Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia

The neuropsychological effect of hyperammonemia is variable. This study tests the hypothesis that the effect of ammonia on the neuropsychological function in patients with cirrhosis is determined by the ability of the brain to buffer ammonia-induced increase in glutamine within the astrocyte by losing osmolytes like myo-inositol (mI) and not by the magnitude of the induced hyperammonemia. Fourteen cirrhotic patients with no evidence of overt hepatic encephalopathy were given a 75-g amino acid (aa) solution mimicking the hemoglobin molecule to induce hyperammonemia. Measurement of a battery of neuropsychological function tests including immediate memory, ammonia, aa, and short-echo time proton magnetic resonance spectroscopy were performed before and 4 h after administration of the as solution. Eight patients showed deterioration in the Immediate Memory Test at 4 h. Demographic factors, severity of liver disease, change in plasma ammonia, and as profiles after the as solution were similar in those that showed a deterioration compared with those who did not. In patients who showed deterioration in the memory test, the mI-to-creatine ratio (mI/Cr) was significantly lower at baseline than those that did not deteriorate. In contrast, the glutamate/glutamine-to-Cr ratio was significantly greater in the patients that deteriorated. The observation that deterioration in the memory test scores was greater in those with lower mI/Cr supports the hypothesis that the neuropsychological effects of induced hyperammonemia is determined by the capacity of the brain to handle ammonia-induced increase in glutamine

Fatality rates associated with driving and cycling for all road users in Great Britain 2005–2013

Fatality rates based on deaths only to the drivers themselves do not accurately portray the impact of driving on road traffic deaths. We characterised more fully the impact of driving and cycling on road traffic fatalities by including deaths to all the other road users in fatal car or cycle crashes. We used crash data from the Great Britain National Road Accident Database (STATS19) and exposure data from the National Travel Survey. Rates were estimated as the ratio of fatalities to the amount of time travelled: fatalities per million hours’ use (f/mhu). Rates in 2005-07, 2008-10, and 2011-13 were calculated based on deaths to: (1) the drivers or cyclists themselves (persons ‘in charge’ of vehicles), (2) other, i.e. ‘third-party’, road users (e.g. passengers, drivers or riders of other vehicles, and pedestrians), and (3) both of these groups combined, i.e. all road users. Rates were stratified by the sex and age of the drivers or cyclists involved in the fatal crashes. Rates based on deaths to persons in charge of vehicles were higher for cyclists than for drivers, whereas those based on deaths to third-party road users showed the opposite. The inclusion of third-party deaths increased the overall rates considerably more for drivers than for cyclists. Nevertheless, the overall rate for male cyclists (2011-13: 0.425 f/mhu; 95% Confidence Interval (CI): 0.377–0.478) exceeded that for male drivers (0.257 f/mhu; 95% CI: 0.248–0.267). A similar pattern was observed for females (cycling: 0.216 f/mhu; 95% CI: 0.158–0.287; driving: 0.127 f/mhu; 95% CI: 0.120–0.135). These differences between cars and cycles were overestimated as the safer travel on motorways could not be disaggregated in the estimates for driving. The higher rates for cycling - mainly borne by the cyclists themselves - need to be balanced against the substantially lower risks to other road users

Multifrequency Radio Observations of a SNR in the LMC. The Case of SNR J0527-6549 (DEM l204)

We present a detailed study and results of new Australia Telescope Compact Array (ATCA) observations of supernova remnant, SNR J0527-6549. This Large Magellanic Cloud (LMC) ob ject follows a typical supernova remnant (SNR) horseshoe morphology with a diameter of D=(66x58)+-1 pc which is among the largest SNRs in the LMC. Its relatively large size indicates older age while a steeper than expected radio spectral index of aplha=-0.92+-0.11 is more typical for younger and energetic SNRs. Also, we report detections of regions with a high order of polarization at a peak value of ~54+-17% at 6 cm.Comment: 9 Pages, 6 figures, accepted for publication in SA

Analysing Slavery through Satellite Technology: How Remote Sensing Could Revolutionise Data Collection to Help End Modern Slavery

An estimated 40.3 million people are enslaved globally across a range of industries. Whilst these industries are known, their scale can hinder the fight against slavery. Some industries using slave labour are visible in satellite imagery, including mining, brick kilns, fishing and shrimp farming. Satellite data can provide supplementary details for large scales which cannot be easily gathered on the ground. This paper reviews previous uses of remote sensing in the humanitarian and human rights sectors and demonstrates how Earth Observation as a methodology can be applied to help achieve the United Nations Sustainable Development Goal target 8.7

Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions

Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microbleeds. It causes a quarter of all ischemic strokes, is the commonest cause of vascular dementia, and the cause is incompletely understood. Vascular prophylaxis, as appropriate for large artery disease and cardioembolism, includes antithrombotics, and blood pressure and lipid lowering; however, these strategies may not be effective for small vessel disease, or are already used routinely so precluding further detailed study. Further, intensive antiplatelet therapy is known to be hazardous in small vessel disease through enhanced bleeding. Whether acetylcholinesterase inhibitors, which delay the progression of Alzheimer's dementia, are relevant in small vessel disease remains unclear. Potential prophylactic and treatment strategies might be those that target brain microvascular endothelium and the blood brain barrier, microvascular function and neuroinflammation. Potential interventions include endothelin antagonists, neurotrophins, nitric oxide donors and phosphodiesterase 5 inhibitors, peroxisome proliferator-activated receptor-gamma agonists, and prostacyclin mimics and phosphodiesterase 3 inhibitors. Several drugs that have relevant properties are licensed for other disorders, offering the possibility of drug repurposing. Others are in development. Since influencing multiple targets may be most effective, using multiple agents and/or those that have multiple effects may be preferable. We focus on potential small vessel disease mechanistic targets, summarize drugs that have relevant actions, and review data available from randomized trials on their actions and on the available evidence for their use in lacunar stroke

Early Permian Conodont Fauna and Stratigraphy of the Garden Valley Formation, Eureka County, Nevada

The lower part of the Garden Valley Formation yields two distinct conodont faunas. One of late Asselian age dominated by Mesogondolella and Streptognathodus and one of Artinskian age dominated by Sweetognathus with Mesogondolella. The Asselian fauna contains the same species as those found in the type area of the Asselian in the southern Urals including Mesogondolella dentiseparata, described for the first time outside of the Urals. Apparatuses for Sweetognathus whitei, Diplognathodus stevensi, and Idioprioniodus sp. are described. The Garden Valley Formation represents a marine pro-delta basin and platform, and marine and shore fan delta complex deposition. The fan-delta complex was most likely deposited from late Artinskian to late Wordian. The Garden Valley Formation records tremendous swings in depositional setting from shallow-water to basin to shore