3,486 research outputs found

    Fluid mechanics approach to acoustic liner design

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    Fluid mechanics approach to acoustic liner desig

    SBV regularity for Hamilton-Jacobi equations with Hamiltonian depending on (t,x)

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    In this paper we prove the special bounded variation regularity of the gradient of a viscosity solution of the Hamilton-Jacobi equation partial derivative(t)u + H(t, x, D(x)u) = 0 in Omega subset of [0, T] x R-n under the hypothesis of uniform convexity of the Hamiltonian H in the last variable. This result extends the result of Bianchini, De Lellis, and Robyr obtained for a Hamiltonian H = H(D(x)u) which depends only on the spatial gradient of the solution

    SBV-like regularity for Hamilton-Jacobi equations with a convex Hamiltonian

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    In this paper we consider a viscosity solution u of the Hamilton-Jacobi equation partial derivative(t)u + H(D(x)u) = 0 in Omega subset of [0,T] x R-n. where H is smooth and convex. We prove that when d(t,center dot) := H-p(D(x)u(t,center dot)), H-p := del H is BV for all t epsilon [0, T] and suitable hypotheses on the Lagrangian L hold, the Radon measure divd(t,center dot) can have Cantor part only for a countable number of t's in [0,T]. This result extends a result of Robyr for genuinely nonlinear scalar balance laws and a result of Bianchini, De Lellis and Robyr for uniformly convex Hamiltonians

    TFM-Explorer: mining cis-regulatory regions in genomes

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    DNA-binding transcription factors (TFs) play a central role in transcription regulation, and computational approaches that help in elucidating complex mechanisms governing this basic biological process are of great use. In this perspective, we present the TFM-Explorer web server that is a toolbox to identify putative TF binding sites within a set of upstream regulatory sequences of genes sharing some regulatory mechanisms. TFM-Explorer finds local regions showing overrepresentation of binding sites. Accepted organisms are human, mouse, rat, chicken and drosophila. The server employs a number of features to help users to analyze their data: visualization of selected binding sites on genomic sequences, and selection of cis-regulatory modules. TFM-Explorer is available at http://bioinfo.lifl.fr/TFM

    Non-Pharmacological Treatments in Lewy Body Disease: A Systematic Review

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    Introduction: Lewy body disease (LBD) is the second most common neurodegenerative disorder in patients older than 65 years. LBD is characterized by heterogeneous symptoms like fluctuation in attention, visual hallucinations, Parkinsonism, and REM sleep behaviour disorders. Considering the relevant social impact of the disease, identifying effective non-pharmacological treatments is becoming a priority. The aim of this systematic review was to provide an up-to-date literature review of the most effective non-pharmacological treatments in patients with LBD, focussing on evidence-based interventions. Methods: Following PRISMA criteria, we carried out a systematic search through three databases (PubMed, Cochrane Libraries, and PEDro) including physical therapy (PT), cognitive rehabilitation (CR), light therapy (LT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), deep brain stimulation (DBS). All studies were qualitatively assessed using standardized tools (CARE and EPHPP). Results: We obtained a total of 1,220 studies of which 23 original articles met eligibility criteria for inclusion. The total number of LBD patients included was 231; mean age was 69.98, predominantly men (68%). Some PT studies highlighted improvements in motor deficits. CR produced significant improvements in mood, cognition, and patient's quality of life and satisfaction. LT outlined a partial trend of improvements in mood and sleep quality. DBS, ECT, and TMS showed some partial improvements mainly on neuropsychiatric symptoms, whereas tDCS provided partial improvements in attention. Conclusion: This review highlights the efficacy of some evidence-based rehabilitation studies in LBD; however, further randomized controlled trials with larger samples are needed to provide definitive recommendations
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