141 research outputs found
Attenuation and damping of electromagnetic fields: Influence of inertia and displacement current
New results for attenuation and damping of electromagnetic fields in rigid
conducting media are derived under the conjugate influence of inertia due to
charge carriers and displacement current. Inertial effects are described by a
relaxation time for the current density in the realm of an extended Ohm's law.
The classical notions of poor and good conductors are rediscussed on the basis
of an effective electric conductivity, depending on both wave frequency and
relaxation time. It is found that the attenuation for good conductors at high
frequencies depends solely on the relaxation time. This means that the
penetration depth saturates to a minimum value at sufficiently high
frequencies. It is also shown that the actions of inertia and displacement
current on damping of magnetic fields are opposite to each other. That could
explain why the classical decay time of magnetic fields scales approximately as
the diffusion time. At very small length scales, the decay time could be given
either by the relaxation time or by a fraction of the diffusion time, depending
whether inertia or displacement current, respectively, would prevail on
magnetic diffusion.Comment: 21 pages, 1 figur
First-Principle Homogenization Theory for Periodic Metamaterials
We derive from first principles an accurate homogenized description of
periodic metamaterials made of magnetodielectric inclusions, highlighting and
overcoming relevant limitations of standard homogenization methods. We obtain
closed-form expressions for the effective constitutive parameters, pointing out
the relevance of inherent spatial dispersion effects, present even in the
long-wavelength limit. Our results clarify the limitations of quasi-static
homogenization models, restore the physical meaning of homogenized metamaterial
parameters and outline the reasons behind magnetoelectric coupling effects that
may arise also in the case of center-symmetric inclusions.Comment: 58 pages, 10 figures Phys. Rev. B, in press (2011
Gauge Theories with Cayley-Klein and Gauge Groups
Gauge theories with the orthogonal Cayley-Klein gauge groups and
are regarded. For nilpotent values of the contraction
parameters these groups are isomorphic to the non-semisimple Euclid,
Newton, Galilei groups and corresponding matter spaces are fiber spaces with
degenerate metrics. It is shown that the contracted gauge field theories
describe the same set of fields and particle mass as gauge
theories, if Lagrangians in the base and in the fibers all are taken into
account. Such theories based on non-semisimple contracted group provide more
simple field interactions as compared with the initial ones.Comment: 14 pages, 5 figure
Theory of Supercoupling, Squeezing Wave Energy, and Field Confinement in Narrow Channels and Tight Bends Using Epsilon-Near-Zero Metamaterials
In this work, we investigate the detailed theory of the supercoupling,
anomalous tunneling effect, and field confinement originally identified in [M.
Silveirinha, N. Engheta, Phys. Rev. Lett. 97, 157403, (2006)], where we
demonstrated the possibility of using materials with permittivity near zero to
drastically improve the transmission of electromagnetic energy through a narrow
irregular channel with very subwavelength transverse cross-section. Here, we
present additional physical insights, describe new applications of the
tunneling effect in relevant waveguide scenarios (e.g., the "perfect" or
"super" waveguide coupling), study the effect of metal losses in the metallic
walls, and the possibility of using epsilon-near zero materials to confine
energy in a subwavelength cavity with gigantic field enhancement. In addition,
we systematically study the propagation of electromagnetic waves through narrow
channels filled with anisotropic epsilon-near zero materials. It is
demonstrated that these materials may have interesting potentials, and that for
some particular geometries the reflectivity of the channel is independent of
the specific dimensions or parameters of epsilon-near zero transition. We also
describe several realistic metamaterial implementations of the studied
problems, based on standard metallic waveguides, microstrip line
configurations, and wire media.Comment: under revie
High frequency diffraction of an electromagnetic plane wave by an imperfectly conducting rectangular cylinder
Copyright @ 2011 IEEEWe shall consider the the problem of determining the scattered far wave field produced when a plane E-polarized wave is incident on an imperfectly conducting rectangular cylinder. By using the the uniform asymptotic solution for the problem of the diffraction of a plane wave by a right-angled impedance wedge, in conjunction with Keller's method, the a high frequency far field solution to the problem is given
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Despite high cure rates in classic Hodgkin lymphoma (cHL), relapses are observed. Whether relapsed cHL represents second primary lymphoma or an underlying T-cell lymphoma (TCL) mimicking cHL is under-investigated. To analyze the nature of cHL recurrences, in-depth clonality testing of immunoglobulin (IG) and T-cell receptor (TR) rearrangements was performed in paired cHL diagnosis and recurrences of 60 patients, supported by targeted mutation analysis of lymphoma-associated genes. Clonal IG rearrangements were detected by next-generation sequencing (NGS) in 69/120 (58%) diagnosis and recurrence samples. The clonal relationship could be established in 34 cases, identifying clonally related relapsed cHL in 24/34 patients (71%). Clonally unrelated cHL was observed in 10/34 patients (29%) as determined by IG-NGS clonality assessment, and confirmed by the identification of predominantly mutually exclusive gene mutations in the paired cHL samples. In recurrences of >2 years, ~60% of cHL patients for which the clonal relationship could be established showed a second primary cHL. Clonal TR gene rearrangements were identified in 14/125 samples (11%), and TCL-associated gene mutations were detected in 7/14 samples. Retrospective pathology review with integration of the molecular findings were consistent with an underlying TCL in 5 patients aged >50 years. This study shows that cHL recurrences, especially after 2 years, sometimes represent a new primary cHL or TCL mimicking cHL, as uncovered by NGS-based IG/TR clonality testing and gene mutation analysis. Given the significant therapeutic consequences, molecular testing of a presumed relapse in cHL is crucial for subsequent appropriate treatment strategies adapted to the specific lymphoma presentation.</p
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Despite high cure rates in classic Hodgkin lymphoma (cHL), relapses are observed. Whether relapsed cHL represents second primary lymphoma or an underlying T-cell lymphoma (TCL) mimicking cHL is under-investigated. To analyze the nature of cHL recurrences, in-depth clonality testing of immunoglobulin (IG) and T-cell receptor (TR) rearrangements was performed in paired cHL diagnosis and recurrences of 60 patients, supported by targeted mutation analysis of lymphoma-associated genes. Clonal IG rearrangements were detected by next-generation sequencing (NGS) in 69/120 (58%) diagnosis and recurrence samples. The clonal relationship could be established in 34 cases, identifying clonally related relapsed cHL in 24/34 patients (71%). Clonally unrelated cHL was observed in 10/34 patients (29%) as determined by IG-NGS clonality assessment, and confirmed by the identification of predominantly mutually exclusive gene mutations in the paired cHL samples. In recurrences of >2 years, ~60% of cHL patients for which the clonal relationship could be established showed a second primary cHL. Clonal TR gene rearrangements were identified in 14/125 samples (11%), and TCL-associated gene mutations were detected in 7/14 samples. Retrospective pathology review with integration of the molecular findings were consistent with an underlying TCL in 5 patients aged >50 years. This study shows that cHL recurrences, especially after 2 years, sometimes represent a new primary cHL or TCL mimicking cHL, as uncovered by NGS-based IG/TR clonality testing and gene mutation analysis. Given the significant therapeutic consequences, molecular testing of a presumed relapse in cHL is crucial for subsequent appropriate treatment strategies adapted to the specific lymphoma presentation.</p
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Despite high cure rates in classic Hodgkin lymphoma (cHL), relapses are observed. Whether relapsed cHL represents second primary lymphoma or an underlying T-cell lymphoma (TCL) mimicking cHL is under-investigated. To analyze the nature of cHL recurrences, in-depth clonality testing of immunoglobulin (IG) and T-cell receptor (TR) rearrangements was performed in paired cHL diagnosis and recurrences of 60 patients, supported by targeted mutation analysis of lymphoma-associated genes. Clonal IG rearrangements were detected by next-generation sequencing (NGS) in 69/120 (58%) diagnosis and recurrence samples. The clonal relationship could be established in 34 cases, identifying clonally related relapsed cHL in 24/34 patients (71%). Clonally unrelated cHL was observed in 10/34 patients (29%) as determined by IG-NGS clonality assessment, and confirmed by the identification of predominantly mutually exclusive gene mutations in the paired cHL samples. In recurrences of >2 years, ~60% of cHL patients for which the clonal relationship could be established showed a second primary cHL. Clonal TR gene rearrangements were identified in 14/125 samples (11%), and TCL-associated gene mutations were detected in 7/14 samples. Retrospective pathology review with integration of the molecular findings were consistent with an underlying TCL in 5 patients aged >50 years. This study shows that cHL recurrences, especially after 2 years, sometimes represent a new primary cHL or TCL mimicking cHL, as uncovered by NGS-based IG/TR clonality testing and gene mutation analysis. Given the significant therapeutic consequences, molecular testing of a presumed relapse in cHL is crucial for subsequent appropriate treatment strategies adapted to the specific lymphoma presentation.</p
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Despite high cure rates in classic Hodgkin lymphoma (cHL), relapses are observed. Whether relapsed cHL represents second primary lymphoma or an underlying T-cell lymphoma (TCL) mimicking cHL is under-investigated. To analyze the nature of cHL recurrences, in-depth clonality testing of immunoglobulin (IG) and T-cell receptor (TR) rearrangements was performed in paired cHL diagnosis and recurrences of 60 patients, supported by targeted mutation analysis of lymphoma-associated genes. Clonal IG rearrangements were detected by next-generation sequencing (NGS) in 69/120 (58%) diagnosis and recurrence samples. The clonal relationship could be established in 34 cases, identifying clonally related relapsed cHL in 24/34 patients (71%). Clonally unrelated cHL was observed in 10/34 patients (29%) as determined by IG-NGS clonality assessment, and confirmed by the identification of predominantly mutually exclusive gene mutations in the paired cHL samples. In recurrences of >2 years, ~60% of cHL patients for which the clonal relationship could be established showed a second primary cHL. Clonal TR gene rearrangements were identified in 14/125 samples (11%), and TCL-associated gene mutations were detected in 7/14 samples. Retrospective pathology review with integration of the molecular findings were consistent with an underlying TCL in 5 patients aged >50 years. This study shows that cHL recurrences, especially after 2 years, sometimes represent a new primary cHL or TCL mimicking cHL, as uncovered by NGS-based IG/TR clonality testing and gene mutation analysis. Given the significant therapeutic consequences, molecular testing of a presumed relapse in cHL is crucial for subsequent appropriate treatment strategies adapted to the specific lymphoma presentation.</p
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