viDA Thereapeutics, Inc. Business Plan

viDA Therapeutics Inc. (herein called viDA), with headquarters in Vancouver, British Columbia, was incorporated in April of 2008. viDA is a new specialty biotechnology company focused on the discovery, development and commercialization of first-in-class drugs for the treatment of age-related degenerative processes, such as age related wrinkling and hair loss. viDA has chosen a distinct company strategy, focusing strongly on the development and marketing of specialty products. viDA bases its business model in the remarkable and patented discoveries surrounding granzymes. Granzymes have been shown to play a central and pivotal role in the destruction of proteins vital in one’s body anti-aging processes that prevent skin wrinkling and hair loss. viDA is currently looking to secure an initial round of funding of $1.5 million for 2008 and an additional$6 million for 2009 to perform further target identification, target validation, preclinical research and early-stage clinical development. We recommend that viDA seeks the full $7.5 million in Series A an Series B financing simultaneously to ensure adequate funds to meet projected milestones

Pelaksanaan Pungutan Pajak Bahan Galian Golongan C dalam Menunjang Pendapatan Asli Daerah Kabupaten Solok Selatan

Alongwiththeregionalautonomy, lcal government areexpected to be able manage andmaximize eisting resources in theregins for the continuity of theprogress of itself. One of thegovernment s efforts to increaserevenue kabupaten solok selatanoriginal the area is through thetax excavation category c Ingeneral. the contribution of thetax excavation golongan c thelocal revenue of Kabupaten SolokSelatan, Still relatively small , butsignificant enough in financingadministering government ofKabupaten Solok SelatanKata Kunci : Tax excavacation, paja

HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

Hepatitis C virus (HCV) infection is a leading cause of liver fibrosis, especially in developing countries. The process is characterized by the excess accumulation of ECM that may lead, over time, to hepatic cirrhosis, liver failure and also to hepatocarcinoma. The direct role of HCV in promoting fibroblasts trans-differentiation into myofibroblasts, the major fibrogenic cells, has not been fully clarified. In this study, we found that HCV derived from HCV-infected patients infected and directly induced the trans-differentiation of human primary fibroblasts into myofibroblasts, promoting fibrogenesis. This effect correlated with the activation of GLI2, one of the targets of Hedgehog signaling pathway previously reported to be involved in myofibroblast generation. Moreover, GLI2 activation by HCV correlated with a reduction of autophagy in fibroblasts, that may further promoted fibrosis. GLI2 inhibition by Gant 61 counteracted the pro-fibrotic effects and autophagy inhibition mediated by HCV, suggesting that targeting HH/GLI2 pathway might represent a promising strategy to reduce the HCV-induced fibrosis

Modified mattress sutures vs running sutures in uterine closure: which is better?

Background: Conventional closure of uterus has been known to bear risk of scar dehiscence and scar rupture in subsequent pregnancies and thus, a study was conducted to compare the outcome of uterine closure with modified mattress manner and running manner and to establish a better method of uterine closure during caesarean section. Objective was to compare the conventional single layer running sutures and single layer modified mattress sutures for closure of uterus in caesarean section and find out which method is superior.Methods: This prospective interventional study was carried out in Dhiraj Hospital, a tertiary care hospital in Vadodara. 60 pregnant women in the study criteria were equally divided randomly into 2 groups. Uterine closure was done in single layered sutures, one by running sutures and other group by modified mattress sutures.Results: Uterine scar thickness on 8th day and 6 months post-operatively was significantly more in single layered suturing by modified mattress suture compared to running suture (p <0.05).Conclusions: Uterine closure by single layered modified mattress suture is better in comparison to conventional single layer running suture

H++: a server for estimating pK(a)s and adding missing hydrogens to macromolecules

The structure and function of macromolecules depend critically on the ionization (protonation) states of their acidic and basic groups. A number of existing practical methods predict protonation equilibrium pK constants of macromolecules based upon their atomic resolution Protein Data Bank (PDB) structures; the calculations are often performed within the framework of the continuum electrostatics model. Unfortunately, these methodologies are complex, involve multiple steps and require considerable investment of effort. Our web server provides access to a tool that automates this process, allowing both experts and novices to quickly obtain estimates of pKs as well as other related characteristics of biomolecules such as isoelectric points, titration curves and energies of protonation microstates. Protons are added to the input structure according to the calculated ionization states of its titratable groups at the user-specified pH; the output is in the PQR (PDB + charges + radii) format. In addition, corresponding coordinate and topology files are generated in the format supported by the molecular modeling package AMBER. The server is intended for a broad community of biochemists, molecular modelers, structural biologists and drug designers; it can also be used as an educational tool in biochemistry courses

Seven Steps Towards the Classical World

Classical physics is about real objects, like apples falling from trees, whose motion is governed by Newtonian laws. In standard Quantum Mechanics only the wave function or the results of measurements exist, and to answer the question of how the classical world can be part of the quantum world is a rather formidable task. However, this is not the case for Bohmian mechanics, which, like classical mechanics, is a theory about real objects. In Bohmian terms, the problem of the classical limit becomes very simple: when do the Bohmian trajectories look Newtonian?Comment: 16 pages, LaTeX, uses latexsy

Macroscopic coherence of a single exciton state in a polydiacetylene organic quantum wire

We show that a single exciton state in an individual ordered conjugated polymer chain exhibits macroscopic quantum spatial coherence reaching tens of microns, limited by the chain length. The spatial coherence of the k=0 exciton state is demonstrated by selecting two spatially separated emitting regions of the chain and observing their interference.Comment: 12 pages with 2 figure

Stark Spectroscopy and Radiative Lifetimes in Single Self-Assembled CdTe Quantum Dots

We present studies on Coulomb interactions in single self-assembled CdTe quantum dots. We use a field effect structure to tune the charge state of the dot and investigate the impact of the charge state on carrier wave functions. The analysis of the quantum confined Stark shifts of four excitonic complexes allows us to conclude that the hole wave function is softer than electron wave function, i. e. it is subject to stronger modifications upon changing of the dot charge state. These conclusions are corroborated by time-resolved photoluminescence studies of recombination lifetimes of different excitonic complexes. We find that the lifetimes are notably shorter than expected for strong confinement and result from a relatively shallow potential in the valence band. This weak confinement facilitates strong hole wave function redistributions. We analyze spectroscopic shifts of the observed excitonic complexes and find the same sequence of transitions for all studied dots. We conclude that the universality of spectroscopic shifts is due to the role of Coulomb correlations stemming from strong configuration mixing in the valence band.Comment: sent to Physical Review

On a Symmetry Argument for the Guidance Equation in Bohmian Mechanics

Bohmian mechanics faces an underdetermination problem: when it comes to solving the measurement problem, alternatives to the Bohmian guidance equation work just as well as the official guidance equation. Dürr, Goldstein, and Zanghì have argued that of the candidate guidance equations, the official guidance equation is the simplest Galilean‐invariant candidate. This symmetry argument—if it worked—would solve the underdetermination problem. But the argument does not work. It fails because it rests on assumptions about how Galilean transformations (especially boosts) act on the wavefunction that are (in this context) unwarranted. My discussion has larger morals about the physical significance of certain mathematical results (like, for example, Wigner’s theorem) in non‐orthodox interpretations of quantum mechanics