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A Poli

AA Beg

AJ García-Piñeres

AK Picman

AM Helal

B Siedle

BH Kwok

C Cavin

C Zidorn

CA Dinarello

CC Lin

CC Tsai

DA Valério

EJ Kim

EK Barbour

Fadia R Homaidan

FR Homaidan

G Lyss

GR Schinella

H Ichikawa

H Schröder

HZ Jin

IH Hall

J Morton

JA DiDonato

Jamal Al-Saghir

K Medjroubi

KA Barada

M Bruno

MC Recio

MG Neuman

MJ Abad

Najat A Saliba

P Kapahi

P Rüngeler

PA Baeuerle

PE Auron

PJ Barnes

PM Bork

R Al-Ashy

Rabih S Talhouk

Ralph Salloum

Randa Al-Ashi

S Tornhamre

SM Kupchan

SP Hehner

TD Gilmore

TJ Schmidt

U Aslan

V Castro

V Vajs

VH Heywood

English

PubMed

Springer - Publisher Connector

Anti-Inflammatory properties of Salograviolide A purified from Lebanese plant 


Anti-Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis

Abstract
Background
Anti-inflammatory activities of medicinal plants have largely been attributed to their content of sesquiterpene lactones (SLs). SLs are predominantly found in the sunflower family Asteraceae and have been isolated from many plants of this family, particularly Centaurea. The anti-inflammatory activities of extract of Centaurea ainetensis, a Lebanese endemic plant, and the isolated active molecule were assessed for their potential ant-inflammatory activities.
Methods
Plant extract from Centaurea ainetensis, and the isolated active ingredient Salograviolide A (SA), a sesquiterpene lactones guaianolide, were used for the study. Western blotting and electrophoretic mobility shift assays were used to test the effects of the plant extract and SA on interleukin-1 (IL-1) induced increase in cyclooxygenase-2 (COX-2) levels and in nuclear factor-κB (NF-κB) translocation in an intestinal epithelial cell (IEC) of inflammation. Their effects on inflammation score and cytokine levels were also studied in an iodoacetoamide-induced rat model of inflammation.
Results
Plant extract and SA were shown to reverse the effects observed by IL-1 on COX-2 levels and NF-κB translocation in IEC. SA decreased the level of inflammatory cytokines and the level of inflammation in the animal model.
Conclusion
These findings suggest that SA may be useful in the development of natural therapies for inflammatory diseases

Al-Saghir, Jamal

Al-Ashi, Randa

Salloum, Ralph

Saliba, Najat A

Talhouk, Rabih S

Homaidan, Fadia R

Digital Commons@Wayne State University

Crossref

Abstract Background Anti-inflammatory activities of medicinal plants have largely been attributed to their content of sesquiterpene lactones (SLs). SLs are predominantly found in the sunflower family Asteraceae and have been isolated from many plants of this family, particularly Centaurea. The anti-inflammatory activities of extract of Centaurea ainetensis, a Lebanese endemic plant, and the isolated active molecule were assessed for their potential ant-inflammatory activities. Methods Plant extract from Centaurea ainetensis, and the isolated active ingredient Salograviolide A (SA), a sesquiterpene lactones guaianolide, were used for the study. Western blotting and electrophoretic mobility shift assays were used to test the effects of the plant extract and SA on interleukin-1 (IL-1) induced increase in cyclooxygenase-2 (COX-2) levels and in nuclear factor-κB (NF-κB) translocation in an intestinal epithelial cell (IEC) of inflammation. Their effects on inflammation score and cytokine levels were also studied in an iodoacetoamide-induced rat model of inflammation. Results Plant extract and SA were shown to reverse the effects observed by IL-1 on COX-2 levels and NF-κB translocation in IEC. SA decreased the level of inflammatory cytokines and the level of inflammation in the animal model. Conclusion These findings suggest that SA may be useful in the development of natural therapies for inflammatory diseases.</p

Saliba Najat A

Salloum Ralph

Al-Ashi Randa

Al-Saghir Jamal

Talhouk Rabih S

Homaidan Fadia R

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Anti-Inflammatory properties of Salograviolide A purified from Lebanese plant <it>Centaurea ainetensis</it>

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Anti-Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis

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