Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes

Anti-Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens