmetry of zinc-blende semiconductors. In the presence of bulk
inversion asymmetry, the conductance is found to depend significantly on the
crystallographic orientation of the channel. We determine the channel direction
optimal for the observation of the Datta-Das effect in GaAs and InAs-based
devices.Comment: 4 pages, Revtex4, 4 EPS figure
Magnetotransport in Two-Dimensional Electron Systems with Spin-Orbit Interaction
We present magnetotransport calculations for homogeneous two-dimensional
electron systems including the Rashba spin-orbit interaction, which mixes the
spin-eigenstates and leads to a modified fan-chart with crossing Landau levels.
The quantum mechanical Kubo formula is evaluated by taking into account
spin-conserving scatterers in an extension of the self-consistent Born
approximation that considers the spin degree of freedom. The calculated
conductivity exhibits besides the well-known beating in the Shubnikov-de Haas
(SdH) oscillations a modulation which is due to a suppression of scattering
away from the crossing points of Landau levels and does not show up in the
density of states. This modulation, surviving even at elevated temperatures
when the SdH oscillations are damped out, could serve to identify spin-orbit
coupling in magnetotransport experiments. Our magnetotransport calculations are
extended also to lateral superlattices and predictions are made with respect to
1/B periodic oscillations in dependence on carrier density and strength of the
spin-orbit coupling.Comment: 8 pages including 8 figures; submitted to PR
Physical Examination-Indicated Cerclage
OBJECTIVE:
To estimate the effectiveness of physical examination-indicated cerclage in the setting of second-trimester cervical dilatation by systematic review and meta-analysis of published studies.
DATA SOURCES:
We searched MEDLINE, EMBASE, Scopus, ClinicalTrials.gov, Web of Science, and the Cochrane Library for studies published between 1966 and 2014 that evaluated cervical cerclage for the treatment of cervical insufficiency.
METHODS OF STUDY SELECTION:
The search yielded 6,314 citations. We included cohort studies and randomized controlled trials comparing cerclage placement with expectant management of women with cervical dilatation between 14 and 27 weeks of gestation. Two investigators independently reviewed each citation for inclusion or exclusion and discordant decisions were arbitrated by a third reviewer. Summary estimates were reported as the mean difference and 95% confidence interval (CI) for continuous variables or relative risk and with 95% CI for dichotomous outcomes. Fixed- and random-effects meta-analysis was used, depending on heterogeneity.
TABULATION, INTEGRATION, AND RESULTS:
Ten studies met inclusion criteria and were included in the final analysis. One was a randomized controlled trial, two were prospective cohort studies, and the remaining seven were retrospective cohort studies. Of the 757 women, 485 (64%) underwent physical examination-indicated cerclage placement and 272 (36%) were expectantly managed. Cerclage was associated with increased neonatal survival (71% compared with 43%; relative risk 1.65, 95% CI 1.19-2.28) and prolongation of pregnancy (mean difference 33.98 days, 95% CI 17.88-50.08).
CONCLUSION:
Physical examination-indicated cerclage is associated with a significant increase in neonatal survival and prolongation of pregnancy of approximately 1 month when compared with no such cerclage. The strength of this conclusion is limited by the potential for bias in the included studies
Spin relaxation: From 2D to 1D
In inversion asymmetric semiconductors, spin-orbit interactions give rise to
very effective relaxation mechanisms of the electron spin. Recent work, based
on the dimensionally constrained D'yakonov Perel' mechanism, describes
increasing electron-spin relaxation times for two-dimensional conducting layers
with decreasing channel width. The slow-down of the spin relaxation can be
understood as a precursor of the one-dimensional limit
Mutations in the gene PDE6C encoding the catalytic subunit of the cone photoreceptor phosphodiesterase in patients with achromatopsia
Biallelic PDE6C mutations are a known cause for rod monochromacy, better known as autosomal recessive achromatopsia (ACHM), and earlyâonset cone photoreceptor dysfunction. PDE6C encodes the catalytic αâČâsubunit of the cone photoreceptor phosphodiesterase, thereby constituting an essential part of the phototransduction cascade. Here, we present the results of a study comprising 176 genetically preselected patients who remained unsolved after Sanger sequencing of the most frequent genes accounting for ACHM, and were subsequently screened for exonic and splice site variants in PDE6C applying a targeted next generation sequencing approach. We were able to identify potentially pathogenic biallelic variants in 15 index cases. The mutation spectrum comprises 18 different alleles, 15 of which are novel. Our study significantly contributes to the mutation spectrum of PDE6C and allows for a realistic estimate of the prevalence of PDE6C mutations in ACHM since our entire ACHM cohort comprises 1,074 independent families.In a cohort of 176 genetically undiagnosed achromatopsia patients, we performed screening of the PDE6C gene and identified potentially pathogenic biallelic variants in 15 cases. Taking into account a previous screening approach, we calculate a prevalence of 2.4% for PDE6C mutations in our cohort, which is most probably representative for the Western population. As achromatopsia is in the focus of retinal gene therapy with four clinical trials ongoing, our study provides a valuable resource for putative gene therapy trials targeting PDE6C.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146275/1/humu23606-sup-0001-SuppMat.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146275/2/humu23606_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146275/3/humu23606.pd
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